03754nam 2200985z- 450 991055738040332120220111(CKB)5400000000042095(oapen)https://directory.doabooks.org/handle/20.500.12854/76432(oapen)doab76432(EXLCZ)99540000000004209520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierImmunohistochemical ExpressionBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (168 p.)3-0365-0400-1 3-0365-0401-X Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists' practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the visualization of an antibody-antigene binding complex under a light microscope [1]. Coon et al., in 1941 [2], first introduced the use of fluorochrome-conjugated antibodies in clinical practice. Since then, IHC has gone from being a useful tool for identifying the differentiation line of otherwise undifferentiated cells to a technique capable of providing not only diagnostic but also prognostic and predictive indications of responses to specific therapeutic options [1,3]. The abovementioned peculiarities have made IHC one of the most used ancillary methods in the histopathological approach to human neoplastic and non-neoplastic diseases [3-5]. This Special Issue contains 11 accepted papers that provide readers with a comprehensive update on current and future applications of IHC in medical practice.MedicinebicsscABCB5c-kitcarcinogenesischaperonopathiescytokeratinDENdifferential diagnosisEGCGenteric nervous systemexcretion fraction of uric acidfollicular adenomafollicular carcinomaheartHsp27Hsp60Hsp70Hsp90human embryonal/fetal tissueshypouricemiaimmunohistochemistryinflammationinitial lymphaticskidneylivermacroH2Amatrix metalloproteinasesmegacystismetastasismolecular chaperonen/aneoplastic tissueNGALoutcome and prognosisoxidative stressPDGFRpericardiumprognosisprognostic factorprostate cancerSLC22A12temporomandibular jointtemporomandibular joint disorderthyroidtraining exerciseultra-structural changesURAT1uric acid transportersurinary tract malformationsuveal melanomaVDRVitamin DWT1MedicineCaltabiano Rosarioedt1314843Loreto CarlaedtCaltabiano RosarioothLoreto CarlaothBOOK9910557380403321Immunohistochemical Expression3032037UNINA