05670nam 2201585z- 450 991055712400332120210501(CKB)5400000000040814(oapen)https://directory.doabooks.org/handle/20.500.12854/68416(oapen)doab68416(EXLCZ)99540000000004081420202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPLGA Based Drug Carrier and Pharmaceutical ApplicationsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (328 p.)3-0365-0220-3 3-0365-0221-1 Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.Medicinebicssc17-βestradiol releaseactivationaggregationalginatebindingbiodegradable polymersBMP-2BMP-2-microspheresbone regenerationcancercellular uptakeCHO-K1 cellscisplatincolorectal cancercontrolled drug releasecontrolled releasecore-shell nanoparticlesdexamethasonedouble emulsion approachdrug deliverydrug delivery systemsdrug releaseelectron microscopyelectroporationexperimental designfolic acidformulation developmentfractional factorial designgadoliniumgastrointestinal tractglioblastoma multiformeHuntington's diseasehydrogelhydrogel systemhydroxy-stearic acidin vivo imagingintra-abdominal anti-adhesion barrierintra-articular injectionjoint retentionLEDlocal deliverymagnetic resonance imagingmagnetic targetingmesenchymal stromal cellsmicrocapsulesmicrocarriersmicrocrystalmicrofluidicsmicroparticlesmicrospheremicrospheresmolecular mobilitymultimodal imagingn/anano-CTnanomedicinenanoparticlesnanoscaled drug deliveryNSAIDsO6-methylguanine DNA methyltransferase (MGMT) proteinoleogelsophthalmic drug deliveryosteoporosisoxaliplatinpaclitaxelphotoluminescencePLAplateletPLGAPLGA microspherePLGA nanocapsulesPLGA nanoparticlesPLGA-NPsPLGA-PEGPluronic F68poly-lactide-co-glycolidepolylactic acidpolymeric filmpolymeric nanocarrierreactive oxygen speciesrisperidoneserum stabilitysiliconsiRNASKOV-3 cellssmart nanocarrierssorafenibspray-drying techniquesystemic exposureterahertz spectroscopytheranostic cargotheranostic nanoparticlestheranosticsthree-dimensional X-ray imagingtissue engineeringtocopheroltopical drug deliverytriamcinolone acetonidetrolamine salicylateuptakeverteporfinvitamin EMedicinePereira Maria Carmoedt1318423Loureiro JoanaedtPereira Maria CarmoothLoureiro JoanaothBOOK9910557124003321PLGA Based Drug Carrier and Pharmaceutical Applications3033226UNINA