04237nam 2201069z- 450 991055711200332120210501(CKB)5400000000040926(oapen)https://directory.doabooks.org/handle/20.500.12854/69328(oapen)doab69328(EXLCZ)99540000000004092620202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Aspects of Cancer Stem Cell BiologyImplications for Innovative TherapiesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (208 p.)3-03943-406-3 3-03943-407-1 The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic "state" of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on "New aspects of cancer stem cell biology: implications for innovative therapies" aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.New Aspects of Cancer Stem Cell Biology Biology, life sciencesbicsscResearch & information: generalbicsscALDH1ATAC-seqB4GALT1bevacizumabbowel cancerbreast cancerCadherin 11cancer stem cellcancer stem cellscancer therapycell adhesion moleculechemo-resistancechemoresistancechemotherapy resistancecoloncolorectalCSCsdasatinibearly breast cancerEC-8042epithelial-mesenchymal transitionexosomesgenetic heterogeneitygenome-wideHDAC inhibitorshead and neck squamous cell carcinomaimmunohistochemistryL1CAMlipidLUADlung cancermetabolismneoadjuvant chemotherapyNSCLCoral cancer riskoral epithelial dysplasiaoral squamous cell carcinomaorganoidovarian cancerOvarian cancerRNA-seqsaracatinibSNP arraysolid cancerSOX2SRCstem celltherapeutic resistancetherapy resistanceTNBCtranscriptometumor progressiontumoroidWnt signalingWNT signalingβ-cateninBiology, life sciencesResearch & information: generalCavallaro Ugoedt406773Giordano MarcoedtCavallaro UgoothGiordano MarcoothBOOK9910557112003321New Aspects of Cancer Stem Cell Biology3021982UNINA