04339nam 2201237z- 450 991055729750332120210501(CKB)5400000000041064(oapen)https://directory.doabooks.org/handle/20.500.12854/68511(oapen)doab68511(EXLCZ)99540000000004106420202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierZika Virus and Host InteractionsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (256 p.)3-03943-949-9 3-03943-950-2 Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV-host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design.Biology, life sciencesbicsscResearch and information: generalbicsscanti-viral signalingapoptosisarbovirusesastrocytesBcl-2 protein familyblood-placental barrierC6/36 cellscell deathcell entrycellular communicationclaudinscytokineendothelial vascular cellsenvelope proteinextracellular vesiclesfetal brainflavivirusflavivirusesfusion loopglycosylationguinea pighosthost-pathogen interactionsHSP90human monocytesIFNIFNAR1immune responseinfertilityinflammationinflammatory mediatorinnate immune responseinnate immunityinterferonJAK/STATLeydig cellsMDA5mosquitoMR766networknon-structural viral proteinsNS5NS5 proteinnuclear localizationpathogenesisperoxisomeperoxisomesplacentaprotein-protein interactionRIG-ISertoli cellssexual transmissionsubcutaneousT cellstight junctiontight junctionsvaginalviral fusionviral replicationvirus host interactionsvirus transmissionvirus-host interactionsWest Nile viruszikazika virusZika virusZIKA virusZIKVZO-1Biology, life sciencesResearch and information: generalHobman Tomedt1283267Kumar AniledtLimonta DanieledtHobman TomothKumar AnilothLimonta DanielothBOOK9910557297503321Zika Virus and Host Interactions3019085UNINA