03308nam 2200769z- 450 991055712360332120210501(CKB)5400000000040818(oapen)https://directory.doabooks.org/handle/20.500.12854/68419(oapen)doab68419(EXLCZ)99540000000004081820202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierToxins and Cancer TherapyBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (104 p.)3-0365-0190-8 3-0365-0191-6 Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer will only rise in the coming decades, necessitating continued improvement in our cancer therapies. Remarkably, in the late 1800s, bone surgeon William Coley serendipitously discovered that bacteria could be administered to patients as an effective (and sometimes toxic) form of cancer therapy known as "Coley's Toxins". His discoveries unknowingly led to two fields of cancer therapy that have been in development for decades and are now leading to significant improvements in therapy for cancer patients: immune-based and toxin-based therapies for cancer. Articles included here discuss the discoveries that emerged from Coley's Toxins that enable us to harness the immune system and microbial toxins to combat cancers, as oncology shifts from a field dominated by chemotherapy for most of the 20th century to biologic therapies that will dominate the 21st century.Medicine and Nursingbicsscadoptive cell therapyapoptosisautophagybotulinum neurotoxinbotulinum toxinBurkitt lymphomacancercancer cellsColey's Toxinscolorectal cancercytokine therapycytotoxic necrotizing factor type 1drug discoveryER stressfurinGb3/CD77glioblastomagustatory hyperhidrosisimmune checkpoint inhibitorsimmunotherapyimmunotoxinintracellular traffickingn/aneuropathic painparotid fistulaparotid glandpost-surgical painprotein purificationrecombinant protein productionribotoxinRNase T1shiga toxinssialocelesubmaxillary glandvaccineα-sarcinMedicine and NursingSnook Adam Eedt1318422Snook Adam EothBOOK9910557123603321Toxins and Cancer Therapy3033225UNINA