03850nam 2200865z- 450 991055730380332120231214133158.0(CKB)5400000000042818(oapen)https://directory.doabooks.org/handle/20.500.12854/69297(EXLCZ)99540000000004281820202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPeriodontitisFrom Dysbiotic Microbial Immune Response to Systemic InflammationBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (122 p.)3-03943-507-8 3-03943-508-6 Periodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate and release virulence factors, they cause an imbalance in the host inflammatory response that induces degenerative processes in the surrounding tissues. This process is often slow, and the disease affects mainly older people, but the process could be rapid and affect young individuals if certain pathogens colonize the area. The two most studied periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, express virulence factors, including proteases and exotoxins. Periodontal bacteria and their products can be translocated to the peripheral circulation and are therefore linked to the risk pattern of several systemic diseases. However, it is not known if the increased risk for systemic disease associated with periodontitis is an effect of the invading bacteria and/or their released products, the release of components from the local inflammatory response, or a common host susceptibility pattern. The most studied periodontitis-associated systemic diseases are cardiovascular diseases and rheumatoid arthritis. Here, we want to shed light on mechanisms behind the associations of periodontal infections with systemic inflammation.Periodontitis Medicinebicsscapical periodontitisadaptive immunitysalivaserumantibodyAggregatibacter actinomycetemcomitansinvasivenessleukotoxincytolethal distending toxinserum resistanceouter membrane vesiclesoral microbiomenitric oxidenitratenitriteperiodontal diseasealveolar bone lossgingivabacteriabiofilmimmunityinflammationsmokingRheumatoid arthritisPorphyromonas gingivalisperiodontitiscitrullinationpeptidylarginine deiminaseACPAanti-CCPhost responseinfectionoral microbiotavirulence factorsmetabolitesTREM-1interventionLP17IL-17RANKLOPGcardiovascular diseasesrheumatoid arthritisinflammatory responseMedicineJohansson Andersedt1161470Johansson AndersothBOOK9910557303803321Periodontitis3018837UNINA