04017nam 2201081z- 450 991055728920332120231214133239.0(CKB)5400000000041148(oapen)https://directory.doabooks.org/handle/20.500.12854/69361(EXLCZ)99540000000004114820202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierImmunophenotyping in Autoimmune Diseases and CancerBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (170 p.)3-03943-466-7 3-03943-467-5 The cooperation of highly specialized cell types maintains the homeostasis of multicellular organisms. The disturbance of that harmony contributes to the development of several diseases. Most of the cellular functions are executed by proteins, so it is essential to investigate biological processes at the protein level. Antibodies, complex biomolecules with high specificity, are used to recognize our protein of interest in a process known as “immunophenotyping”. One of the routinely used methods to study cellular proteins is flow cytometry, which detects cell surface or intracellular proteins at single-cell resolution. The other most frequent technique is the traditional immunohistochemical investigation of microscopic sections of human tissues. We called authors to publish their latest data studying cancer or autoimmune diseases by immunophenotyping.MedicinebicsscCD8+CD28− T cellscancer immunologyglioblastomaimmunotherapymalignant gliomacanceraccidental cell deathoncosisDDRparthanatosflow cytometrysystemic lupus erythematosusT cellsglycosylationsialylationlectin bindingglycosylation enzymesgalectin 1choriocarcinomahydatidiform molegalectingestational trophoblastic diseaseplacental-specific genesystems biologytrophoblast differentiationB cellsnon-switched B cellssystemic sclerosisdcSScTLRCD180RP105CpGIL-6IL-10natural autoantibodiesIgMcitrate synthaseDNA topoisomerase Iunfolded protein responseInositol-requiring enzyme 1 (IRE1)PKR-like endoplasmic reticulum kinase (PERK)Glucose-regulated protein 78 (GRP78)Activating transcription factor 6 (ATF6)immune cellsT cellmacrophagetumor microenvironmentsingle cell mass cytometrymetastatic breast cancermyeloid-derived suppressor cellsimmunophenotypingbreast cancertrastuzumabchimeric antigen receptorcell therapyneuroendocrine neoplasianeuroendocrine tumorneuroendocrine carcinomaimmunohistochemistrysyntaxin 1MedicineSzebeni Gábor Jedt1302202Puskás László GedtSzebeni Gábor JothPuskás László GothBOOK9910557289203321Immunophenotyping in Autoimmune Diseases and Cancer3026244UNINA