04696nam 2201369z- 450 991055735420332120231214133332.0(CKB)5400000000042348(oapen)https://directory.doabooks.org/handle/20.500.12854/76822(EXLCZ)99540000000004234820202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer TherapyBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (307 p.)3-0365-1608-5 3-0365-1607-7 In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy.Medicinebicsschypoxiamacrophagescolon cancertumor microenvironmentimmune cell infiltrationprognosisfeline mammary carcinomaPD-1PD-L1CTLA-4TNF-αbiomarkersimmunotherapycancerhistone modificationinhibitorKDM5Bmolecular dockingrepurposingcancer acidityhyperosmolaritycross-presentationtumour microenvironmentsyngeneic modelprostate cancerradiotherapypreclinical modellingmyeloid-derived suppressor cellsbiomarkerstromacancer-associated fibroblast (CAF)extracellular matrix (ECM)cytokine/chemokinegrowth factorspro- and anti-tumor immune cellsimmunomodulatory rolesradiotherapy dose fractionationradioresistanceradiosensitivitybreast cancerS100A10 (p11)tumor growthtumor progressionmetastasiscarcinomamammary glandtriple negativepre-metastatic nichepro-inflammatory cytokinesclinical trialsevolutionary therapydarwinian evolutioncancer cells subpopulationsdiclofenackoningic acidspheroid3D co-culturemicroenvironmentresistancemyeloid cellscancer developmentmolecular subtypes of pancreatic cancerchemotherapy responsepancreatic stellate cellsregulatory T cellstumor-associated macrophagesmyeloid derived suppressor cellsglioblastoma (GB)Hypoxia Inducible Factor (HIF)glioma stem cells (GSC)oxidative stressreactive oxygen speciesplasminplasminogenS100A10uPAuPARPAI-1PAI-2cancer stem cellscancer recurrencetherapeutic resistancesignaling pathwaystargeted therapyhead and neck cancerlung cancerbladder cancerMedicineMadureira Patrícia Alexandra Saraivaedt1320364Madureira Patrícia Alexandra SaraivaothBOOK9910557354203321The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy3034191UNINA