02841nam 2200493z- 450 991055725490332120211118(CKB)5400000000041408(oapen)https://directory.doabooks.org/handle/20.500.12854/73765(oapen)doab73765(EXLCZ)99540000000004140820202111d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCritical Zone (CZ) Export to Streams as Indicator for CZ Structure and FunctionFrontiers Media SA20201 online resource (131 p.)2-88963-623-2 The goal of this Research Topic on streams as indicators for CZ structure and function is to explore linkages between biotic and abiotic weathering, soil biogeochemical processes, chemical and physical denudation and hydrology within the CZ. The CZ spans from the top of the vegetative canopy to the actively cycled groundwater providing life sustaining ecosystem services. However, rapid population growth and global climate change during the Anthropocene poses challenges to the Earth's CZ which is pushed to balance increased demand (e.g. crop yield) while maintaining the CZ's natural structure and other important ecosystem functions. Streams represent an integrator of many processes within the CZ and can thus carry the first signals of changing CZ health. As an important component of the CZ system, streams provide important information on hydrological, biogeochemical, and denudation fluxes, allowing a glimpse into the past, present and potential future of CZ function. The foci of recent stream water investigations include the role of catchment processes, riparian zone dynamics, hyporheic zone contributions and instream cycling to investigate nutrient dynamics, weathering and denudation, and hydrological partitioning. We now would like to expand this view conceptually to include the CZ.Critical Zone Physical geography and topographybicsscScience: general issuesbicssccatchmentcritical zoneinterdisciplinarystreamsystemPhysical geography and topographyScience: general issuesPerdrial Juliaedt1327900Dere AshleeedtWest NicoleedtSullivan Pamela LedtPerdrial JuliaothDere AshleeothWest NicoleothSullivan Pamela LothBOOK9910557254903321Critical Zone (CZ) Export to Streams as Indicator for CZ Structure and Function3038253UNINA04419nam 2201345z- 450 991055771720332120210501(CKB)5400000000046153(oapen)https://directory.doabooks.org/handle/20.500.12854/68994(oapen)doab68994(EXLCZ)99540000000004615320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMatrix MetalloproteinaseBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (262 p.)3-03936-648-3 3-03936-649-1 Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.Biology, life sciencesbicsscResearch & information: generalbicssca disintegrin and metalloproteinaseADAMADAMTSadultaggrecanaggrecanaseAgkistrodon venomallodyniaanticoagulantsantithromboticapoptosisarthritisblood samplingcancercartilagecaspase-3CD147central nervous systemchemokinecytokinecytokinesdiseasesdorsal root ganglionectodomain sheddingEMMPRINextracellular matrixextracellular matrix breakdownfibrinogengastric cancerglycosaminoglycansglycosylationhemagglutinin-Bhigh-molecular-weight heparinHIV-TB-associated IRISIL-11IL-16IL-6IL-8inflammationinhibitorinterferoninterleukininterstitial collagensinvasionlungmatrix metalloproteinasematrix metalloproteinasesmatrix metalloproteinases (MMPs)matrix-metalloproteinasemeprinmetabolomicsmetalloproteasesmetalloproteinasemetastatic disseminationMMPMMP-2MMP-9MMPsmonocytesMT4-MMPneuropathicpainpediatricperitoneal mesothelial cellphagocytosisphosphorylationproteaseproteinasesproteomicsPTMssICAM-1signalingspinal nerve ligationT cellsTNF-αtrans-signalingtranswell co-culturestuberculosistuberculous meningitiswound healingBiology, life sciencesResearch & information: generalÅgren Magnus Sedt1309861Keller UlrichedtÅgren Magnus SothKeller UlrichothBOOK9910557717203321Matrix Metalloproteinase3029672UNINA