05212nam 2201129z- 450 991055735450332120231214133355.0(CKB)5400000000042345(oapen)https://directory.doabooks.org/handle/20.500.12854/76819(EXLCZ)99540000000004234520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdvances in DNA VaccinesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (210 p.)3-0365-0300-5 3-0365-0301-3 DNA is a rapidly developing vaccine platform for cancer and infectious and non-infectious diseases. Plasmids are used as immunogens to encode proteins to be further synthesized in vaccine recipients. DNA is mainly synthetic, ensuring enhanced expression in the cells of vaccine recipients (mostly mammalians). Their introduction into the host induces antibody and cellular responses. The latter are often more pronounced, and mimic the events occurring in infection, especially viral. There are a few distinct ways in which the vaccine antigen can be processed and presented, which determine the resulting immune response and which can be manipulated. Routinely, the antigen synthesized within the host cell is processed by proteasome, loaded onto, and presented in a complex with MHC I molecules. Processing can be re-routed to the lysosome, or immunogen can be secreted for further presentation in a complex with MHC II. Apart from expression, vaccination efficacy depends on DNA delivery. DNA immunogens are generally administered by intramuscular or intradermal injections, usually followed by electroporation, which enhances delivery 1000-fold. Other techniques are also used, such as noninvasive introduction by biojectors, skin applications with plasters and microneedles/chips, sonication, magnetofection, and even tattooing. An intense debate regarding the pros and cons of different routes of delivery is ongoing. A number of studies have compared the effect of delivery methods at the level of immunogen expression, and the magnitude and specificity of the resulting immune response. According to some, the delivery route determines immunogenic performance; according to others, it can modulate the level of response, but not its specificity or polarity. The progress of research aiming at the optimization of DNA vaccine design, delivery, and immunogenic performance has led to a marked increase in their efficacy in large species and humans. New DNA vaccines for use in the treatment of infectious diseases, cancer, allergies, and autoimmunity are forthcoming. This Special Issue covers various aspects of DNA vaccine development.MedicinebicsscEpidemiology & medical statisticsbicsscalphaviruseslayered RNA/DNA vectorsDNA vaccinesRNA repliconsrecombinant particlestumor regressionprotection against tumor challenges and infectious agentsebola virus diseaseartificial T-cell antigensDNA vaccine constructscomputer designgene expressionimmunogenicityDNA vaccinemRNA vaccineplasmid DNAin vitro transcribed mRNAimmune responsesformulationsCytolytic T Lymphocytesantibodiesinnate immunityadjuvantsvaccine deliveryplasmidcytolyticperforinbicistronicHCVHIVIL-36adjuvantDNAZikaEpstein-Barr viruslatent proteinsLMP2EBNA1LMP1HIV-1enhancer elementcircovirusinfluenzaimmunizationintranasallipidflagellinBCGvaccinerBCGHTIT-cellAIDSclinical trialtherapeutic vaccinehepatitis C virus (HCV)mesenchymal stem cells (MSC)modified MSCDNA immunizationnonstructural HCV proteinsimmune responseHCV vaccinemyeloid derived suppressor cells (MDSCs)MedicineEpidemiology & medical statisticsIsaguliants Mariaedt1323407Ljungberg KarledtIsaguliants MariaothLjungberg KarlothBOOK9910557354503321Advances in DNA Vaccines3035514UNINA04269nam 22006972 450 991079007720332120151005020622.01-139-06345-61-107-21365-71-283-11101-297866131110121-139-07578-00-511-92131-41-139-07804-61-139-07003-71-139-08033-41-139-08261-2(CKB)2670000000088899(EBL)691916(OCoLC)726734790(SSID)ssj0000520883(PQKBManifestationID)11312582(PQKBTitleCode)TC0000520883(PQKBWorkID)10516857(PQKB)10460326(UkCbUP)CR9780511921315(MiAaPQ)EBC691916(Au-PeEL)EBL691916(CaPaEBR)ebr10470829(CaONFJC)MIL311101(EXLCZ)99267000000008889920100927d2011|||| uy| 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierAnalytical sociology and social mechanisms /edited by Pierre Demeulenaere[electronic resource]Cambridge :Cambridge University Press,2011.1 online resource (ix, 320 pages) digital, PDF file(s)Title from publisher's bibliographic system (viewed on 05 Oct 2015).0-521-15435-9 0-521-19047-9 Introduction /Pierre Demeulenaere --Part I.Action and Mechanisms:1.Ordinary rationality: the core of analytical sociology /Raymond Boudon;2.Indeterminacy of emotional mechanisms /Jon Elster;3.A naturalistic ontology for mechanistic explanations in the social sciences /Dan Sperber;4.Conversation as mechanism: emergence in creative groups /R. Keith Sawyer --Part II.Mechanisms and Causality:5.Generative process model building /Thomas J. Fararo;6.Singular mechanisms and Bayesian narratives /Peter Abell;7.The logic of mechanismic explanations in the social sciences /Michael Schmid;8.Social mechanisms and explanatory relevance /Petri Ylikoski;9.Causal regularities, action and explanation/Pierre Demeulenaere --Part III.Approaches to Mechanisms:10.Youth unemployment: a self-reinforcing process? /Yvonne Åberg and Peter Hedström;11.Neighborhood effects, causal mechanisms, and the social structure of the city /Robert J. Sampson;12.Social mechanisms and generative explanations : computational models with double agents /Michael W. Macy with Damon Centola, Andreas Flache, Arnout van de Rijt and Robb Willer;13.Relative deprivation in Silico: agent-based models and causality in analytical sociology /Gianluca Manzo.Mechanisms are very much a part of social life. For example, we can see that inequality has tended to increase over time, and that cities can become segregated. But how do such mechanisms work? Analytical sociology is an influential approach to sociology which holds that explanations of social phenomena should focus on the social mechanisms that bring them about. This book evaluates the major features of this approach, focusing on the significance of the notion of mechanism. Leading scholars seek to answer a number of questions in order to explore all the relevant dimensions of mechanism-based explanations in social sciences. How do social mechanisms link together individual actions and social environments? What is the role of multi-agent modelling in the conceptualization of mechanisms? Does the notion of mechanism solve the problem of relevance in social sciences explanations?Analytical Sociology & Social MechanismsSociologySociologyMethodologySocial systemsSociology.SociologyMethodology.Social systems.301.01SOC026000bisacshDemeulenaere PierreUkCbUPUkCbUPBOOK9910790077203321Analytical sociology and social mechanisms3715868UNINA