03780nam 2201093z- 450 991055713490332120231214132836.0(CKB)5400000000040704(oapen)https://directory.doabooks.org/handle/20.500.12854/68453(EXLCZ)99540000000004070420202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierOxidative Stress in Diabetic RetinopathyBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (322 p.)3-0365-0448-6 3-0365-0449-4 The combination of an increasing prevalence of diabetes and the aging of populations enables the appearance of a greater number of associated complications such as diabetic retinopathy. Diabetic retinopathy is the leading cause of preventable vision loss in working-age adults. The objective of this Special Issue is to highlight the existing evidence regarding the relationship between oxidative stress and low-grade chronic inflammation induced by hyperglycemia with the development and progression of diabetic retinopathy, with an emphasis on the importance of early diagnosis and the use of antioxidant and anti-inflammatory approaches to prevent or delay the harmful effects of diabetes on retinal tissue.Medicinebicssceicosanoidsoxidative stressdiabetic retinopathycyclooxygenaselipoxygenaseCytochrome P450HDAC6tubastatin Aretinal endothelial cellsretinal endothelial cell senescencedb/db miceCinnamomi RamulusPaeoniae RadixCPA4-1blood-retinal barrieroccludinhuman retinaepiretinal membraneinternal limiting membranevitreoretinal surgerymacular holeproliferative diabetic retinopathyantioxidantsdiabetes mellitusfree radicalshigh-mobility group box 1 (HMGB1)inflammatory pathwaysnovel therapiesdiabetic retinopathy (DR)inflammationangiogenesisextracellular vesiclesmiRNAbiomarkersapoptosisfenofibratethioredoxinhyperglycemiaastaxanthincarotenoidreactive oxygen speciesphotoreceptor cellsPI3KNrf2eicosapentaenoic acid (EPA)docosahexaenoic acid (DHA)retinal pigment epitheliumantioxidantascorbic acidretinal diseasevitamin DGLP-1superoxide dismutasebiomarkers of diabetic retinopathymetabolic memorytear filmaqueous humorvitreous humormitochondriaredoxphotoreceptorglycationagingglyoxalaseMedicineOrtega Ángel Luisedt1294143Ortega Ángel LuisothBOOK9910557134903321Oxidative Stress in Diabetic Retinopathy3022924UNINA