04024nam 2200853z- 450 991055712430332120210501(CKB)5400000000040811(oapen)https://directory.doabooks.org/handle/20.500.12854/68356(oapen)doab68356(EXLCZ)99540000000004081120202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Effect of Calorie Restriction and Intermittent Fasting on Health and DiseaseBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (186 p.)3-03943-837-9 3-03943-838-7 Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer's disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, "The effects of calorie restriction and intermittent fasting on health and disease", focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.Biology, life sciencesbicsscCultural studies: food and societybicsscResearch and information: generalbicsscadipocyteadiponectinagingautophagybody mass reductioncalcium transient proteinscaloric restrictioncalorie restrictioncalorie restriction (CR)calorie restriction dietCR mimeticfastingfat massfatty acid biosynthesisFoxO transcription factorheart impairmentIGF-1insulininsulin secretionintermittent fastingL-type calcium channelleptinlifespanlongevitymalnutritionmimeticsmitochondrial biogenesisn/aneuropeptide Ypancreatic isletpapillary muscle assayphotoagingpleiotropy of CR genessenescence-associated secretory phenotypesenoinflammationSERCA2asirtuinskin agingskin appendagesBiology, life sciencesCultural studies: food and societyResearch and information: generalChung Hae-Youngedt1302967Chung Hae-YoungothBOOK9910557124303321The Effect of Calorie Restriction and Intermittent Fasting on Health and Disease3026785UNINA