05361nam 2200517 450 991068834250332120160629092208.0(CKB)3710000000494914(WaSeSS)IndRDA00058600(oapen)https://directory.doabooks.org/handle/20.500.12854/60414(EXLCZ)99371000000049491420160629d2015 || |engur|||||||||||txtrdacontentcrdamediacrrdacarrierSynthetic biology engineering complexity and refactoring cell capabilities /edited by Francesca Ceroni, Karmella Ann Haynes, Pablo Carbonell and Jean Marie FrançoisFrontiers Media SA2015[Lausanne, Switzerland] :Frontiers Media SA,2015.1 online resource (123 pages)Frontiers Research Topics,1664-87142-88919-685-2 Includes bibliographical references.One of the key features of biological systems is complexity, where the behavior of high level structures is more than the sum of the direct interactions between single components. Synthetic Biologists aim to use rational design to build new systems that do not already exist in nature and that exhibit useful biological functions with different levels of complexity. One such case is metabolic engineering, where, with the advent of genetic and protein engineering, by supplying cells with chemically synthesized non-natural amino acids and sugars as new building blocks, it is now becoming feasible to introduce novel physical and chemical functions and properties into biological entities. The rules of how complex behaviors arise, however, are not yet well understood. For instance, instead of considering cells as inert chassis in which synthetic devices could be easily operated to impart new functions, the presence of these systems may impact cell physiology with reported effects on transcription, translation, metabolic fitness and optimal resource allocation. The result of these changes in the chassis may be failure of the synthetic device, unexpected or reduced device behavior, or perhaps a more permissive environment in which the synthetic device is allowed to function. While new efforts have already been made to increase standardization and characterization of biological components in order to have well known parts as building blocks for the construction of more complex devices, also new strategies are emerging to better understand the biological dynamics underlying the phenomena we observe. For example, it has been shown that the features of single biological components [i.e. promoter strength, ribosome binding affinity, etc] change depending on the context where the sequences are allocated. Thus, new technical approaches have been adopted to preserve single components activity, as genomic insulation or the utilization of prediction algorithms able to take biological context into account. There have been noteworthy advances for synthetic biology in clinical technologies, biofuel production, and pharmaceuticals production; also, metabolic engineering combined with microbial selection/adaptation and fermentation processes allowed to make remarkable progress towards bio-products formation such as bioethanol, succinate, malate and, more interestingly, heterologous products or even non-natural metabolites. However, despite the many progresses, it is still clear that ad hoc trial and error predominates over purely bottom-up, rational design approaches in the synthetic biology community. In this scenario, modelling approaches are often used as a descriptive tool rather than for the prediction of complex behaviors. The initial confidence on a pure reductionist approach to the biological world has left space to a new and deeper investigation of the complexity of biological processes to gain new insights and broaden the categories of synthetic biology. In this Research Topic we host contributions that explore and address two areas of Synthetic Biology at the intersection between rational design and natural complexity: (1) the impact of synthetic devices on the host cell, or "chassis" and (2) the impact of context on the synthetic devices. Particular attention will be given to the application of these principles to the rewiring of cell metabolism in a bottom-up fashion to produce non-natural metabolites or chemicals that should eventually serve as a substitute for petrol-derived chemicals, and, on a long-term view, to provide economical, ecological and ethical solutions to today’s energetic and societal challenges.Synthetic biologyBiotechnologymetabolism refactoringmetabolic pathway regulationsynthetic biologycomplexityengineering biologysynthetic expression circuitSynthetic biology.Biotechnology.Jean Marie Franauth1351521Ceroni FrancescaHaynes Karmella AnnCarbonell PabloFrançois Jean MarieWaSeSSWaSeSSBOOK9910688342503321Synthetic biology3114722UNINA04861 am 2200853 n 450 991050350810332120210728979-1-0938-3928-810.4000/books.cse.1138(CKB)4100000012059905(FrMaCLE)OB-cse-1138(oapen)https://directory.doabooks.org/handle/20.500.12854/87361(PPN)258323426(EXLCZ)99410000001205990520211027j|||||||| ||| 0freuu||||||m||||txtrdacontentcrdamediacrrdacarrierArt, Recherche et Animation Dans l’animation et la recherche : expérimentations artistiques. Quelles interactions pour quelles transformations ? /Cécile Croce, Chantal CrennBordeaux Carrières Sociales Editions20211 online resource (312 p.) des Paroles & des Actes979-1-0938-3923-3 Cet ouvrage fait suite au colloque international « Dans l’animation et dans la recherche : Expérimentations artistiques. Quelles interactions pour quelles transformations ? » organisé par l’ISIAT, l’IUT Bordeaux Montaigne et leurs partenaires. Ce colloque visait à décloisonner les discours et à croiser les pratiques professionnelles concernées par trois axes : animer, créer, chercher. Ces rencontres ont réuni plus d’une cinquantaine d’intervenants, animateurs, médiateurs, artistes, universitaires ainsi qu’un public nombreux autour de conférences, ateliers, expositions, interventions artistiques : installations, vidéos, expositions de toiles, de photographies, de plans, de dessins, exposition virtuelle, concert, spectacle théâtral avec des chevaux… Cette place offerte aux réalisations artistiques témoigne de l’égale considération donnée aux réalisations artistiques, aux projets d’animation, aux retours d’expériences, ou aux échanges scientifiques qu’il s’agissait, dans leurs différences, de travailler ensemble. En restant fidèle aux croisements et aux tissages opérés dans ces rencontres, le présent ouvrage donne la parole aux chercheurs soucieux de l’animation sociale et socioculturelle et de ses expérimentations artistiques, aux animatrices et animateurs intéressés par la recherche et l’art, aux artistes tentés par l’animation et par la recherche. Outre la grande vivacité à faire et à créer avec les publics, à s’engager tout en opérant des remises sur le chantier des actions, en toute humilité, le fil directeur d’Art, Recherche, Animation est sans doute également l’émotion qui se dégage des récits des échanges vécus, les moments de joie et les pleurs qui parfois ont débordé l’analyse. Il permet ainsi, prolongé par la réception de la lectrice ou du lecteur, d’esquisser quelques réponses aux questionnements du départ, à savoir comment parvenir à penser ensemble art, recherche et animation.Artrechercheanimation socioculturellepratique artisitiquerechercheanimation socioculturellepratique artisitiqueArtrechercheanimation socioculturellepratique artisitiqueArez Abel1292946Armellini Aurélie1292947Campos Joana1292948Choquet Isabelle1292949Crenn Chantal1290459Croce Cécile1292950Cruz Cristina1292951Dupont Jérôme1292952Felicio Pedro1292953Gama Ana1292954Godard Anne-Cécile1292955Grimal Michel1292956Laçage Jean-Christophe1292957Lasserre Marie1292958Loiseau Gaëlla1292959Lussier Martin1292960Martinez Aurélie1292961Naulet Aurélie1292962Navarro Murielle1292963Nobre Maria José1292964Nouhaud Nicolas1292965Pelissier Philippe1292966Peto Danièle1292119Pierre Alexandre1292967Poymiro Rémi1292968Richelle Jean-Luc1292969Rocha Carla1276945Rougier Thierry1292970Vohlgemuth Laurence1292971Zimmermann Michaël674275Croce Cécile1292950Crenn Chantal1290459FR-FrMaCLEBOOK9910503508103321Art, Recherche et Animation3022489UNINA