04737nam 2201381z- 450 991055735420332120220111(CKB)5400000000042348(oapen)https://directory.doabooks.org/handle/20.500.12854/76822(oapen)doab76822(EXLCZ)99540000000004234820202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer TherapyBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (307 p.)3-0365-1608-5 3-0365-1607-7 In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy.Medicine and Nursingbicssc3D co-culturebiomarkerbiomarkersbladder cancerbreast cancercancercancer aciditycancer cells subpopulationscancer developmentcancer recurrencecancer stem cellscancer-associated fibroblast (CAF)carcinomachemotherapy responseclinical trialscolon cancercross-presentationCTLA-4cytokine/chemokinedarwinian evolutiondiclofenacevolutionary therapyextracellular matrix (ECM)feline mammary carcinomaglioblastoma (GB)glioma stem cells (GSC)growth factorshead and neck cancerhistone modificationhyperosmolarityhypoxiaHypoxia Inducible Factor (HIF)immune cell infiltrationimmunomodulatory rolesimmunotherapyinhibitorKDM5Bkoningic acidlung cancermacrophagesmammary glandmetastasismicroenvironmentmolecular dockingmolecular subtypes of pancreatic cancermyeloid cellsmyeloid derived suppressor cellsmyeloid-derived suppressor cellsoxidative stressPAI-1PAI-2pancreatic stellate cellsPD-1PD-L1plasminplasminogenpre-metastatic nichepreclinical modellingpro- and anti-tumor immune cellspro-inflammatory cytokinesprognosisprostate cancerradioresistanceradiosensitivityradiotherapyradiotherapy dose fractionationreactive oxygen speciesregulatory T cellsrepurposingresistanceS100A10S100A10 (p11)signaling pathwaysspheroidstromasyngeneic modeltargeted therapytherapeutic resistanceTNF-αtriple negativetumor growthtumor microenvironmenttumor progressiontumor-associated macrophagestumour microenvironmentuPAuPARMedicine and NursingMadureira Patrícia Alexandra Saraivaedt1320364Madureira Patrícia Alexandra SaraivaothBOOK9910557354203321The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy3034191UNINA