04971nam 2201249z- 450 991055714810332120210501(CKB)5400000000040577(oapen)https://directory.doabooks.org/handle/20.500.12854/68388(oapen)doab68388(EXLCZ)99540000000004057720202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMetabolism and Metabolomics of Liver in Health and DiseaseBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (268 p.)3-03943-635-X 3-03943-636-8 Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.Medicine and Nursingbicssc1H-NMR spectroscopyacetaminophenacupuncturealcoholic liver diseasearachidonic acidbile acidsbiomarkerbloodcarbohydrate response element-binding proteincellscholestasisChREBPcirrhosisde novo lipogenesisdiabetesdocosahexaenoic acidfecesfibrosisFibrosisGC-MSGenomicsglucose homeostasisglucose productionglycogenglycogen storage disease type Iglycolysisheat stressHepaRGhepatotoxicityhexosamineimflammationin vitroinflammationlipid homeostasislipid metabolismlipidomicsliquid chromatographyliquid chromatography-mass spectrometryliverLiver biopsyliver functionmass spectrometrymetabolic pathwaymetabolic profilemetabolic stressmetabolomicsMetabolomicsmetabolomics quantitative profilingmultivariate statistical analysisNAFLNAFLDNASHnicotinamidenon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisnonalcoholic fatty livernonalcoholic fatty liver diseasenonalcoholic steatohepatitisnuclear magnetic resonance spectroscopyoxidative stresspentose phosphate pathwaypremalignantprimary mouse hepatocytesProteomicsrat plasmareference toxicantssodium saccharinstandard operating proceduressteatosistandem mass spectrometrytissuetranscription factorsTranscriptomicsurineMedicine and NursingWahli Walteredt1328658Guillou HervéedtWahli WalterothGuillou HervéothBOOK9910557148103321Metabolism and Metabolomics of Liver in Health and Disease3038789UNINA