04248nam 2201105z- 450 991055734440332120220111(CKB)5400000000042447(oapen)https://directory.doabooks.org/handle/20.500.12854/76808(oapen)doab76808(EXLCZ)99540000000004244720202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAnimal Modeling in CancerBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (273 p.)3-0365-1276-4 3-0365-1277-2 Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection EditorBiology, life sciencesbicsscResearch & information: generalbicsscanimal modelanimal modelsantitumor immunitybrain and nervous system cancersCALRcancercarcinomaCdxchemical carcinogenscolorectal cancerconsensus molecular subtypesdevitalizationDrosophiladrug screenepigeneticsETO-1FLT3 ITDgene editinggene inactivationgeneticshematologic malignanciesIDH1/2intestineiPSCsisoflavonesJAK2mammary tumor preventionmelanomaMeLiMmetaplasiamicemicrobiotamouse modelmouse modelsMPLMPN (myeloproliferative neoplasms)mutationneural stem cellsneurogenic nichesnon-mouse modelsNPM-1oncogenespre-clinical cancer modelprogressionradiotherapyratsrodent modelssignaling cascadessolid tumorssoysparing of neurogenic regionsspontaneous regressionstem cellsswinethrombosistransgenic micetumor suppressorstumorigenesisubiquitin-proteasome systemxenotransplantationzebrafishZebrafishBiology, life sciencesResearch & information: generalKorinek Vladimiredt1313323Korinek VladimirothBOOK9910557344403321Animal Modeling in Cancer3031286UNINA05074nam 2201285z- 450 991055729700332120210501(CKB)5400000000041069(oapen)https://directory.doabooks.org/handle/20.500.12854/69241(oapen)doab69241(EXLCZ)99540000000004106920202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierWater Quality of Freshwater Ecosystems in a Temperate ClimateBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (282 p.)3-03943-414-4 3-03943-415-2 This Special Issue consists of fourteen original scientific articles concerning different problems associated with the water quality of freshwater ecosystems in a temperate climate. Most of the articles deal with the relationship between water quality and the structure of ecosystem biocenoses. The conclusion of these articles confirms the fact that the deterioration of water quality has a direct impact on the quantitative and qualitative structure of biocenoses. This is accompanied by a decline in biodiversity and the disappearance of rare plant and animal species. They also draw attention to the particular importance of internal physical and chemical differentiation within the aquatic ecosystem, both in horizontal and vertical dimensions. The problem of ensuring proper ecological conditions and good quality of water in freshwater aquatic ecosystems is also raised, and various methods for the restoration of water bodies are presented. This Special Issue contributes to a better understanding of the causes of water quality deterioration, the mechanisms responsible for the functioning of ecosystems, including the decrease of biodiversity and the possibilities of improving their condition. Thus, it can be helpful for regaining the good ecological status of water bodies required by the Water Framework Directive.Research and information: generalbicsscagricultureanthropogenic impactaquatic plantsaquatic vegetationassemblagebiodiversitybiomanipulationCarabidaecatchmentChironomidaechlorophyll-aciliate assemblagesCladoceraclimate changecyanobacteriaDaphniadiatomsdiversityecological assessmentecological optimumEuropean Water Framework Directiveeutrophicationfloodplain lakesfreshwater ecosystems restorationfreshwater habitatsfunctional groups of phytoplanktonharmful algal bloom mitigationhuman impacthuman-induced impacthydrological regimehypolimnion aerationinnovative method of restorationinvertebratesIsoëtes lacustrislakeLittorella unifloraLobelia dortmannamacroinvertebratesmeromictic lakemetalsmicrocrustaceansmulti-proxy approachNorthern Europenutrient loadnutrientsovergrownoxygen concentrationoxygenation near the bottom sedimentsphosphorus inactivationphytoneustonphytoplanktonphytoplankton biomassplankton assemblagesrainfall variabilityreactive oxygen specierestoration treatmentriverbanksriverbed regulationrotifersshallow lakesmall lakesmall water bodiessoft water lakespringsstenotopic speciesstratified lakestream ecologystrontium isotopessurface microlayersustainable restorationurban water bodywater bodieswater cyclewater level fluctuationwater qualityWest AfricazooplanktonResearch and information: generalGołdyn Ryszardedt1283266Klimaszyk PiotredtGołdyn RyszardothKlimaszyk PiotrothBOOK9910557297003321Water Quality of Freshwater Ecosystems in a Temperate Climate3019084UNINA