02752nam 22006375 450 991050263620332120251113185613.03-030-87324-210.1007/978-3-030-87324-0(CKB)5140000000013029(MiAaPQ)EBC6749163(Au-PeEL)EBL6749163(OCoLC)1276860028(PPN)258298073(DE-He213)978-3-030-87324-0(EXLCZ)99514000000001302920211011d2021 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierSARS-CoV-2 Spike Protein Convergent Evolution Impact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines /by Daniele Focosi1st ed. 2021.Cham :Springer International Publishing :Imprint: Springer,2021.1 online resource (140 pages)SpringerBriefs in Microbiology,2191-53933-030-87323-4 Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.SpringerBriefs in Microbiology,2191-5393VirologyImmunologyMedical microbiologyMicrobial geneticsVirologyImmunologyMedical MicrobiologyMicrobial GeneticsVirology.Immunology.Medical microbiology.Microbial genetics.Virology.Immunology.Medical Microbiology.Microbial Genetics.614.592414Focosi Daniele1072599MiAaPQMiAaPQMiAaPQBOOK9910502636203321SARS-CoV-2 Spike Protein Convergent Evolution2568871UNINA