04540nam 2201285z- 450 991055710580332120231214133422.0(CKB)5400000000040989(oapen)https://directory.doabooks.org/handle/20.500.12854/68966(EXLCZ)99540000000004098920202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMetastatic Progression and Tumour HeterogeneityBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (312 p.)3-03928-853-9 3-03928-854-7 Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.Medicinebicsscclear cell renal cell carcinomatumor evolutiontumor ecologyintratumor heterogeneitymultisite tumor samplingtargeted therapyuterine carcinosarcomaendometrial carcinomametaplastic carcinomaepithelial-to-mesenchymal transitionclonalitymutationTP53PI3K/AKT pathwaygene expressionmiRNA expressiontumor microenvironmentinterstitial pHacidosistumor heterogeneitymagnetic resonance imaginghyperpolarized 13C MRIcarbonic anhydraselactic acidpositron emission tomographyesophageal squamous cell carcinomaprecision medicinenatural killer cellstumor mutation burdenimmunotherapyPETheterogeneityradiomicsradiopharmaceuticalsSUVnuclear medicinecolon cancerWnt signalingphenotypic plasticityEMThybrid E/Mcollective and single-cell migrationbeta-catenin paradoxbreast cancerimmune microenvironmentDCISADHmammary glandcell fate3D culturesorganoidssignalingsingle-cell RNAseqtumor endothelial cellmetastasisangiocrine factormicrosatellite instabilitycolorectal cancerimmune checkpointsdeficient mismatch repairplasticitybiomechanicscirculating tumor cells (CTCs)extracellular vesiclesmetastatic nicheepigeneticsCTC-clusterssingle-cell analysiscellular heterogeneitycirculating tumor cellspancreatic cancerepithelial mesenchymal plasticitytarget discoveryreviewgenomicsintra-tumour heterogeneitysubclonal diversitytreatment resistanceMedicineHollande Frededt1327820Merino DelphineedtHollande FredothMerino DelphineothBOOK9910557105803321Metastatic Progression and Tumour Heterogeneity3038137UNINA