08328nam 2202713z- 450 991055740460332120231214133716.0(CKB)5400000000043630(oapen)https://directory.doabooks.org/handle/20.500.12854/69315(EXLCZ)99540000000004363020202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Tight Junction and Its ProteinsMore Than Just a BarrierBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (432 p.)3-03943-300-8 3-03943-301-6 For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.Tight Junction and Its Proteins Medicinebicssctissue barriertight junctionclaudinstricellulintight junctionsorgan preservationintestinetransplantationischemiaintestinal mucosalungepitheliainterleukin 13UBE2Zubiquitinosmolalityhydrostatic pressurecancersensortricellular tight junctionsendometrial cancerepithelial barrier dysfunctionClaudin-7permeabilityWNK4epithelial sodium channel (ENaC), collecting duct cellsclaudin-1hydrogen peroxidephosphorylationclaudinangulindrug developmentangubindin-1Clostridium perfringens enterotoxinClostridium perfringens iota-toxinantibodyMz-ChA-1 cellsbiliary epithelial cellsphosphatidylcholinemucusparacellular transportatopic dermatitiscytokinesSTAT3ZO-2cholestasisgene transcriptionhypertrophytumor suppressorNLSNESCaSRRhoAbarrier functionparacellular permeabilityantidiuretic hormoneClaudin-14CLDN14hearing lossvestibular functioncochlear implantationHepatitis C Virusviral entryepidermal barrierreconstructed human epidermisclaudin targetingCampylobacter jejunicurcuminapoptosisco-culturemouse colonTNFNFκBlipolysis-stimulated lipoprotein receptor (LSR)epithelial barriercell–cell contactcaspasekidney stonesion reabsorptionquercetinbrain barriersblood-brain barrierneurovascular unitblood-cerebrospinal fluid barrierarachnoid barrierglia limitansadherens junctionsparacellular sodium transportthick ascending limbnephropathyHELIX syndromehypokalemiahypermagnesemiaanhidrosisgland dysfunctionagingblood–brain barriermutationskidneyliverskinhumanmicediseasein silicodrug discoverymembrane proteinsprotein interactionsmolecular dynamicsantibiotic-associated hemorrhagic colitisKlebsiella oxytocatight junction assemblymonocytesceliac diseaseclaudin-2epitheliuminflammationfibrosisproliferationmigrationtricellular tight junctionparacellular water transporttight epitheliumMDCK C7 cellscell growthendotheliaadherens junctionapical junctional complexAMP-activated protein kinase (AMPK)paracellular barrierprotein structureprotein domainoccludinjunctional adhesion moleculezonula occludensMAGUK proteinsPDZ domainstem cellchemoresistanceretinal pigment epitheliumretinopathybarrier formationcollecting ductclaudin-5neuropathic painnerve injurydorsal root ganglionenteropathogenic E. coli (EPEC)tight junctions (TJ)polarityatypical aPKCζtransepithelial electrical resistance (TER)sorting nexin 9 (SNX9)EspFclaudin 1tumormetastasisepithelial to mesenchymal transitioncerebral cavernous malformationendothelial barrierRhoROCKMEKK3ion transportion channelsuper-resolution microscopystructured illumination microscopystimulated emission depletionsingle molecule localization microscopyClaudinblood-biliary barrierchronic liver diseasehepatocellular carcinomacholangiocellular carcinomaNISCH syndromerepairNHE2ClC-2inflammatory bowel diseasemucosal immunologyZO-1actomyosinaquaporindrinking rateepithelial fluid transportenterocyteosmoregulationparacellularproximal tubulecalcium permeabilityclaudin-12paracellular channels and barrierscell polaritypathogensimmune cellsenvironmental sensorsMedicineFromm Michaeledt1287935Krug Susanne MedtFromm MichaelothKrug Susanne MothBOOK9910557404603321The Tight Junction and Its Proteins3020581UNINA