04708nam 2201321z- 450 991055735640332120220111(CKB)5400000000042325(oapen)https://directory.doabooks.org/handle/20.500.12854/76311(oapen)doab76311(EXLCZ)99540000000004232520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierUbiquitination in Health and DiseasesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (292 p.)3-0365-0546-6 3-0365-0547-4 Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled "Ubiquitination in Health and Disease" successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.HumanitiesbicsscSocial interactionbicsscaggregationaldosterone sensitive distal nephronblood pressurecancerciliaciliogenesisciliopathycortical bone derived stem celldegradationdeubiquitinasedeubiquitinasesdeubiquitinationdifferentiationdisulfide-couplingdopa-responsive dystoniaDUBsE3 ubiquitin ligaseE3sendoplasmic reticulum stressepithelial sodium channelexcitation-transcription couplingfatty acid-binding protein 3fibrilsgenetic diseaseshematopoiesishematopoietic stem cellsimmune responseimmune-related diseasesinflammationinhibitorinhibitorsinnate immuneinterferonLUBACmesenchymal stem cellmitochondriaMITOL/MARCH5monoubiquitin signalingmTORmyocardial infarctionNedd4L/Nedd4-2neurodegenerationneurodegenerative diseaseNF-κBosmotic stressParkinson's diseasepolyubiquitinproliferationproteasomal degradationprotein complex formationprotein quality controlprotein stabilizationproteolysisregulation of gene expressionregulatory T cellsrenal salt reabsorptionRING fingerRNF152RNF182RNF183RNF186salt-sensitive hypertensionsemisynthesistau proteintherapeutic targettyrosine hydroxylaseubiquitinubiquitin codeubiquitin ligaseubiquitin proteasome systemubiquitin systemubiquitin-proteasome pathwayubiquitin-proteasome systemubiquitinationUPSvascular functionvesicular traffickingvirus infectionvirus-host interactionα-synucleinHumanitiesSocial interactionIshigami Tomoakiedt1303374Ishigami TomoakiothBOOK9910557356403321Ubiquitination in Health and Diseases3026962UNINA