04581nam 2201297z- 450 991055710580332120210501(CKB)5400000000040989(oapen)https://directory.doabooks.org/handle/20.500.12854/68966(oapen)doab68966(EXLCZ)99540000000004098920202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMetastatic Progression and Tumour HeterogeneityBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (312 p.)3-03928-853-9 3-03928-854-7 Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.Medicine and Nursingbicssc3D culturesacidosisADHangiocrine factorbeta-catenin paradoxbiomechanicsbreast cancercarbonic anhydrasecell fatecellular heterogeneitycirculating tumor cellscirculating tumor cells (CTCs)clear cell renal cell carcinomaclonalitycollective and single-cell migrationcolon cancercolorectal cancerCTC-clustersDCISdeficient mismatch repairEMTendometrial carcinomaepigeneticsepithelial mesenchymal plasticityepithelial-to-mesenchymal transitionesophageal squamous cell carcinomaextracellular vesiclesgene expressiongenomicsheterogeneityhybrid E/Mhyperpolarized 13C MRIimmune checkpointsimmune microenvironmentimmunotherapyinterstitial pHintra-tumour heterogeneityintratumor heterogeneitylactic acidmagnetic resonance imagingmammary glandmetaplastic carcinomametastasismetastatic nichemicrosatellite instabilitymiRNA expressionmultisite tumor samplingmutationnatural killer cellsnuclear medicineorganoidspancreatic cancerPETphenotypic plasticityPI3K/AKT pathwayplasticitypositron emission tomographyprecision medicineradiomicsradiopharmaceuticalsreviewsignalingsingle-cell analysissingle-cell RNAseqsubclonal diversitySUVtarget discoverytargeted therapyTP53treatment resistancetumor ecologytumor endothelial celltumor evolutiontumor heterogeneitytumor microenvironmenttumor mutation burdenuterine carcinosarcomaWnt signalingMedicine and NursingHollande Frededt1327820Merino DelphineedtHollande FredothMerino DelphineothBOOK9910557105803321Metastatic Progression and Tumour Heterogeneity3038137UNINA