03661nam 2200961z- 450 991055710240332120231214133329.0(CKB)5400000000041023(oapen)https://directory.doabooks.org/handle/20.500.12854/69447(EXLCZ)99540000000004102320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Advances and Applications of OptogeneticsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (164 p.)3-03943-673-2 3-03943-674-0 This book provides an update for the rapidly developing technology known as “optogenetics”, which is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various physiological and biochemical processes within the cell. Two ongoing clinical trials use optogenetic tools for vision restoration, and optogenetic strategies have been suggested as novel therapies for several neurological, psychiatric and cardiac disorders. This Special Issue comprises two reviews and seven experimental papers on different types of light-sensitive modules widely used in optogenetic studies. These papers demonstrate the efficiency and versatility of optogenetics and are expected to be equally relevant for advanced users and beginners considering using optogenetic tools in their research.Research & information: generalbicsscBiology, life sciencesbicsscoptogenetic toolsneurosciencecalcium sensorvoltage sensorneurotransmittersoptogeneticschannelrhodopsinssodiumcalciumDC gateOptogeneticsp53AsLOV2LINuSLEXYMIPPMIChlamydomonas reinhardtiiion channelelectrophysiologymolecular dynamics simulationsmembrane-protein interactionenergy of membrane deformationCTMD method, residual hydrophobic mismatchmicrobial rhodopsinchannelrhodopsinmembrane currenthippocampal neuronslight stimulationchannelrhodopsin-2photoreceptorBLUFmodular domainresonance Ramanflash photolysishybrid QM/MM simulationtwo-photonazobenzenephotoswitchphotoswitchingphotocontrolall-optical electrophysiologymicrobial rhodopsinsion channelsLOV domainsmembrane potentialintracellular traffickingprotein–protein interactionsignalingResearch & information: generalBiology, life sciencesGovorunova Elena Gedt1320353Sineshchekov Oleg AedtGovorunova Elena GothSineshchekov Oleg AothBOOK9910557102403321The Advances and Applications of Optogenetics3034178UNINA