11059nam 2200529 450 991049517930332120230424163006.03-030-73303-3(CKB)4100000011984158(MiAaPQ)EBC6682836(Au-PeEL)EBL6682836(PPN)260833819(EXLCZ)99410000001198415820220412d2021 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierOutcome measures and metrics in systemic lupus erythematosus /edited by Zahi ToumaCham, Switzerland :Springer,[2021]©20211 online resource (421 pages)Includes index.3-030-73302-5 Intro -- Preface -- Acknowledgment -- Contents -- Contributors -- Chapter 1: Introduction: Metrics and Domains Measured in SLE -- Introduction -- Core Set of Domains in SLE, Classification, and Response Criteria -- Core Domain 1: Disease Activity -- Core Domain 2: Chronic Damage Resulting from Lupus Activity or Its Treatment -- Disease Activity and Damage in Special Circumstances: Childhood and Pregnancy -- Childhood -- Pregnancy -- Core Domain 3: Health-Related Quality of Life -- Core Domains 4: Adverse Events of Drugs -- Core Domain 5: Economic Impact -- Emerging Concepts in SLE and Deep Insights on Selected Concepts -- Cognitive Impairment -- Depression and Anxiety -- Fatigue and Pain -- Frailty -- Instrument Selection: The OMERACT Process -- Facilitating Development of Response Criteria and Classification Criteria: EULAR/ACR Collaborative Projects -- Conclusion -- Bibliography -- Chapter 2: Clinical Aspects of Systemic Lupus Erythematosus -- Introduction -- Classification of SLE -- General Manifestations -- Cutaneous Manifestations -- Acute Cutaneous Lupus -- Chronic Cutaneous Lupus -- Non-specific Cutaneous Lesions -- Musculoskeletal Features -- Lupus Myositis -- Other Musculoskeletal Manifestations -- Renal Manifestations -- Neuropsychiatric Manifestations -- Gastrointestinal Involvement -- Mucocutaneous Lesions -- Lupus Enteritis -- Serositis -- Associated Hepatobiliary Manifestations -- Hematologic Manifestations -- Pulmonary Involvement -- Cardiac Manifestations -- Accelerated Atherosclerosis -- References -- Chapter 3: Diagnosis and Classification of Systemic Lupus Erythematosus -- Introduction -- Classification Criteria Are Not Diagnostic Criteria -- 2019 EULAR/ACR Classification Criteria -- Item Generation and New Insights About What Constitutes SLE -- Phase 2. Reducing the Number of Criteria and Other Lessons Learned.Phase 3. Weighting and Threshold Identification -- Phase 4. Validation -- Summary -- References -- Chapter 4: Challenges and Advances in SLE Autoantibody Detection and Interpretation -- Introduction -- Important Considerations in Interpretation of ANA Test Results and Reports -- Specific Autoantibodies -- Chromatin Components -- Double-Stranded DNA -- Histones -- Nucleosomes -- High-Mobility Group Proteins -- Dense Fine Speckled (DFS) -- Small Nuclear Ribonucleoproteins: Sm and U1-RNP -- DNA-Dependent Protein Kinase (DNA-PK/Ku) -- Other Nuclear Targets -- Sjögren Syndrome Antigen B/La -- Cytoplasmic -- Ribosomal P -- Ro60/SSA -- Ro52/TRIM21 -- Cell Cycle -- Proliferating Cell Nuclear Antigen -- Extracellular -- C1q -- Phospholipids and Related Antigens [128] -- Cardiolipin -- β2-glycoprotein 1 -- Non-criteria Autoantibodies: Phosphatidylserine/Prothrombin Complex -- Orphan Autoantibodies -- Summary -- References -- Chapter 5: Childhood-Onset Systemic Lupus Erythematosus (cSLE): Is It Really Different Than Adult-Onset SLE? -- Introduction -- What Is cSLE? -- Epidemiology -- Incidence and Prevalence -- Sex Predominance -- Genetics -- Classification Criteria -- Race -- Race and Disease Manifestations Overall -- Race, Disease Manifestations, and Age of Onset -- Race, SLE Outcomes, and Age of Onset -- Medication Use -- Growth and Development -- Mental Health -- Social Outcomes -- Summary -- References -- Chapter 6: Metrics in Disease Activity Measures in Systemic Lupus Erythematosus -- Introduction -- Principles for the Assessment of SLE Patients -- Disease Activity Indices -- Global Indices -- Systemic Lupus Erythematosus Disease Activity Index and Its Versions -- Mexican Version of the SLEDAI (Mex-SLEDAI) -- Safety of Estrogens in Lupus Erythematosus National Assessment Trial (SELENA)-SLEDAI -- SLEDAI-2000 (SLEDAI-2K) -- SLEDAI-2K: 