05216nam 2201285z- 450 991055711330332120231214133630.0(CKB)5400000000040913(oapen)https://directory.doabooks.org/handle/20.500.12854/69246(EXLCZ)99540000000004091320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdipose-Derived Stromal/Stem CellsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (286 p.)3-03943-282-6 3-03943-283-4 Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cells. Donor-specific differences in ASC isolations and the lack of culture standardization hinder the comparison of results from different studies. Nevertheless, ASCs are already being used in different in vivo models and clinical trials to investigate their ability to improve tissue and organ regeneration. Many questions concerning their counterparts and biology in situ, their differentiation potential in vitro and in vivo, and the mechanisms of regeneration (paracrine effects, including regeneration-promoting factors and extracellular vesicles, differentiation, and immunomodulation) are not completely understood or remain unanswered. This Special Issue covers research articles investigating various adipose tissues as a source for ASC isolation, specific cultures methods to enhance proliferation or viability, and the differentiation capacity. Furthermore, other studies highlight aspects of various diseases, the immunosuppressive potential of ASCs and their derivates, or the in vivo tracking of transplanted ASCs. This edition is complemented by a review that summarizes the current knowledge of spheroid culture system methods and applications for mesenchymal stem cells.Medicinebicssclipomasadipose tissuestem cellsadipogenesisosteogenesismesenchymal stem cellsT-cellsconditioned mediumextracellular vesiclesTLRINF-γadipose-derived stromal cellsequine metabolic syndromemetforminadipose-derived stem cellsadipocytesdifferentiationcollagen Iadiponectinintegrinsdiscoidin domain-containing receptorageingsubcutaneous fatadipose tissue-derived mesenchymal stromal/stem cells (ASCs)cell differentiationvolatile organic compoundsmetabolic monitoringadipose-derived stromal/stem cellschondrogenesiscolony forming unit-fibroblastfetal bovine serumhuman platelet lysatemesenchymal stem cellregenerative medicinehuman adipose-derived stem cellsstem cell proliferationsignaling pathwayadipose-derived mesenchymal stem cellsmigrationsecretionprimary ciliumsonic hedgehog signalingmesenchymal stromal/stem cellsperirenalfatcharacterizationstimulationlipopolysaccharidecytokinescytomegalovirusangiogenesisadipose derived mesenchymal cellsHistogel3D cell culturespheroid culturebiomaterialsphenotypesecretory potentialankylosing spondylitissystemic lupus erythematosussystemic sclerosismesenchymal stromal cellsbreast cancertumor microenvironmentperineural invasionadipose derived stem cellsvalproic acidprotein interactionsMAPK pathwayJAK/STAT pathwaymesenchymal stromal celltissue of originprolonged cultureepigenetic memorytrackingbio imagingbioluminescenceqRT-PCRAtaxia telangiectasiaAtmMedicineBaer Patrick Cedt1293413Baer Patrick CothBOOK9910557113303321Adipose-Derived Stromal3022595UNINA