04330nam 2201105z- 450 991055730770332120231214133454.0(CKB)5400000000042779(oapen)https://directory.doabooks.org/handle/20.500.12854/69113(EXLCZ)99540000000004277920202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Alveolar EpitheliumMechanisms of Injury and RepairBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (222 p.)3-03943-166-8 3-03943-167-6 Alveolar epithelial cells (AECs) of the lung are important contributors to pulmonary immune functions and to pulmonary development and alveolar repair mechanisms following lung injury. AECI, together with the capillary endothelium, form the extremely thin barrier between alveolar air and blood. AECII produce and metabolize the surface-tension lowering and immune-modulating surfactant and are the progentiors of AECI. A great variety of processes rely on their normal functioning, including maintenance of the alveolar barrier; innate immune defense; and processes of differentiation, senescence, apoptosis, and autophagy. The wide range of AEC functions is nicely reflected by the diversity of topics addressed by the four review and eight original articles contained in this Special Issue of the International Journal of Molecular Sciences. Beyond the broad spectrum of topics, the authors of this issue also made use of an impressive variety of analytical methods, thus further illustrating the fascinating diversity of aspects related to AEC biology.Alveolar Epithelium Research & information: generalbicsscBiology, life sciencesbicsscJAM-AP2X7 receptormouse lungalveolar epitheliumbleomycin-induced lung injuryGSK-3βdietary sugarhyperglycemialung mechanicsalveolar septal compositionphysical activityextracellular matrix remodelinghigh-altitude pulmonary edemaacute mountain sicknessoxygen diffusion limitationsurfactant protein Batelectraumaalveolar fluidacinar micromechanicsacute lung injuryautophagylysosomelysosomal membrane permeabilitymitochondriapneumocytemicroRNA-21alveolar micromechanicsstructural remodelinginflammatory signalinglungalveolustype 1 alveolar epithelial celltype 2 alveolar epithelial cellfocused ion beam scanning electron microscopy3D reconstructioncarbon dioxidehypercapniaNa,K-ATPaseendoplasmic reticulumsodium transportprotein oxidationalveolar epithelial cellspulmonary fibrosisepithelial cell dysfunctionstem cell exhaustionpneumonianecrotizingregenerationmodelbovinechlamydiaalveoliair-blood barrierepitheliumair-liquid interfacealveolar lining layerglycocalyxsurfactantlung injurylung regenerationResearch & information: generalBiology, life sciencesKasper Michaeledt1328754Mühlfeld ChristianedtKasper MichaelothMühlfeld ChristianothBOOK9910557307703321The Alveolar Epithelium3038905UNINA