30-Day Version.SLEDAI-2K Glucocorticoid Index (SLEDAI-2KG) -- Systemic Lupus Activity Measure (SLAM) -- European Consensus Lupus Activity Measurement (ECLAM) -- Lupus Activity Index -- SLE Activity Index Score -- British Isles Lupus Assessment Group (BILAG) Index -- Organ-Specific Indices -- Renal Outcome Measures -- Cutaneous Lupus Erythematosus Disease Area and Severity Index -- Measures of Disease Activity over Time -- Adjusted Mean SLEDAI-2K -- Responder Measures -- Flares -- Improvement -- Responder Index for Lupus Erythematosus -- SLE Responder Index -- BILAG-Based Composite Lupus Assessment (BICLA) -- SLEDAI-2K Responder Index 50 -- Measures of Clinically Meaningful Change in Disease Activity -- Improvement -- Flare and Persistently Active Disease -- Assessment of Disease Activity in Special Patient Groups -- Childhood -- Pregnancy -- Low Disease Activity in SLE -- References -- Chapter 7: Metrics of Damage in SLE -- The Concept of Damage in SLE -- Conceptualization and Development of a Damage Index -- SLICC/ACR Damage Index (SDI) and Adaptations -- Psychometric Properties: Putting SDI to the Test -- Validity Measures -- Reliability and Sensitivity to Change -- Predicative Ability -- Critical Appraisal and Overall Value of SDI -- Next Steps -- References -- Chapter 8: Metrics and Outcome Measures of Disease Activity and Damage in Childhood-Onset Systemic Lupus Erythematosus -- Introduction -- Disease Measures of Global Disease Activity -- Systemic Lupus Erythematosus Disease Activity Index -- Safety of Estrogens in Lupus National Assessment-Systemic Lupus Erythematosus Disease Activity Index and Flare Tool -- Systemic Lupus Activity Measure -- Systemic Lupus Activity Questionnaire -- British Isles Lupus Assessment Group Index -- European Consensus Lupus Activity Measurement -- Disease Measure of Global Damage in cSLE.Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index -- Measures of Flare and Response to Therapy for Use in cSLE -- BILAG Flare Tool -- Systemic Lupus Erythematosus Responder Index -- Pediatric-Specific Measures of Clinically Relevant Change in SLE Course -- Pediatric Rheumatology International Trials Organization Provisional Criteria of Response to Therapy -- Childhood Lupus Improvement Index -- Organ-Specific Measures -- Lupus Nephritis,Response to Therapy and Lupus Nephritis Flare -- Renal Activity Index for Lupus Nephritis -- Cutaneous Lupus Erythematosus Disease Area and Severity Index -- Pediatric Automated Neuropsychological Assessment Metrics -- Health-Related Quality of Life and Other Patient-Reported Outcomes -- Child Health Questionnaire -- Simple Measure of Impact of Lupus Erythematosus in Youngsters -- Pediatric Quality of Life Inventory -- Functional Disability Inventory -- Pediatric Skindex-27 -- Patient-Reported Outcomes Measurement Information System -- Summary -- References -- Chapter 9: Pregnancies in Lupus: Monitoring and Metrics -- Pregnancy Outcomes in SLE -- Monitoring -- Metrics in Observational Studies of SLE Pregnancies -- Administrative Databases -- Claim-Based Databases -- Population-Based Registers -- Advantages of Administrative Databases for Reproductive Studies in SLE -- Prospective Pregnancy Cohorts -- Limitations in Observational Studies of Reproductive Outcomes in SLE: Differences Between Pregnancy and Birth -- Early Pregnancy Complications and Loss -- Timing of Pregnancy -- Parity and Repeated Events -- Measuring Drug Exposures -- Ascertaining Congenital Malformations -- Unmeasured Confounders -- Immortal Time Bias -- Timing of SLE Diagnosis in Relation to Pregnancy -- Conclusion -- References -- Chapter 10: Digital Data in Lupus: Metrics and Future Directions.Introduction -- Section I: Major Types of Digital Data -- Electronic Health Records -- Administrative Data -- Registries -- Biobank Data with Linkage -- Social Media -- Wearables -- Section II: Caveats -- Defining SLE -- Incomplete Information -- Misclassification and Measurement Error -- Selection Bias -- Future Directions -- References -- Chapter 11: Patient-Reported Outcomes in SLE -- Overview of Current PRO Measures -- Generic Patient-Reported