05633nam 2201561z- 450 991055712400332120231214133254.0(CKB)5400000000040814(oapen)https://directory.doabooks.org/handle/20.500.12854/68416(EXLCZ)99540000000004081420202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPLGA Based Drug Carrier and Pharmaceutical ApplicationsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (328 p.)3-0365-0220-3 3-0365-0221-1 Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.MedicinebicsscPLGAnanoscaled drug deliveryLEDcancerserum stabilityreactive oxygen speciescellular uptaketerahertz spectroscopymicrospheresdrug deliveryformulation developmentmolecular mobilityvitamin EtocopherolPLAcore-shell nanoparticlescontrolled drug releaseBMP-2PLGA nanoparticlesPluronic F68oxaliplatinhydrogelintra-abdominal anti-adhesion barriercolorectal cancerexperimental designfractional factorial designO6-methylguanine DNA methyltransferase (MGMT) proteinglioblastoma multiformesmart nanocarriersfolic acidverteporfincisplatinSKOV-3 cellsCHO-K1 cellselectroporationtheranostic cargodouble emulsion approachNSAIDspolymeric filmtopical drug deliverytrolamine salicylatetriamcinolone acetonidemicrocrystalPLGA microspherelocal deliveryspray-drying techniqueintra-articular injectionjoint retentionsystemic exposuregadoliniumdrug releasepolymeric nanocarriersorafenibtheranostic nanoparticlesPLGA-PEGnanoparticlesplateletactivationaggregationbindinguptaketissue engineeringHuntington's diseasesiRNAmicrocarriersmesenchymal stromal cellsdrug delivery systemsmicrofluidicsmicroparticlesBMP-2-microsphereshydrogel system17-βestradiol releasebone regenerationosteoporosispoly-lactide-co-glycolidepolylactic acidalginateophthalmic drug deliverydexamethasonePLGA-NPsnanomedicinegastrointestinal tractpaclitaxelin vivo imagingcontrolled releaserisperidonemicrocapsulesoleogelselectron microscopythree-dimensional X-ray imagingnano-CTbiodegradable polymershydroxy-stearic acidPLGA nanocapsulesmagnetic resonance imagingphotoluminescencemagnetic targetingmultimodal imagingtheranosticssiliconmicrosphereMedicinePereira Maria Carmoedt1318423Loureiro JoanaedtPereira Maria CarmoothLoureiro JoanaothBOOK9910557124003321PLGA Based Drug Carrier and Pharmaceutical Applications3033226UNINA