04706nam 2201177z- 450 991055734540332120220111(CKB)5400000000042436(oapen)https://directory.doabooks.org/handle/20.500.12854/76632(oapen)doab76632(EXLCZ)99540000000004243620202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRadiation Response Biomarkers for Individualised Cancer TreatmentsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (231 p.)3-0365-1684-0 3-0365-1683-2 Personalised medicine is the next step in healthcare, especially when applied to genetically diverse diseases such as cancers. Naturally, a host of methods need to evolve alongside this, in order to allow the practice and implementation of individual treatment regimens. One of the major tasks for the development of personalised treatment of cancer is the identification and validation of a comprehensive, robust, and reliable panel of biomarkers that guide the clinicians to provide the best treatment to patients. This is indeed important with regards to radiotherapy; not only do biomarkers allow for the assessment of treatability, tumour response, and the radiosensitivity of healthy tissue of the treated patient. Furthermore, biomarkers should allow for the evaluation of the risks of developing adverse late effects as a result of radiotherapy such as second cancers and non-cancer effects, for example cardiovascular injury and cataract formation. Knowledge of all of these factors would allow for the development of a tailored radiation therapy regime. This Special Issue of the Journal of Personalised Medicine covers the topic of Radiation Response Biomarkers in the context of individualised cancer treatments, and offers an insight into some of the further evolution of radiation response biomarkers, their usefulness in guiding clinicians, and their application in radiation therapy.Medicinebicsscabscopal effectbiodosimetrybiological dosimetrybiomarkerbiomarkerscancercarbon-ion radiotherapycGASchromosomal instabilitychromosome aberrationscirculating biomarkerscirculating tumour cellsclonogenic assaysdicentric assayexosomesextracellular vesiclesgamma H2AX foci assayGC/MSgenotoxicity testshead and neck cancerhead-and-neck tumorshealth surveillance analyseshuman bloodimmune infiltrateimmune systemimmunotherapyIMRTindividual radiosensitivityinflammationinversionsionizing radiationlate effectsliquid biopsylung cancermachine learningmetabolomicsmethodsmicronucleimicronucleus assaymicroRNAmicroRNAsn/anormal tissuenormal tissue toxicityPBMCSpersonalized medicineplatingpneumonitispredictive testsprostate cancerproteinproteomicsradiationradiation-induced lung fibrosisradiation-induced lung injuryradiosensitivityradiotherapyradiotherapy monitoringrelative biological effectivenessRILFRILIserumsquamous cell carcinomaSTINGstromatelomerestumour microenvironmentuterine cervical cancerMedicineBadie Christopheedt1303371Rutten Eric AndreasedtBadie ChristopheothRutten Eric AndreasothBOOK9910557345403321Radiation Response Biomarkers for Individualised Cancer Treatments3026959UNINA