02023nam 2200541I 450 991070763500332120161011105325.0(CKB)5470000002466190(OCoLC)960356617(EXLCZ)99547000000246619020161011j199707 ua 0engurbn|||||||||txtrdacontentcrdamediacrrdacarrierEffects of compression, staging, and braid angle on braided rope seal performance /Bruce M. Steinetz and Michael L. AdamsCleveland, Ohio :National Aeronautics and Space Administration, Lewis Research Center,July 1997.1 online resource (11 pages) illustrationsNASA technical memorandum ;107504"July 1997"--Report documentation page."Prepared for the 33rd Joint Propulsion Conference and Exhibit cosponsored by AIAA, ASME, SAE, and ASEE, Seattle, Washington, July 6-9, 1997.""Performing organization: National Aeronautics and Space Administration, Lewis Research Center"--Report documentation page."AIAA-97-2872."Includes bibliographical reference (page 7).Seals (stoppers)nasatCeramicsnasatCompression testsnasatDurabilitynasatBraided compositesnasatStiffnessnasatPrestressingnasatSeals (stoppers)Ceramics.Compression tests.Durability.Braided composites.Stiffness.Prestressing.Steinetz Bruce M.1393619Adams Michael L.Lewis Research Center,GPOGPOBOOK9910707635003321Effects of compression, staging, and braid angle on braided rope seal performance3519088UNINA03915nam 2200817z- 450 991055729170332120210501(CKB)5400000000041122(oapen)https://directory.doabooks.org/handle/20.500.12854/69072(oapen)doab69072(EXLCZ)99540000000004112220202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNewborn Screening for Cystic FibrosisBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (126 p.)3-03936-990-3 3-03936-991-1 The introduction and widespread implementation of newborn bloodspot screening (NBS) for cystic fibrosis (CF) has offered earlier diagnosis and better outcomes for children with CF in many countries of the world. It represents a paradigm shift in the diagnostic pathway for these families. In contrast to a clinical diagnosis, infants are now referred for diagnostic testing after a positive NBS result. The introduction of NBS has enabled the provision of early appropriate treatment to prevent the manifestations of the disease. In the near future, early diagnosis will facilitate the prompt use of new CFTR modulator therapies that correct the basic underlying molecular defect. NBS for CF has been a global success but continues to raise questions with many varied approaches and the development of new technologies, in particular the ability to undertake extensive gene examination. Which is the best protocol to achieve high sensitivity and specificity, and how to evaluate and manage infants with inconclusive diagnosis are all subjects of ongoing discussion. It is also open to question: what is the best approach to informing and counselling the parents about a positive or inconclusive NBS result? These questions are not easy to answer and require a balanced solution that reflects the local health care system and may appropriately result in different answers around the globe. The articles in this book try to answer these questions and give an overview of the current state of knowledge in NBS for CF.Medicinebicsscbiochemical screeningbioethicsCF screen positiveCF transmembrane conductance regulator-related metabolic syndromeCFSPIDcostcystic fibrosiscystic fibrosis screen positivediagnosisDNADNA analysisdried blood spotextended genetic analysishealth policyimmunoreactive trypsinimmunoreactive trypsin(ogen)immunoreactive trypsinogenincidenceinconclusive diagnosisinconclusive diagnosis (CFSPID)malnutritionmeconium ileusmissed casen/anewborn bloodspot screeningnewborn screennewborn screeningnext generation sequencingpancreatitis associated proteinparental informationpresumptive diagnosisprognosispsychological impactradioimmunoassaysensitivitysweat testtarget disordertherapyMedicineBarben Jürgedt1293814Southern KevinedtBarben JürgothSouthern KevinothBOOK9910557291703321Newborn Screening for Cystic Fibrosis3022739UNINA