04945nam 2201609z- 450 991055712940332120210501(CKB)5400000000040760(oapen)https://directory.doabooks.org/handle/20.500.12854/68362(oapen)doab68362(EXLCZ)99540000000004076020202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNovel Biomarkers in Alzheimer's DiseaseBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (442 p.)3-03943-903-0 3-03943-904-9 Alzheimer's disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.Medicine and Nursingbicssc(18F)FDGadipose tissue dysfunctionageingagingAlzheimer diseaseAlzheimer's diseaseAlzheimer's diseaseAlzheimer's disease (AD)amyloidamyloid betaAmyloid Betaamyloid beta peptideamyloid cascade hypothesisantioxidantApoEAPOEAPOE allelesAPP mutationsbacteriabehavioral and psychological symptoms of dementia (BPSD)beta-amyloidbiofluidsbiomarkerbiomarkersbloodcardiovascular risk factorscarotenoidsCART analysiscerebrospinal fluidclinical trialsClockclock genescognitioncognitive declineCOMTcytokinesdementiadiabetesdiagnosisdiagnostic researchdiagnosticsdrug developmentearly diagnosisearly onset ADEEGendophenotypesenergetic metabolismepisodic memoryexosomesfamilial ADflotillingenetic variantsgenetics of ADgermline mutationsglucose metabolismglycolytic reserveinflammationlate onset ADlysosomes dysfunctionmembrane potentialmessenger RNAmetabolomicsmicroRNAmild cognitive impairmentmitochondrialmitochondrial dysfunctionmitochondrial spare respiratory capacityMTHFRMultiplexmultivariate analysisn/aneurodegenerationneurofilament light chainneuroimagingneuroinflammationneuropsychiatry inventory scale (NPI)neuropsychological assessmentneuropsychologyneurotropic microbesNfLnutritionobesityolder adultsomega-3 fatty acidsperson-tailoredPET/CTphonemic fluencyphosphorylated tauphysical performanceprecision medicineprognosticsPSEN1PSEN2semantic memorysemantic primingSiMoAsoluble TREM2subjective cognitive declinesynaptic biomarkerstauTauTMStotal tauType-3-Diabetesvirusvitamin EMedicine and NursingVilla Chiaraedt1280948Villa ChiaraothBOOK9910557129403321Novel Biomarkers in Alzheimer's Disease3031265UNINA