05277nam 2201309z- 450 991055711330332120210501(CKB)5400000000040913(oapen)https://directory.doabooks.org/handle/20.500.12854/69246(oapen)doab69246(EXLCZ)99540000000004091320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdipose-Derived Stromal/Stem CellsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (286 p.)3-03943-282-6 3-03943-283-4 Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cells. Donor-specific differences in ASC isolations and the lack of culture standardization hinder the comparison of results from different studies. Nevertheless, ASCs are already being used in different in vivo models and clinical trials to investigate their ability to improve tissue and organ regeneration. Many questions concerning their counterparts and biology in situ, their differentiation potential in vitro and in vivo, and the mechanisms of regeneration (paracrine effects, including regeneration-promoting factors and extracellular vesicles, differentiation, and immunomodulation) are not completely understood or remain unanswered. This Special Issue covers research articles investigating various adipose tissues as a source for ASC isolation, specific cultures methods to enhance proliferation or viability, and the differentiation capacity. Furthermore, other studies highlight aspects of various diseases, the immunosuppressive potential of ASCs and their derivates, or the in vivo tracking of transplanted ASCs. This edition is complemented by a review that summarizes the current knowledge of spheroid culture system methods and applications for mesenchymal stem cells.Medicine and Nursingbicssc3D cell cultureadipocytesadipogenesisadiponectinadipose derived mesenchymal cellsadipose derived stem cellsadipose tissueadipose tissue-derived mesenchymal stromal/stem cells (ASCs)adipose-derived mesenchymal stem cellsadipose-derived stem cellsadipose-derived stromal cellsadipose-derived stromal/stem cellsageingangiogenesisankylosing spondylitisAtaxia telangiectasiaAtmbio imagingbioluminescencebiomaterialsbreast cancercell differentiationcharacterizationchondrogenesiscollagen Icolony forming unit-fibroblastconditioned mediumcytokinescytomegalovirusdifferentiationdiscoidin domain-containing receptorepigenetic memoryequine metabolic syndromeextracellular vesiclesfatfetal bovine serumHistogelhuman adipose-derived stem cellshuman platelet lysateINF-γintegrinsJAK/STAT pathwaylipomaslipopolysaccharideMAPK pathwaymesenchymal stem cellmesenchymal stem cellsmesenchymal stromal cellmesenchymal stromal cellsmesenchymal stromal/stem cellsmetabolic monitoringmetforminmigrationn/aosteogenesisperineural invasionperirenalphenotypeprimary ciliumprolonged cultureprotein interactionsqRT-PCRregenerative medicinesecretionsecretory potentialsignaling pathwaysonic hedgehog signalingspheroid culturestem cell proliferationstem cellsstimulationsubcutaneous fatsystemic lupus erythematosussystemic sclerosisT-cellstissue of originTLRtrackingtumor microenvironmentvalproic acidvolatile organic compoundsMedicine and NursingBaer Patrick Cedt1293413Baer Patrick CothBOOK9910557113303321Adipose-Derived Stromal3022595UNINA