04612nam 22007091 450 991046318220332120211005194724.01-78225-010-71-4725-6622-X1-78225-009-310.5040/9781472566225(CKB)2670000000355651(EBL)1137419(OCoLC)842883507(SSID)ssj0000873448(PQKBManifestationID)11524340(PQKBTitleCode)TC0000873448(PQKBWorkID)10877685(PQKB)11121022(MiAaPQ)EBC1772799(MiAaPQ)EBC1137419(Au-PeEL)EBL1772799(CaPaEBR)ebr10694986(CaONFJC)MIL490486(OCoLC)893332319(OCoLC)842936626(UtOrBLW)bpp09256317(MiAaPQ)EBC6165119(Au-PeEL)EBL1137419(EXLCZ)99267000000035565120140929d2012 uy 0engur|n|---|||||txtccrEmpowerment and disempowerment of the European citizen /edited by Michael Dougan, Niamh Nic Shuibhne and Eleanor Spaventa1st ed.Oxford, United Kingdom :Hart Publishing,2012.1 online resource (331 p.)Modern studies in European law ; v. 35Description based upon print version of record.1-84946-235-6 Includes bibliographical references and index.The transnational character of Union citizenship -- Anastasia Iliopoulou Penot -- The past, present and future of the purely internal rule in EU law -- Siofra O'Leary -- A stage, a spotlight and an unwritten script : frontier zones and intersectional citizens -- Charlotte O'Brien -- The role of judge-made law and EU supranational government : a bumpy road from secrecy to translucence -- Deirdre Curtin -- Democratic adjudication in Europe : how can the European Court of Justice be responsive to the citizens? -- Bruno de Witte -- A very cosmopolitan citizenship : but who pays the price? -- Michelle Everson -- Europe in times of economic crisis : bringing Europe's citizens closer to one another? -- Fabian Amtenbrink -- Can the EU deliver on citizen expectations in the fight against climate change? -- Joanne Scott -- Is the citizen driving the EU's criminal law agenda? -- Ester Herlin-Karnell -- For better, for worse : the relationship between EU citizenship and the development of cross-border family law -- Helen Stalford -- How could the new Article 11 TEU contribute to reduce the EU's democratic malaise? -- Luis Bouza Garcia -- The European Citizens' Initiative : a new institution for empowering Europe's citizens? -- Graham Smith -- The legislative initiative : a comparative analysis of the domestic experiences in EU countries -- Matt Qvortrup.This collection of essays engages with a central theme in scholarship on EU citizenship - the emancipation of certain citizens, the alienation of others - and seeks to expand its horizons to interrogate whether similar debates and trends can be identified in other fields of European integration. The focus of the book is distinctly citizen focused. It delivers the potential for the opening out of analysis of the implications of European citizenship beyond the parameters of Articles 18-25 TFEU and beyond the disciplinary confines of legal analysis alone. The book construes 'EU citizenship' in its broadest sense, and explores the extent to which the European citizen is, or indeed is not, genuinely at the heart of EU law and policy-making. Within the broader theme of empowerment and disempowerment, the contributors reflect on a range of cross-cutting themes; for example, the extent to which channels of citizen participation (can) inform EU policy-making in a 'bottom-up' sense; or whether the EU is a catalyst for the construction of new spaces and new identitiesModern studies in European law ;v. 35.CitizenshipEuropean Union countriesCitizenship & nationality lawElectronic books.Citizenship323.042094Dougan MichaelPh. D.,Nic Shuibhne NiamhSpaventa Eleanor1972-UtOrBLWUtOrBLWUkLoBPBOOK9910463182203321Empowerment and disempowerment of the European citizen2480135UNINA07257nam 2202173z- 450 991055712910332120210501(CKB)5400000000040763(oapen)https://directory.doabooks.org/handle/20.500.12854/68429(oapen)doab68429(oapen)68429(EXLCZ)99540000000004076320202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAnticancer AgentsDesign, Synthesis and EvaluationBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (606 p.)3-0365-0140-1 3-0365-0141-X This book is a printed edition of the Special Issue entitled "Anticancer Agents: Design, Synthesis and Evaluation" that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.Anticancer AgentsMedicine and Nursingbicssc1,2,3-triazole2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide3,6-dibromocarbazole4-(pyridin-4-yloxy)benzamide5-bromoindole5-fluorouracilABCB1 (P-glycoprotein)actinADMEalleneamides/estersandrogen receptoranti-cancer activityanti-neuroinflammationanti-ovarian canceranti-tumoranticanceranticancer activityanticancer agentanticancer agentsanticancer compoundsantimitotic agentsantioxidant activityantiproliferative activityantiproliferative agentantitumorantitumor activityapalutamideapoptosisaromatasebenzimidazolebenzofuran-pyrazolebenzofuransbeta-lapachonebivalencybreast cancerc-Metcarbazolecell cyclechemical synthesischemoresistancechrysin analoguescolchiceinecolchicine amidecolchicine analogscolchicine sulfonamidecolon cancercomputational dockingcoumarincrystal structurecyanopyridonecytotoxic activitycytotoxic propertiescytotoxicitydarolutamideDFT studydihydroartemisinindihydropyranoindoledockingdocking studiesdrug discoverydrug resistanceE-stereoselectiveenzalutamideenzyme inhibitionestrone derivativesflavonoidflavonoidsgemcitabineHDAC inhibitorsHeLaHepG2hydrateshydrazineIGF-1RIL-12immune modulationindoleamine 2,3-dioxygenaseinflammationinhibitorK562kinase inhibitorMCF-7MDM2-p53 interactionmigrationmimeticsmolecular simulationMOLT-4multidrug resistance (MDR) reversalN-substituted pyrazolinenanoparticlesnatural productneuroblastomaNIH3T3o-nitro-benzylorganosilicon compoundsortho-quinonesovarian cancerovercoming drug resistanceP-glycoproteinP-MAPAPARP inhibitorPARP-1 inhibitionphenylpyrazolopyrimidinephotoactivatable protecting groupsPI3KsPI3Kα inhibitorPI3Kδ inhibitorspolyvalencyprodrugprostate cancerPROTACsprotein degradationprotein kinaseprotein-protein interactionsPyrazolepyrazolopyridinepyridotriazinequinazolin-4(3H)-onequinazolin-4(3H)-thioneregioselectivesalinomycinSchiff baseSILA-409 (Alis-409)SILA-421 (Alis-421)Srcsubstituted pyridinesynergysynthesisTalazoparibtanshione IIAtaxoidsthiazolidinoneThienopyrimidinethienopyrimidinonethiocolchicinethiopenethioxotriazopyridineTLR signalingtopoisomerase II inhibitortriazolothiadiazinetriple-negative breast cancertryptophan metabolismtubulin inhibitorstumor specificityureavirtual screeningxanthonesyeast-based assayszampanolideβIII-tubulinMedicine and NursingChen Qiao-Hongedt1313308Chen Qiao-HongothBOOK9910557129103321Anticancer Agents3031264UNINA