05595nam 2201393z- 450 991055737030332120220111(CKB)5400000000042188(oapen)https://directory.doabooks.org/handle/20.500.12854/77079(oapen)doab77079(EXLCZ)99540000000004218820202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAnticancer Properties of Natural and Derivative ProductsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (312 p.)3-0365-2588-2 3-0365-2589-0 Natural products are bioactive compounds synthesized by terrestrial and marine plants, microorganisms and animals, whose main objective is to prevent them from attacks by predators and/or pathogens. Traditionally since ancient times, different cultures have used these compounds for the prevention and treatment of various human diseases. During the last few years, it has been reported that most of these phytochemicals possess a variety of interesting and significant biological properties, such as analgesic, antiallodynic, antidiabetic, antioxidant, antiparasitic, antimicrobial, antiviral, antiatherogenic, anti-inflammatory, antiproliferative, antitumor and normal growth stimulants, as well as significant cardioprotective and neuroprotective activity. This thematic book aims to collect and disseminate some of the most significant and recent contributions of the use of the natural compounds called phytochemicals, as well as some of their chemical derivatives, for the prevention and treatment of cancer and other accompanying diseases. On the other hand, in recent years, the synthesis of numerous chemical derivatives of these natural compounds has also intensified, with the aim of enhancing their bioactive capacities. Among all these bioactivities, special attention has been paid to its antitumor capacity through the potential modulation of cancer initiation and growth, cell differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. In addition, a considerable number of studies have linked their anticancer effects to their anti-inflammatory and antioxidant activities.Research and information: generalbicssc1,3-dipolar cycloaddition3-hydroxy-β-iononeactin cytoskeletonAdenosma bracteosumAKT/PI3K signaling pathwayanti-canceranti-inflammatory agentanti-proliferative activityanticancer activityanticancer agentantioxidantantioxidant activityantioxidant enzymesapoptosisautophagybetulin glycoconjugatesbetulinic acidbioactive compoundsbreast cancercancercaspase-3Caveolin-1cell cyclecell linechemopreventionchemotherapyclick chemistrycomplementary medicinecytotoxicitydanthronDNADPPHElaeagnus angustifoliaemodinEMTextractGC-MSgingival fibroblastsglioblastoma (GBM)grapeshepatocellular carcinoma (HCC)human hepatocarcinoma HepG2 cellshypericinin vivointeractionisolated compoundslactucopicrin (LCTP)lung metastasesmaslinic acidmedicinal mushroomsmelanomametabolitesmigration activityMoringa oleiferan/anatural compoundsnatural extractnatural photosensitive compoundsnatural productNF-κBOlea europaea L.oleanolic acidoral canceroxidative stressp62/SQSM1photodynamic therapyphotosensitiserPogostemon cablin (PPa extract)proliferationquinizarinrhodamine BROS levelROS levelssquamous cell carcinomasynergismtemozolomide (TMZ)therapeutic triglyceridetormentic acidtotal flavonoid contenttotal phenolic contenttriterpenoic aciduvaolwinexenograft studyResearch and information: generalLupiáñez José Antonioedt1328632Pérez-Jiménez AmaliaedtRufino-Palomares Eva EedtLupiáñez José AntonioothPérez-Jiménez AmaliaothRufino-Palomares Eva EothBOOK9910557370303321Anticancer Properties of Natural and Derivative Products3038752UNINA