04886nam 2201585z- 450 991055712940332120231214133304.0(CKB)5400000000040760(oapen)https://directory.doabooks.org/handle/20.500.12854/68362(EXLCZ)99540000000004076020202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNovel Biomarkers in Alzheimer's DiseaseBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (442 p.)3-03943-903-0 3-03943-904-9 Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.MedicinebicsscflotillinAlzheimer's diseasebiomarkerexosomesbeta-amyloidTauagingbiomarkerscytokinescognitive declinemetabolomicsneuroinflammationmultivariate analysisphysical performanceperson-tailoredPET/CT(18F)FDGneuropsychological assessmentAPP mutationsAPOE allelesPSEN1PSEN2germline mutationslate onset ADearly onset ADfamilial ADgenetics of ADmitochondrial spare respiratory capacitymitochondrialmembrane potentialglycolytic reservesemantic memoryphonemic fluencyepisodic memoryneuropsychologyneuroimagingAlzheimer's diseasemild cognitive impairmentEEGTMSobesitydiabetesinflammationAmyloid Betamitochondrial dysfunctionnutritionomega-3 fatty acidsantioxidantcarotenoidsvitamin Ecognitionolder adultsageingsubjective cognitive declineclock genesClockApoEcardiovascular risk factorsAlzheimer diseasesemantic primingamyloid betacerebrospinal fluidamyloid beta peptidetotal tauphosphorylated taudiagnosisdrug developmentclinical trialsdiagnostic researchvirusbacteriadementiabloodbehavioral and psychological symptoms of dementia (BPSD)Alzheimer's disease (AD)neuropsychiatry inventory scale (NPI)endophenotypesCART analysisMTHFRAPOECOMTgenetic variantsearly diagnosisbiofluidsamyloid cascade hypothesisglucose metabolismadipose tissue dysfunctionenergetic metabolismlysosomes dysfunctionType-3-Diabetesneurodegenerationamyloidtausoluble TREM2NfLMultiplexSiMoAdiagnosticsmessenger RNAmicroRNAneurotropic microbesprecision medicineprognosticssynaptic biomarkersneurofilament light chainMedicineVilla Chiaraedt1280948Villa ChiaraothBOOK9910557129403321Novel Biomarkers in Alzheimer's Disease3031265UNINA