02703nam 2200469z- 450 991055722110332120211118(CKB)5400000000041733(oapen)https://directory.doabooks.org/handle/20.500.12854/73730(oapen)doab73730(EXLCZ)99540000000004173320202111d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierVitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological ConditionsFrontiers Media SA20201 online resource (86 p.)2-88963-578-3 There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form. While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment. In this Research Topic, we provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases.EndocrinologybicsscMedicine and Nursingbicssc125-dihydroxyvitamin Dbioavailable 25-hydroxyvitamin Dfree 25-hydroxyvitamin Dtotal 25-hydroxyvitamin Dvitamin D binding proteinEndocrinologyMedicine and NursingDavid Bikle Danieledt1278459Xie ZhongjianedtWang XiangbingedtDavid Bikle DanielothXie ZhongjianothWang XiangbingothBOOK9910557221103321Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions3013294UNINA