03324 am 2200757 n 450 991049574950332120240104030507.02-7574-1842-410.4000/books.septentrion.19744(CKB)4100000003667387(FrMaCLE)OB-septentrion-19744(PPN)225783916(EXLCZ)99410000000366738720180328j|||||||| ||| 0freuu||||||m||||Questionner l'espaceLes méthodes de recherche en didactiques (4)Cora Cohen-Azria, Marie-Pierre Chopin, Denise Orange-RavacholVilleneuve d'AscqPresses universitaires du Septentrion20181 online resource (266 p.) 2-7574-1158-6 Questionner l'espace s'inscrit dans la continuité des réflexions menées autour des méthodes de recherche en didactiques et fait suite aux trois premiers ouvrages : outre le volume premier, le volume Questions de temporalité et le troisième Questionner l’implicite. En traitant ici de la perception de l’espace et des enjeux de son questionnement dans les travaux en didactiques, ce dernier volume ouvre un chantier théorique et méthodologique vaste sur une dimension peu problématisée et néanmoins fondamentale dans les recherches sur les constructions des savoirs.EducationResearchMethodologyCongressesEducationResearchMethodologyArseneau Rosianne1458034Audigier François1283595Biagioli Nicole1290563Boyer Catherine1458035Chopin Marie-Pierre1306204Cohen-Azria Cora1290564Dias-Chiaruttini Ana1327348Dufays Jean-Louis779994Foucambert Denis1458036Galluzzo-Dafflon Rosine1310048Georget Jean-Philippe1456076Glaudel Anne1458037Guern Anne-Laure Le1458038Helloco-Moy Gaïta Le1458039Jaubert Martine1292672Jovenet Anne-Marie1290568Lahanier-Reuter Dominique1290569Lebeaume Joël1291490Lefrançois Pascale1301783Mangiante-Orsola Christine1458040Martinand Jean-Louis1290575Mathé Anne-Cécile1458041Nicolas Laura1458042Orange Christian1124646Pelay Nicolas1458043Perrin-Glorian Marie-Jeanne1290577Philippot Thierry1296782Quilio Serge1458044Ravachol Denise Orange1458045Rebière Maryse1292674Sabra Hussein1458046Thémines Jean-François1080302Torterat Frédéric1458047Zaid Abdelkarim1291499Cohen-Azria Cora1290564Chopin Marie-Pierre1306204Orange-Ravachol Denise1458048Université de Lille III,FR-FrMaCLEBOOK9910495749503321Questionner l'espace3658165UNINA05457nam 2201501z- 450 991055711480332120210501(CKB)5400000000040898(oapen)https://directory.doabooks.org/handle/20.500.12854/69028(oapen)doab69028(EXLCZ)99540000000004089820202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierActinomycetesThe Antibiotics ProducersBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (362 p.)3-03936-910-5 3-03936-911-3 Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetesActinomycetesBiology, life sciencesbicsscResearch & information: generalbicssc(p)ppGppA40926ActinoallomurusactinobacteriaActinobacteriaactinomycetesacyltransferasesAmycolatopsisantibioticantibioticsantibiotics polyethersaromatic polyketidebenz[a]naphthacene quinonebiogeographybiological activitybiosynthesisbiosynthetic gene clusterCave microbiologychemical ecologycomparative genomicsculture-based approachescyclasesdalbavancindbv clusterdereplicationdifferentiationdiversificationdrug discoveryelicitorsengineeringextended polyketide chainFK506genome mininggeomicrobiologyglycopeptide antibioticsIllumina sequencingLALliquid culturesLuxR sololysolipinmetabolomicsmetagenomicsmicrobiome diversityminimal PKS IImorphologyn/anatural productsnew bioactive compoundsnovel compoundsomicspentacyclic angular polyphenolphysical and chemical propertiesphysicochemical screeningpolyadenylationpolyketide synthasespolyketidespolynucleotide phosphorylasepromoterrare Actinobacteriarare actinomycetesregulationregulatory genesresistanceribonucleaserishirilideRNA decayscreeningsecondary metabolismsecondary metabolitesecondary metabolite biosynthetic gene clusterssecondary metabolitessecretion pathwayssecretory proteinssiderophoresignal peptidesSMGCspecialized metabolitesstrainstreptomycesStreptomycesStreptomyces lividansStreptomyces tsukubaensisStrRstructural diversitysymbiosistacrolimusteicoplanintridecaketideunculturabilityvan resistance genesβ-lactamaseβ-lactamase inhibitorBiology, life sciencesResearch & information: generalStegmann Eviedt1294099Mast YvonneedtStegmann EviothMast YvonneothBOOK9910557114803321Actinomycetes3022869UNINA