03817nam 2201117z- 450 991055713490332120210501(CKB)5400000000040704(oapen)https://directory.doabooks.org/handle/20.500.12854/68453(oapen)doab68453(EXLCZ)99540000000004070420202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierOxidative Stress in Diabetic RetinopathyBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (322 p.)3-0365-0448-6 3-0365-0449-4 The combination of an increasing prevalence of diabetes and the aging of populations enables the appearance of a greater number of associated complications such as diabetic retinopathy. Diabetic retinopathy is the leading cause of preventable vision loss in working-age adults. The objective of this Special Issue is to highlight the existing evidence regarding the relationship between oxidative stress and low-grade chronic inflammation induced by hyperglycemia with the development and progression of diabetic retinopathy, with an emphasis on the importance of early diagnosis and the use of antioxidant and anti-inflammatory approaches to prevent or delay the harmful effects of diabetes on retinal tissue.Medicinebicsscagingangiogenesisantioxidantantioxidantsapoptosisaqueous humorascorbic acidastaxanthinbiomarkersbiomarkers of diabetic retinopathyblood-retinal barriercarotenoidCinnamomi RamulusCPA4-1cyclooxygenaseCytochrome P450db/db micediabetes mellitusdiabetic retinopathydiabetic retinopathy (DR)docosahexaenoic acid (DHA)eicosanoidseicosapentaenoic acid (EPA)epiretinal membraneextracellular vesiclesfenofibratefree radicalsGLP-1glycationglyoxalaseHDAC6high-mobility group box 1 (HMGB1)human retinahyperglycemiainflammationinflammatory pathwaysinternal limiting membranelipoxygenasemacular holemetabolic memorymiRNAmitochondrian/anovel therapiesNrf2occludinoxidative stressPaeoniae Radixphotoreceptorphotoreceptor cellsPI3Kproliferative diabetic retinopathyreactive oxygen speciesredoxretinal diseaseretinal endothelial cell senescenceretinal endothelial cellsretinal pigment epitheliumsuperoxide dismutasetear filmthioredoxintubastatin Avitamin Dvitreoretinal surgeryvitreous humorMedicineOrtega Ángel Luisedt1294143Ortega Ángel LuisothBOOK9910557134903321Oxidative Stress in Diabetic Retinopathy3022924UNINA