04699nam 2201309z- 450 991055735640332120231214133602.0(CKB)5400000000042325(oapen)https://directory.doabooks.org/handle/20.500.12854/76311(EXLCZ)99540000000004232520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierUbiquitination in Health and DiseasesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (292 p.)3-0365-0546-6 3-0365-0547-4 Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.HumanitiesbicsscSocial interactionbicsscdeubiquitinasedegradationtherapeutic targetcancerhematopoiesishematopoietic stem cellsimmune responseregulation of gene expressionubiquitin systemgenetic diseasesubiquitin ligasedeubiquitinasesmonoubiquitin signalingvesicular traffickingprotein complex formationinflammationinhibitorinnate immuneinterferonLUBACNF-κBubiquitinParkinson’s diseasedopa-responsive dystoniatyrosine hydroxylaseα-synucleinfatty acid-binding protein 3ubiquitinationproteasomal degradationubiquitin-proteasome systemmitochondriaE3 ubiquitin ligaseMITOL/MARCH5salt-sensitive hypertensionNedd4L/Nedd4-2epithelial sodium channelaldosterone sensitive distal nephronexcitation-transcription couplingRNF183RNF186RNF182RNF152RING fingermTORendoplasmic reticulum stressosmotic stressubiquitin codevirus infectionvirus-host interactiontau proteinsemisynthesisdisulfide-couplingpolyubiquitinfibrilsaggregationneurodegenerationdeubiquitinationinhibitorsprotein quality controlproteolysisprotein stabilizationregulatory T cellsmesenchymal stem cellcortical bone derived stem cellmyocardial infarctionblood pressurerenal salt reabsorptionvascular functionubiquitin proteasome systemubiquitin–proteasome pathwayciliaciliogenesisdifferentiationproliferationciliopathyE3sDUBsUPSneurodegenerative diseaseimmune-related diseasesHumanitiesSocial interactionIshigami Tomoakiedt1303374Ishigami TomoakiothBOOK9910557356403321Ubiquitination in Health and Diseases3026962UNINA