03317nam 2200817z- 450 991055710760332120210501(CKB)5400000000040971(oapen)https://directory.doabooks.org/handle/20.500.12854/69424(oapen)doab69424(EXLCZ)99540000000004097120202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierEnzyme Inhibitor from Marine OrganismsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (130 p.)3-03943-783-6 3-03943-784-4 Marine habitats are promising sources to identify novel organisms and compounds. A total of 70% of the planet's surface is covered by ocean, and little is known about the biosphere within these habitats. In the last few years, numerous novel bioactive compounds or secondary metabolites from marine environments have been described. This is, and will be, a promising source of candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques have been introduced to the field and it has become easier to actually (bio-)prospect compounds such as enzyme inhibitors. Those novel compounds then need to be characterized and evaluated in comparison to well-known representatives. This Special Issue focuses on the description of novel enzyme inhibitors of marine origin, including bioprospecting, omic approaches, and structural and mechanistic aspects.Research & information: generalbicsscACE inhibitory peptideacetylcholinesteraseAlzheimer's diseaseasperchalasineBACE1bioactivesdrug developmentenzyme inhibitionfunctional annotationGH109 α-N-acetylgalactosaminidaseGH36 α-galactosidasein silico dockinginactivationinhibitorkinase inhibitorsmacroalgaemarine bacteriamarine fishmarine fungimarine natural productsmarine spongesmolecular dockingmonanchomycalin Bmonanhocidin AMycosphaerella sp.natural productsnormonanhocidin Aoptimizationpentacyclic guanidine alkaloidsphlorotanninsproteasepurificationsecondary metabolitesslow-binding irreversible inhibitorsponge Monanchora pulchrastructural identificationstructure-function relationUlva intestinalisUlva ohnoiα-glucosidaseResearch & information: generalTischler Dirkedt1064503Tischler DirkothBOOK9910557107603321Enzyme Inhibitor from Marine Organisms3036291UNINA