04894nam 2201081z- 450 991055737110332120231214132937.0(CKB)5400000000042180(oapen)https://directory.doabooks.org/handle/20.500.12854/76965(EXLCZ)99540000000004218020202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Conformational Universe of Proteins and Peptides: Tales of Order and DisorderBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (230 p.)3-0365-2352-9 3-0365-2351-0 Proteins represent one of the most abundant classes of biological macromolecules and play crucial roles in a vast array of physiological and pathological processes. The knowledge of the 3D structure of a protein, as well as the possible conformational transitions occurring upon interaction with diverse ligands, are essential to fully comprehend its biological function.In addition to globular, well-folded proteins, over the past few years, intrinsically disordered proteins (IDPs) have received a lot of attention. IDPs are usually aggregation-prone and may form toxic amyloid fibers and oligomers associated with several human pathologies. Peptides are smaller in size than proteins but similarly represent key elements of cells. A few peptides are able to work as tumor markers and find applications in the diagnostic and therapeutic fields. The conformational analysis of bioactive peptides is important to design novel potential drugs acting as selective modulators of specific receptors or enzymes. Nevertheless, synthetic peptides reproducing different protein fragments have frequently been implemented as model systems in folding studies relying on structural investigations in water and/or other environments.This book contains contributions (seven original research articles and five reviews published in the journal Molecules) on the above-described topics and, in detail, it includes structural studies on globular folded proteins, IDPs and bioactive peptides. These works were conducted usingdifferent experimental methods.Conformational Universe of Proteins and PeptidesResearch & information: generalbicsscmass spectrometric epitope mappinggas phase immune complex dissociationapparent gas phase dissociation constantsapparent gas phase activation energiesITEM-TWOnative mass spectrometryTRIOBPcancerdeafnesshearing lossmental illnessschizophreniaactincytoskeletondisordered structureprotein aggregationsolid-state NMRELDOR-detected NMRATP hydrolysisATP analoguesDnaB helicaseABC transporterbiopesticidesantifungal activityinsecticidal activitymechanism of actiontransgenic cropsprotein foldingNMRHigh Hydrostatic PressureACE2viral spike receptor-binding domainSARS-CoV-2transmissionbioinformaticsIDP 1binding 2molecular dynamics 3MELD×MD 4advanced sampling 5p53 6MDM2 7NAD(P)H-dependent oxidoreductasezinc-containing alcohol dehydrogenasecofactor binding and releaseinterdomain cleft dynamicsmolecular dynamics simulationsdenatured state ensembleprotein coil librarypeptidesintrinsically disordered proteinsion-pairing interactionside-chain lengthcharged amino acidsβ-hairpinpeptideFriedman's testbackbone atom coordinate variances and uncertaintiessuperimpositionnanobodyprotein structureimmunoglobulin domainResearch & information: generalLeone Marilisaedt1307052Leone MarilisaothBOOK9910557371103321The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder3028659UNINA