04233nam 2201093z- 450 991055734440332120231214133514.0(CKB)5400000000042447(oapen)https://directory.doabooks.org/handle/20.500.12854/76808(EXLCZ)99540000000004244720202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAnimal Modeling in CancerBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (273 p.)3-0365-1276-4 3-0365-1277-2 Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection EditorResearch & information: generalbicsscBiology, life sciencesbicsscsoyisoflavonesmammary tumor preventionrodent modelschemical carcinogenstransgenic miceZebrafishDrosophilaratsmiceNPM-1FLT3 ITDETO-1IDH1/2neural stem cellsbrain and nervous system cancersneurogenic nichesradiotherapysparing of neurogenic regionscarcinomaconsensus molecular subtypesintestineoncogenessignaling cascadestumor suppressorstumorigenesisMPN (myeloproliferative neoplasms)zebrafishiPSCsJAK2MPLCALRthrombosisubiquitin–proteasome systemcancermouse modelgene inactivationcolorectal cancermouse modelsmicrobiotaantitumor immunitymelanomamutationgeneticsanimal modelswineMeLiMprogressionspontaneous regressiondevitalizationmetaplasiaCdxanimal modelsepigeneticsxenotransplantationdrug screenpre-clinical cancer modelnon-mouse modelsgene editingstem cellssolid tumorshematologic malignanciesResearch & information: generalBiology, life sciencesKorinek Vladimiredt1313323Korinek VladimirothBOOK9910557344403321Animal Modeling in Cancer3031286UNINA