03701nam 2200985z- 450 991055734930332120220111(CKB)5400000000042397(oapen)https://directory.doabooks.org/handle/20.500.12854/77075(oapen)doab77075(EXLCZ)99540000000004239720202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMulti-Omics for the Understanding of Brain DiseasesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (204 p.)3-0365-2602-1 3-0365-2603-X Omics technologies such as proteomics, genomics, and metabolomics are widely applied for the identification and characterization of new molecular signatures. However, molecular profiling that makes it possible to understand neurodegenerative diseases has been relatively insufficient. Brain diseases such as neurodegenerative diseases and emotional disorders need integrative understanding which draws on a more reliable hypothesis for pathology, which can be accomplished via in-depth study of molecular information. Recently, multi-omics technologies have been eagerly applied to a diverse range of diseases. As this includes multiple molecular profiling, metadata, and Big Data processing with informatics and computer science, it is possible to provide new macroscopic and microscopic insights in order to better understand diseases. This Special Issue will introduce recent technological advances in multi-omics and the application of omics technology to brain diseases.Research & information: generalbicssc3D cultureabnormal behavior gene setageingAlzheimer's diseasebiomarkerbrainceramideschloride adductschromosome 22q11.21CNVcopy number variantCSFde novo mutationDGCR8differentially expressed genesepigeneticsepigenomeflow infusion analysisgenetic polymorphismglycerophosphocholineshuman brainhydrogen peroxidelab-on-chipmicrofluidicsmiRNAsmorphinen/aNAD+neurological diseasesneuroprotectiveneurotransmitternewborn infantnicotinamideOpenArrayorgan-on-chipOrthosiphon stamineusplant-derived proteinsplasmaPPIproteomicsregionschizophreniaSH-SY5Y cell modelSIDSspatiotemporal networksphingolipidssynaptic plasticitywithdrawalzinc finger domainzinc finger motifzinc finger proteinszinc metalloproteinsResearch & information: generalYoon Jongedt1325352Villa ChiaraedtYoon JongothVilla ChiaraothBOOK9910557349303321Multi-Omics for the Understanding of Brain Diseases3036788UNINA