03040nam 22004935 450 991051058100332120210714013915.0981-336-198-010.1007/978-981-33-6198-0(CKB)5100000000115776(DE-He213)978-981-33-6198-0(EXLCZ)99510000000011577620210714d2021 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierGene Delivery[electronic resource] /edited by Huayu Tian, Xuesi ChenSingapore :Springer Singapore :Imprint: Springer,2021.1 online resource (X, 390 p. 200 illus.) Biomaterial Engineering,2523-8809Overview on gene therapy -- Cationic liposome -- Functionalized peptide dendrimers -- Bioresponsive poly(amido amine)s -- Cationic polyphosphoesters -- Polysaccharide-based gene carriers -- Polypeptide-based gene carriers -- Fluorinated gene carriers -- Target gene delivery systems -- Cationic helical polypeptides -- Cyclic cationic polymers -- Cationic bolaamphiphile -- Chitosan-functionalized gene carriers -- Charge-reversal gene carriers -- Multifunctional envelope-type nanodevice -- Drug and gene co-delivery systems -- Oral delivery of gene therapy -- Gene therapy for brain diseases.Gene delivery is a promising strategy for the specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been proved to be the most promising vehicles for clinical gene therapy due to their tunable size, shape, surface, and biological behaviors. In this volume, the recent developments of nanoparticles for clinical gene therapy will be identified and summarized.Biomaterial Engineering,2523-8809Biomedical engineeringBiomaterialsHuman geneticsBiomedical Engineering and Bioengineeringhttps://scigraph.springernature.com/ontologies/product-market-codes/T2700XBiomaterialshttps://scigraph.springernature.com/ontologies/product-market-codes/Z13000Human Geneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12008Biomedical engineering.Biomaterials.Human genetics.Biomedical Engineering and Bioengineering.Biomaterials.Human Genetics.610.28Tian Huayuedthttp://id.loc.gov/vocabulary/relators/edtChen Xuesiedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910510581003321Gene Delivery2852955UNINA