12895nam 2204489z- 450 991055733930332120220111(CKB)5400000000042485(oapen)https://directory.doabooks.org/handle/20.500.12854/76418(oapen)doab76418(EXLCZ)99540000000004248520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMarine Compounds and Cancer 2020Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (480 p.)3-0365-0630-6 3-0365-0631-4 The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U®), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.Medicine and Nursingbicssc12-deacetyl-12-epi-scalaradial3-alkylpyridinium polymersA375 and HeLa cell linesA549 cellsABC transporteractinomycinAD0157adriamycin resistanceAeroplysininAktangiogenesisangiogenesis inhibitoransamycinsanthranilic acidanti-angiogenesisanti-angiogenicanti-canceranti-metastatic activityanti-proliferationanti-proliferativeantiangiogenesisantiangiogenicantibacterialAntibody Drug Conjugates (ADCs)anticanceranticancer activityanticancer agentanticancer immunityanticarcinogenicanticoagulantanticoagulationantifoulingAntimicrobial peptide (AMP)antioxidantantiproliferativeantiproliferative activityantitumorantitumor activitiesantitumoralantitumourAP-1apoptosisapoptosis-inducing activityapproved antitumor agentsaraguspongine Carrest of cell cycleAspergillusautophagyautophagy inducersautophagy inhibitorsazoxymethaneBCRP/ABCG2BEL-7402 cellbenzo[a]pyrenebioactive natural productbioanalysisbis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM)bonnethead sharkbreast cancerbreast cancer cellsBrevianamidebrominated indolesbromophenolbuccal glandc-JUNc-MetC15 acetogeninscamptothecincancerCancercancer genescancer preventivecancer progressionCantabrian Sea-derived actinobacteriacarbocyclic analoguecarcinoembryonic antigenCaribbean spongecarotenoidcarotenoidscaspase cascadecell adhesioncell adhesion moleculescell cyclecell cycle arrestcell migrationcembranoidschemical conjugationchemopreventionchemopreventivechemosensitizationchemotherapychimeraCHOPchromatographycirculating tumor cellscisplatinclinical trialscolorectal cancercooperative bindingcyclin D1cyclin-dependent kinaseCYP1A1cystatin Fcystatin superfamilycytokine releasecytoskeletoncytotoxic activitycytotoxicitydeep-seadepolymerisationdibromotyrosinedieckoldivergolidesDNA minor groove binderdrug discoveryEcklonia cavaelisidepsinEMTendoperoxideendophytic fungusendothelial cellsenergy stressepigonal organepithelial-mesenchymal transitionER-stressET-743evolutionFAKfascaplysinfatty acid 2-hydroxylasefatty acidsFAUFBDDfucoidanfucoxanthinfumigaclavine Cgemcitabinegene expressionglioblastomagliotoxinglucocorticoid receptorglycosaminoglycansgorgonianHaliclona gracilisHeLa cellsheparan sulphateheparanasehepatocellular carcinomaHER2HIF-1hippuristanolHSP90human lung cancerhuman normal diploid fibroblast (TIG-1 cells)human sarcoma cell line (HT1080 cells)humulane sesquiterpenoidshybridizationhydroxylated lipidshypoxiahypoxia-inducible factor-1IL-6in vivo modelinflammationinhibitorintegrin β1invasionisatinIsofistularinitampolin Ajaspine BJNK1/2Jurkatkalkitoxinkunitz type inhibitorLampetra moriiLeathesia nanaLeptogorgialeukemialipid raftslow molecular weight fucoidan extractlow toxicLS-1lung cancerlung metastasisLyngbya majusculamacrolidemangrove-derived actinomycetemanzamine AMAPK/ERK pathwaymarangucyclinesmarine antitumor agentsmarine biotechnologymarine compoundmarine drugmarine drugsmarine fungusmarine metabolitesmarine molluscmarine natural productsmarine organismsmarine spongesmarine-derived drugsMarthasterias glacialis L.MCP-1mechanisms of actionmelanomamembrane permeabilizationmetastasismicroalgaeMicromonosporamigrationmitochondriamitochondria toxinmitochondrial pathwaymitochondrial dysfunctionmolecular dockingmolecular mechanismsmolecular modelingmolecular oncologyMoorea producensMRP1/ABCC1multi-drug resistant leukemiamultidrug resistanceMycalin AMycochromenic acid derivativeN-Rasn/ananoparticlenaphthopyronesnatural marine compoundsnatural productnatural productsneuroblastoma-rat sarcomaNF-κBNF-κB signalingnicotinenicotinic acetylcholine receptornon-small cell lung cancernon-small cell lung cancer (NSCLC)non-small cell lung carcinomanonfunctioning pituitary adenomasnovel inhibitorNSCLCNur77osteosarcomaoxidative stressoxidative stressP-gp/ABCB1P2X7 receptorp38p38/ERKp38αp65pachastrissaminepalmitic acidpaulomycinspazopanibPELPenicillium brevicompactumPenicillium paneumphase Ipheochromocytoma and paragangliomaphlorotanninsphycocyaninPI3K/Aktplakortideplitidepsinpollutionpoly(ADP-ribose)-polymerase inhibitorpolyoxygenated steroidspolyphenolspolysaccharidesPoriferaporifera/spongepreclinicalprogrammed cell deathprogrammed cell death-ligand 1programmed cell death-ligand 2proliferationprostate cancerproteasomal degradationproteomicpseudopterosinpuupehenonespyrrolidinedionereactive oxygen speciesRGD motifribosomal protein genesROSRPS30safetySarcophyton ehrenbergisea anemonesea cucumbersseaweedsecondary metabolitessedimentselenium-containing polysaccharide-protein complexSepia ink polysaccharidesshrimpsignal transductionsinulariolidesipholenol Asmall cell lung cancerSNORA62snoRNASNU-C5/5-FUsoft coralsoft tissue sarcomasoft tissue sarcomasphingosine kinase inhibitorspongespongesSTAT3Streptomyces sp. SCSIO 11594synergismsynthetic analoguesSZ-685Ctargeted therapyterpenestetracenomycin XTGF-β signalingThalassia testudinumthalassiolin Btherapeutic compoundsTilapia piscidin 4 (TP4)TNFαTopo I inhibitortopoisomerasetrabectedintriterpene glycosidesTRPM7tumor cell linetumor microenvironmenttumor-associated macrophagesUlva fasciatauveal melanomaVEGFvirtual screeningxyloketal Bα9-nicotinic acetylcholine receptors (nAChRs)αO-conotoxin GeXIVAβ1-integrinλ-carrageenanMedicine and NursingHonecker Friedemannedt1322902Dyshlovoy Sergey AedtHonecker FriedemannothDyshlovoy Sergey AothBOOK9910557339303321Marine Compounds and Cancer 20203035241UNINA