04759nam 2201165z- 450 991055729510332120210501(CKB)5400000000041088(oapen)https://directory.doabooks.org/handle/20.500.12854/69348(oapen)doab69348(EXLCZ)99540000000004108820202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRadiolabelled Molecules for Brain Imaging with PET and SPECTBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (244 p.)3-03936-720-X 3-03936-721-8 Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are labeled with radionuclides of short half-lives that are synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. The use of PET and SPECT for brain imaging is of special significance since the brain controls all the body's functions by processing information from the whole body and the outside world. It is the source of thoughts, intelligence, memory, speech, creativity, emotion, sensory functions, motion control, and other important body functions. Protected by the skull and the blood-brain barrier, the brain is somehow a privileged organ with regard to nutrient supply, immune response, and accessibility for diagnostic and therapeutic measures. Invasive procedures are rather limited for the latter purposes. Therefore, noninvasive imaging with PET and SPECT has gained high importance for a great variety of brain diseases, including neurodegenerative diseases, motor dysfunctions, stroke, epilepsy, psychiatric diseases, and brain tumors. This Special Issue focuses on radiolabeled molecules that are used for these purposes, with special emphasis on neurodegenerative diseases and brain tumors.Biology, life sciencesbicsscResearch and information: generalbicssc[18F]FESCH[18F]UCB-Hadenosine A2A receptoralpha 7Alzheimer's diseaseAlzheimer's disease (AD)amino acidautoradiographyBenzoimidazotriazine (BIT)biomarkersblocking assaybrain metastasesbrain networkcyclic nucleotide phosphodiesterasediagnostic imaging probesdistribution volumedrug dependenceepilepsyFACBCFDOPAFETfluorinatedfluorine-18GBMgliomagraph theoryIDHimagingimmunoPETin vitro autoradiographymicroPETmolecular imagingMouse Liver Microsomes (MLM)movement disordersnAChRnetwork measureneurofibrillary tanglesnicotinic acetylcholine receptorsnitro-precursoropioid receptorsorexin receptorspainParkinson's diseasePARPPBIFPD-L1PDE2A radioligandpersistent homologyPETPET imagingPhosphodiesterase 2A (PDE2A)positron emission tomographypositron emission tomography (PET)Positron Emission Tomography (PET)preclinical imagingradiotracerradiotracersrotenone-based mouse modelSigma 1Sigma 2SV2ASV2BSV2Ctwo-step one-pot radiosynthesisα-synucleinopathyβ-amyloid plaquesμOR-, δOR-, κOR- and ORL1-ligandsBiology, life sciencesResearch and information: generalBrust Peteredt1291783Brust PeterothBOOK9910557295103321Radiolabelled Molecules for Brain Imaging with PET and SPECT3021916UNINA