03552nam 22007215 450 991050266410332120251107172921.0981-16-5351-810.1007/978-981-16-5351-3(CKB)4100000012025947(MiAaPQ)EBC6725067(Au-PeEL)EBL6725067(OCoLC)1268205818(PPN)258058536(DE-He213)978-981-16-5351-3(EXLCZ)99410000001202594720210911d2021 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierChemical Master Equation for Large Biological Networks State-space Expansion Methods Using AI /by Don Kulasiri, Rahul Kosarwal1st ed. 2021.Singapore :Springer Nature Singapore :Imprint: Springer,2021.1 online resource (231 pages)Physics and Astronomy Series981-16-5350-X 1. Introduction -- 2. A Review and Challenges in Chemical Master Equation -- 3. Visualizing Markov Process through Graphs and Trees -- 4. Intelligent State Projection -- 5. Comparative Study And Analysis of Methods and Models -- 6. A Large Model Case Study: Solving CME for G1/S Checkpoint Involving the DNA-damage Signal Transduction Pathway -- 7. An Integrated Large Model Case Study: Solving CME for Oxidative Stress Adaptation in the Fungal Pathogen Candida Albicans.This book highlights the theory and practical applications of the chemical master equation (CME) approach for very large biochemical networks, which provides a powerful general framework for model building in a variety of biological networks. The aim of the book is to not only highlight advanced numerical solution methods for the CME, but also reveal their potential by means of practical examples. The case studies presented are mainly from biology; however, the applications from novel methods are discussed comprehensively, underlining the interdisciplinary approach in simulation and the potential of the chemical master equation approach for modelling bionetworks. The book is a valuable guide for researchers, graduate students, and professionals alike.Physics and Astronomy SeriesMathematical physicsComputer simulationBioinformaticsBiomathematicsComputational intelligenceArtificial intelligenceComputational Physics and SimulationsComputational and Systems BiologyMathematical and Computational BiologyComputational IntelligenceArtificial IntelligenceMathematical physics.Computer simulation.Bioinformatics.Biomathematics.Computational intelligence.Artificial intelligence.Computational Physics and Simulations.Computational and Systems Biology.Mathematical and Computational Biology.Computational Intelligence.Artificial Intelligence.574.192Kulasiri Don1065159Kosarwal RahulMiAaPQMiAaPQMiAaPQBOOK9910502664103321Chemical Master Equation for Large Biological Networks2557668UNINA