04228nam 2201057z- 450 991055711200332120231214132827.0(CKB)5400000000040926(oapen)https://directory.doabooks.org/handle/20.500.12854/69328(EXLCZ)99540000000004092620202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Aspects of Cancer Stem Cell BiologyImplications for Innovative TherapiesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (208 p.)3-03943-406-3 3-03943-407-1 The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.New Aspects of Cancer Stem Cell Biology Research & information: generalbicsscBiology, life sciencesbicsscCadherin 11WNT signalingβ-catenincancer stem cellsTNBCearly breast cancerbevacizumabneoadjuvant chemotherapyALDH1solid cancerchemo-resistanceHDAC inhibitorshead and neck squamous cell carcinomaSRCdasatinibsaracatinibEC-8042Ovarian cancerWnt signalingtumor progressiontherapy resistanceexosomesoral cancer riskoral epithelial dysplasiaSOX2immunohistochemistryoral squamous cell carcinomagenome-widetranscriptomelung cancerATAC-seqRNA-seqCSCsNSCLCB4GALT1LUADbreast cancerlipidmetabolismtherapeutic resistancebowel cancerorganoidtumoroidcolorectalcolonstem cellchemotherapy resistanceovarian cancercancer stem cellgenetic heterogeneitySNP arrayL1CAMchemoresistanceepithelial-mesenchymal transitioncancer therapycell adhesion moleculeResearch & information: generalBiology, life sciencesCavallaro Ugoedt406773Giordano MarcoedtCavallaro UgoothGiordano MarcoothBOOK9910557112003321New Aspects of Cancer Stem Cell Biology3021982UNINA