03793nam 2200901z- 450 991055711020332120231214132849.0(CKB)5400000000040945(oapen)https://directory.doabooks.org/handle/20.500.12854/69057(EXLCZ)99540000000004094520202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPeptide Nucleic AcidsApplications in Biomedical SciencesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (154 p.)3-03936-886-9 3-03936-887-7 This book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents.Peptide Nucleic Acids MedicinebicsscRNA structurestrand invasionantisensePNAexon skippingexon inclusionoligonucleotidespeptide nucleic acid (PNA)antibacterialsRNAPNA transportersconjugatesbacterial resistancepeptide nucleic acidstriplexgene editingstructurerecombinationrepairnanoparticlesβ-thalassemiacystic fibrosispeptide nucleic acidtolanesingle nucleotide polymorphisminfluenza virusdrug resistancepeptide nucleic acids (PNAs)single-nucleotide polymorphism (SNP)polymerase chain reaction (PCR)cancer.catalytic hairpin assembly (CHA)strand-displacement reactionl-DNAmicroRNAfluorescencetemplated reactionslight-triggeredelectrochemical biosensorscolorimetric detectionPeptide nucleic acidsPNA-maskingmicroRNAsmiR-145-5pmiRNA targetingdeliveryCFTRMedicineYavin Eylonedt1290288Yavin EylonothBOOK9910557110203321Peptide Nucleic Acids3021451UNINA