12834nam 2204465z- 450 991055733930332120231214133147.0(CKB)5400000000042485(oapen)https://directory.doabooks.org/handle/20.500.12854/76418(EXLCZ)99540000000004248520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMarine Compounds and Cancer 2020Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (480 p.)3-0365-0630-6 3-0365-0631-4 The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U®), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.Medicinebicsscapoptosisfucoidanhepatocellular carcinomareactive oxygen species3-alkylpyridinium polymersnicotinenicotinic acetylcholine receptornon-small cell lung carcinomamelanomasinulariolideproteomicmitochondriacaspase cascademarine fungussedimentanthranilic acidPenicillium paneumcytotoxicitydibromotyrosinemitochondrial dysfunctionoxidative stresstopoisomeraseepigonal organbonnethead sharkJurkattumor cell linehippuristanolPELAP-1STAT3Aktcolorectal cancermarine molluscbrominated indolesshrimpchemopreventionfatty acidscarotenoidscancernanoparticleosteosarcomalung metastasiselisidepsinlipid raftshydroxylated lipidsfatty acid 2-hydroxylasecooperative bindingmembrane permeabilizationmarine organismspolysaccharidesanticanceranticarcinogenicmechanisms of actionfumigaclavine Canti-proliferationmitochondrial pathwayanti-canceranti-proliferativecarotenoidcell cycle arrestfucoxanthinazoxymethanebioactive natural productisatinin vivo modelMarthasterias glacialis L.palmitic acidER-stressCHOPAntibody Drug Conjugates (ADCs)marine antitumor agentsclinical trialsapproved antitumor agentsAD0157angiogenesismarine drugpyrrolidinedionesecondary metabolitescancer preventivechemopreventivetrabectedinplitidepsintumor-associated macrophagestumor microenvironmentpreclinicalanticancer immunityantiangiogenesisfascaplysincyclin-dependent kinasesmall cell lung cancercamptothecinpoly(ADP-ribose)-polymerase inhibitorbreast cancerseaweedtherapeutic compoundsautophagymarine drugsautophagy inhibitorsautophagy inducersmacrolideprogrammed cell deathenergy stressaraguspongine Cc-MetHER2gemcitabinepazopanibphase Isafetysoft tissue sarcomapachastrissaminejaspine Bcarbocyclic analoguesphingosine kinase inhibitormolecular modelingET-743DNA minor groove bindersoft tissue sarcomachemotherapybis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM)anti-metastatic activitycell adhesionβ1-integrinFAKBEL-7402 celltriterpene glycosidessea cucumbersantitumor activitiesarrest of cell cycleantibacterialmarangucyclinesdeep-seaStreptomyces sp. SCSIO 11594LS-1SNU-C5/5-FUTGF-β signalingcarcinoembryonic antigenkalkitoxinMoorea producensmitochondria toxinVEGFangiogenesis inhibitorhypoxia-inducible factor-1HIF-1Lyngbya majusculamarine metabolitesSZ-685Cnonfunctioning pituitary adenomasEcklonia cavaphlorotanninsdieckolmigrationsipholenol AABC transportermultidrug resistanceP-gp/ABCB1BCRP/ABCG2MRP1/ABCC1marine natural productsglioblastomaxyloketal BproliferationTRPM7marine compoundribosomal protein genessnoRNAFAURPS30SNORA62evolutionPoriferaPenicillium brevicompactumBrevianamideMycochromenic acid derivativeantifoulingCaribbean spongeplakortideendoperoxideleukemiamulti-drug resistant leukemiaSarcophyton ehrenbergisoft coralterpenescembranoidscytotoxic activitymolecular dockinguveal melanomaoxidative stressvirtual screeningTopo I inhibitorlow toxicnatural productUlva fasciataselenium-containing polysaccharide-protein complexpseudopterosinNF-κBp65inflammationcytokine releaseIL-6TNFαMCP-1glucocorticoid receptorpaulomycinsMicromonosporaantitumorCantabrian Sea-derived actinobacteriapuupehenonesspongesantiangiogenicantitumoralporifera/spongecancer genesmolecular oncologybromophenolmolecular mechanismscell cyclePI3K/Aktp38/ERKROShuman lung cancerglycosaminoglycansantiproliferativeheparan sulphategliotoxinNSCLCadriamycin resistanceSepia ink polysaccharidesantitumourchemosensitizationanticoagulationsea anemonedrug discoveryendothelial cellsRGD motifkunitz type inhibitorprostate cancerantioxidantnatural marine compoundsmarine biotechnologymicroalgaemarine spongesAeroplysininIsofistularinpheochromocytoma and paragangliomametastasiscancer progressioncell adhesion moleculesintegrin β1hypoxiaphycocyaninnon-small cell lung cancerNF-κB signalingmarine-derived drugsbioanalysischromatographymanzamine Aepithelial-mesenchymal transitionlung cancercirculating tumor cellssignal transductioncisplatinLampetra moriibuccal glandcystatin Fanti-angiogenesiscystatin superfamilyAntimicrobial peptide (AMP)Tilapia piscidin 4 (TP4)non-small cell lung cancer (NSCLC)itampolin AFBDDp38αnovel inhibitortetracenomycin Xcyclin D1proteasomal degradationp38c-JUNλ-carrageenanheparanaseanticoagulantdepolymerisationcell migrationAspergillusnaphthopyronesendophytic fungusLeathesia nanamangrove-derived actinomyceteansamycinsdivergolidesapoptosis-inducing activityactinomycinEMTinvasionlow molecular weight fucoidan extractN-Rasneuroblastoma-rat sarcomaCancerprogrammed cell death-ligand 1programmed cell death-ligand 2human sarcoma cell line (HT1080 cells)human normal diploid fibroblast (TIG-1 cells)chimerachemical conjugationanticancer agenthybridizationα9-nicotinic acetylcholine receptors (nAChRs)breast cancer cellsαO-conotoxin GeXIVAtargeted therapygorgonianLeptogorgiahumulane sesquiterpenoidsanticancer activity12-deacetyl-12-epi-scalaradialHeLa cellsNur77MAPK/ERK pathwayMycalin AC15 acetogeninssynthetic analoguesantiproliferative activityA375 and HeLa cell linespolyoxygenated steroidsspongeHaliclona gracilisThalassia testudinumthalassiolin BpolyphenolsCYP1A1benzo[a]pyreneJNK1/2natural productssynergismA549 cellscytoskeletonP2X7 receptorpollutionanti-angiogenicgene expressionHSP90inhibitorMedicineHonecker Friedemannedt1322902Dyshlovoy Sergey AedtHonecker FriedemannothDyshlovoy Sergey AothBOOK9910557339303321Marine Compounds and Cancer 20203035241UNINA