05554nam 2201369z- 450 991055737030332120231214133212.0(CKB)5400000000042188(oapen)https://directory.doabooks.org/handle/20.500.12854/77079(EXLCZ)99540000000004218820202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAnticancer Properties of Natural and Derivative ProductsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (312 p.)3-0365-2588-2 3-0365-2589-0 Natural products are bioactive compounds synthesized by terrestrial and marine plants, microorganisms and animals, whose main objective is to prevent them from attacks by predators and/or pathogens. Traditionally since ancient times, different cultures have used these compounds for the prevention and treatment of various human diseases. During the last few years, it has been reported that most of these phytochemicals possess a variety of interesting and significant biological properties, such as analgesic, antiallodynic, antidiabetic, antioxidant, antiparasitic, antimicrobial, antiviral, antiatherogenic, anti-inflammatory, antiproliferative, antitumor and normal growth stimulants, as well as significant cardioprotective and neuroprotective activity. This thematic book aims to collect and disseminate some of the most significant and recent contributions of the use of the natural compounds called phytochemicals, as well as some of their chemical derivatives, for the prevention and treatment of cancer and other accompanying diseases. On the other hand, in recent years, the synthesis of numerous chemical derivatives of these natural compounds has also intensified, with the aim of enhancing their bioactive capacities. Among all these bioactivities, special attention has been paid to its antitumor capacity through the potential modulation of cancer initiation and growth, cell differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. In addition, a considerable number of studies have linked their anticancer effects to their anti-inflammatory and antioxidant activities.Research & information: generalbicssctotal phenolic contenttotal flavonoid contentGC-MSDPPHantioxidantanticancer agentanti-inflammatory agentgingival fibroblastsoral cancernatural extractAdenosma bracteosumextractanti-cancercell lineisolated compoundscaspase-3bioactive compoundsmetaboliteswinegrapesbreast cancerchemopreventionchemotherapysquamous cell carcinomaMoringa oleifera3-hydroxy-β-iononeantioxidant activityantioxidant enzymesanti-proliferative activitymaslinic acidmelanomaOlea europaea L.ROS levelsphotodynamic therapycancerphotosensitisernatural compoundsElaeagnus angustifoliaEMTapoptosisAKT/PI3K signaling pathwayhuman hepatocarcinoma HepG2 cellsmigration activityproliferationoxidative stressROS leveluvaollung metastasesin vivocomplementary medicinemedicinal mushroomstriterpenoic acidtormentic acidbetulinic acidoleanolic acidrhodamine Bcytotoxicityhepatocellular carcinoma (HCC)Pogostemon cablin (PPa extract)cell cyclesynergismnatural photosensitive compoundsanticancer activityhypericinemodinquinizarindanthroninteractionDNAglioblastoma (GBM)lactucopicrin (LCTP)temozolomide (TMZ)autophagyNF-κBp62/SQSM1natural producttherapeutic triglyceridexenograft studyCaveolin-1actin cytoskeletonbetulin glycoconjugatesclick chemistry1,3-dipolar cycloadditionResearch & information: generalLupiáñez José Antonioedt1328632Pérez-Jiménez AmaliaedtRufino-Palomares Eva EedtLupiáñez José AntonioothPérez-Jiménez AmaliaothRufino-Palomares Eva EothBOOK9910557370303321Anticancer Properties of Natural and Derivative Products3038752UNINA