04722nam 2201153z- 450 991055734620332120231214133622.0(CKB)5400000000042428(oapen)https://directory.doabooks.org/handle/20.500.12854/76476(EXLCZ)99540000000004242820202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPhysiology, Biochemistry, and Pharmacology of Transporters for Organic CationsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (248 p.)3-0365-0562-8 3-0365-0563-6 Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.Medicinebicssctransportersendogenous metabolismfunctional subgroupsSLC22remote sensing and signalingdrug transportersgut microbiomechronic kidney diseasesolute carrier 22 (SLC22)Remote Sensing and Signaling Theoryinterorgan communicationorganic anion transporterorganic cation transporterSLC22A15SLC22A16SLC22A18kidneyMalpighian tubuleTCGAhuman pathology atlasgene ontologyorganic cationstransportkidneysregulationNuclear receptorrenal excretionbile acidsorganic cation transportersdrug dispositiongenetic polymorphismsdrug-induced kidney injurynephrotoxicityRATofacitinibBaricitinibMATE1solute carrier (SLC) familyOCT1SLC22A1species differencesdrugspesticidescisplatin nephrotoxicityPPAR-alphaorganic transportersserotonin transporterplasma membrane monoamine transporterketamineisofluraneserotonin clearanceantidepressant-like activitychronoamperometrytail suspension testforced swim testhepatotoxicitysolute carrierpulmonary drug deliverySLC22A1-5lung epitheliumdrug uptakeβ2-agonistschronic lung diseasesanticholinergicstrospiumOCTMATEdrug excretiondrug transportMedicineCiarimboli Giulianoedt1314808Ciarimboli GiulianoothBOOK9910557346203321Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations3031994UNINA