05066nam 2200661 450 991033792960332120210914005128.03-030-16443-8978303016443010.1007/978-3-030-16443-0(CKB)4100000008280427(MiAaPQ)EBC5779981(DE-He213)978-3-030-16443-0(PPN)236522752(EXLCZ)99410000000828042720190521d2019 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierAdvances in Computational Toxicology Methodologies and Applications in Regulatory Science /edited by Huixiao Hong1st ed. 2019.Cham :Springer International Publishing :Imprint: Springer,2019.1 online resource (416 pages)Challenges and Advances in Computational Chemistry and Physics,2542-4491 ;303-030-16442-X Computational Toxicology Promotes Regulatory Science -- Tasks, Major Challenges and Emerging Modelling Methods for Computational Toxicology -- Xenobiotic Metabolism by Cytochrome P450s: Insights Gained from Molecular Simulations -- Applications of Molecular Modeling to Probe the Mechanism of Endocrine Disruptor Action -- Mixture Toxicity -- Towards reproducible in silico practice via OpenTox -- Combining Machine Learning and Multilayer Networks for Toxicity Prediction -- Matrix and tensor factorization for toxicity modelling -- Network-based In Silico Assessment of Drug Cardiotoxicity -- Mode-of-action-guided chemical toxicity prediction: A novel in silico approach for predictive toxicology -- Machine learning methods for toxicity analysis -- Predictive modeling of Tox21 data -- The NTP DrugMatrix Toxicogenomics Database and Analysis Tool -- Applications of Computational Toxicology for Risk Assessment of Food Ingredients and Indirect Food Additives -- In silico prediction of the point of departure (POD) with high throughput data -- The application of topic modeling on drug safety signal detection and analysis -- Molecular dynamics simulations and applications in computational toxicology -- Computational modeling for prediction of drug-induced liver injury in humans -- Genomics in vitro to in vivo extrapolation (GIVIVE) for drug safety evaluation.This book provides a comprehensive review of both traditional and cutting-edge methodologies that are currently used in computational toxicology and specifically features its application in regulatory decision making. The authors from various government agencies such as FDA, NCATS and NIEHS industry, and academic institutes share their real-world experience and discuss most current practices in computational toxicology and potential applications in regulatory science. Among the topics covered are molecular modeling and molecular dynamics simulations, machine learning methods for toxicity analysis, network-based approaches for the assessment of drug toxicity and toxicogenomic analyses. Offering a valuable reference guide to computational toxicology and potential applications in regulatory science, this book will appeal to chemists, toxicologists, drug discovery and development researchers as well as to regulatory scientists, government reviewers and graduate students interested in this field.Challenges and Advances in Computational Chemistry and Physics,2542-4491 ;30ChemoinformaticsPharmacologyBioinformatics Computational biology Chemistry, Physical and theoreticalBioinformaticsComputer Applications in Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C13009Pharmacology/Toxicologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B21007Computer Appl. in Life Scienceshttps://scigraph.springernature.com/ontologies/product-market-codes/L17004Theoretical and Computational Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C25007Computational Biology/Bioinformaticshttps://scigraph.springernature.com/ontologies/product-market-codes/I23050Chemoinformatics.Pharmacology.Bioinformatics .Computational biology .Chemistry, Physical and theoretical.Bioinformatics.Computer Applications in Chemistry.Pharmacology/Toxicology.Computer Appl. in Life Sciences.Theoretical and Computational Chemistry.Computational Biology/Bioinformatics.025.066159Hong Huixiaoedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910337929603321Advances in Computational Toxicology1570969UNINA03623oam 2200961 450 991055423740332120221114044429.01-4798-0158-510.18574/9781479801589(CKB)4100000011716008(MiAaPQ)EBC6452419(DE-B1597)551009(OCoLC)1243310988(DE-B1597)9781479801589(OCoLC)1149331641(MdBmJHUP)musev2_89992(EXLCZ)99410000001171600820210608d2021 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierThe fight for free speech ten cases that define our First Amendment freedoms /Ian RosenbergNew York :New York University Press,[2021]©20211 online resource (310 pages)1-4798-0156-9 1.The Women's March and the marketplace of ideas --2.Take a knee and the Pledge of Allegiance --3.Libel, actual malice, and the civil rights movement --4.Student speech from the Vietnam War to the National School Walkout --5.Stormy Daniels, prior restraints, and the Pentagon Papers --6.Flipping off the president and fuck the draft --7.Samantha Bee, seven dirty words, and indecency --8.Saturday Night Live, Hustler, and the power of parody --9.Nazis in Charlottesville, funeral protests, and speakers we hate --10.Social media and the "vast democratic forums of the Internet"."Media lawyer Ian Rosenberg distills the spectrum of free speech law down to ten critical issues. Each chapter in this book focuses on a contemporary free speech question--from student walkouts for gun safety to Samantha Bee's expletives, from neo-Nazis marching in Charlottesville to the muting of adult film star Stormy Daniels-- and then identifies, unpacks, and explains the key Supreme Court case that provides the answers"--Provided by the publisher.Freedom of speechUnited StatesCasesUnited StatesfastAlabama.Anarchist.Charlottesville.Civil Rights.Colin Kaepernick.Donald Trump.Draft.Education.Expletives.FCC.First Amendment.Free Press.Hate speech.Jehovah’s Witness.Law.Libel laws.Libel.Martin Luther King, Jr.NFL.National Anthem.Nazis.North Carolina.Pledge of Allegiance.Police brutality.President Trump.Protest.Racism.Radio.Richard Nixon.Rights.Saturday Night Live.Social Media.Stormy Daniels.Student protest.Supreme Court.Television.Trump.Vietnam War.Westboro Baptist Church.White supremacy.Women’s March.Freedom of speech342.730853Rosenberg Ian1219658MiAaPQMiAaPQUtOrBLWBOOK9910554237403321The fight for free speech2820094UNINA01898oam 2200541 450 991070982120332120181228115504.0(CKB)5470000002474048(OCoLC)961366255(OCoLC)995470000002474048(EXLCZ)99547000000247404820161028d1963 ua 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierProblems of utilizing ground water in the west-side business district of Portland, Oregon /by S.G. Brown[Washington, D.C.] :United States Department of the Interior, Geological Survey,1963.Washington :United States Government Printing Office.1 online resource (iv, 42 pages, 2 pages of plates) illustrations, mapContributions to the hydrology of the United StatesGeological Survey water-supply paper ;1619-O"Prepared in cooperation with the Oregon State Engineer."Includes bibliographical references (page 26).GroundwaterOregonPortlandUrban hydrologyOregonPortlandGroundwaterfastUrban hydrologyfastOregonPortlandfastGroundwaterUrban hydrologyGroundwater.Urban hydrology.Brown S. G(Stuart G.),1922-1394269Geological Survey (U.S.),Oregon.State Engineer.COPCOPOCLCOOCLCFGPOMERUCGPOBOOK9910709821203321Problems of utilizing ground water in the west-side business district of Portland, Oregon3470261UNINA