Outcomes -- Medical Outcomes Survey Short Form 36 (SF-36) -- The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Scale -- National Institute of Health Initiative Patient-Reported Outcome Measurement Information System (PROMIS) Global Health -- Disease-Specific PROs -- LupusQoL -- LupusPRO -- Lupus Impact Tracker (LIT) -- Additional PROs -- Use as Cost-Utility Measures -- SF-6D -- Euro-QoL 5D -- Application of PROs -- Logistical Considerations for Implementation -- Interpretation of PROs -- Illustration of Potential Clinical Use: Spydergrams -- Increasing Actionability -- References -- Chapter 12: Assessment of Health-Related Quality of Life in Systemic Lupus Erythematosus -- Introduction -- How Can Systemic Lupus Erythematosus Affect the Patient's Quality of Life? -- Why Is It Important to Measure Health-Related Quality of Life in Systemic Lupus Erythematosus? -- Measures Used for Assessing Health-Related Quality of Life in Systemic Lupus Erythematosus and Comparisons Between These Measures -- Generic and Condition-Specific Measures Used in Adults with SLE -- SLE-Specific Health-Related Quality of Life Measures for Use in Adults -- Systemic Lupus Erythematosus Quality of Life (L-QoL) -- Systemic Lupus Erythematosus Symptom Checklist (SSC) -- Systemic Lupus Erythematosus Quality of Life (SLEQOL) -- LupusQoL -- Lupus Patient-Reported Outcome (LupusPRO) -- Lupus Impact Tracker (LIT).Comparison of Psychometric Properties of Adult Health-Related Quality of Life Measures in Systemic Lupus Erythematosus.Systemic lupus erythematosusDiagnosisLupus eritematósthubDiagnòsticthubLlibres electrònics.thubSystemic lupus erythematosusDiagnosis.Lupus eritematósDiagnòstic.616.772Touma ZahiMiAaPQMiAaPQMiAaPQBOOK9910495179303321Outcome Measures and Metrics in Systemic Lupus Erythematosus2785252UNINA00996nam0 22002651i 450 UON0010316620231205102602.82120020107d1976 |0itac50 baaraIQ|||| 1||||Dawud Basa wa nihayat al-Mamalik fi'l-'IraqYusuf 'Izz al-DinBagdadGami'at Bagdad19761 v.24 cmIQBaġdādUONL000447IRQ IVIRAQ - STORIAAIZZ al-DINYusufUONV013031640688Gami'at BagdadUONV261017650IZZIDIEN, YousifIZZ al-DIN, YusufUONV165099ITSOL20240220RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00103166SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI IRQ IV 006 SI SA 12434 5 006 Dawud Basa wa nihayat al-Mamalik fi'l-'Iraq1311029UNIOR06220oam 2201093 c 450 991013125810332120260202090927.03-7639-4066-99783763940660(CKB)3710000000420584(EBL)1189084(OCoLC)862939682(SSID)ssj0001558905(PQKBManifestationID)16184466(PQKBTitleCode)TC0001558905(PQKBWorkID)14819653(PQKB)11777786(MiAaPQ)EBC1189084(wbv Publikation)9783763940660(EXLCZ)99371000000042058420260202d2013 uy 0gerur|n|---|||||txtccrDer Arbeitskräftebedarf in Deutschland 2006 bis 2011 Nachfrage, Rekrutierungsprozesse und Engpässe aus Sicht der Betriebe /Institut für Arbeitsmarkt- und Berufsforschung (IAB) der Bundesagentur für Arbeit, Alexander Kubis, Ute Leber, Anne Müller, Jens Stegmaier1st ed.Bielefeldwbv Publikation20131 online resource (98 p.)IAB-Bibliothek339Description based upon print version of record.3-7639-4065-0 Includes bibliographical references.Vorwort 1 Betrieblicher Arbeitskräftebedarf - das Wichtigste in Kürze 1.1 Aufgaben und Ziele 1.2 Verwendete Datenquellen 1.3 Zentrale Ergebnisse 2 Arbeitskräftenachfrage - wen braucht die Wirtschaft? 2.1 Überblick 2.3 Entwicklung der Regionen 2.4 Entwicklung der Branchen 2.5 Entwicklung nach Betriebsgrößen 2.6 Entwicklung nach Berufen 2.7 Zentrale Ergebnisse des zweiten Kapitels 3 Anzeichen für Arbeitsmarktengpässe 3.1 Überblick 3.2 Gesamtwirtschaftliche Situation 3.3 Engpasssituation in den Regionen 3.4 Engpassanalyse nach Wirtschaftszweigen 3.5 Engpassanalyse nach Berufen 3.6 Kompromisse und erfolglose Rekrutierungsprozesse 3.7 Zentrale Ergebnisse des dritten Kapitels 4 Literatur 5 Anhang KurzfassungDas Thema Fachkräftebedarf wird in Wissenschaft und Öffentlichkeit intensiv und kontrovers diskutiert. Der Bericht analysiert die Arbeitskräftenachfrage der Betriebe und versucht, aktuelle Engpässe auf dem Arbeitsmarkt zu identifizieren. Zunächst wird die Entwicklung der Betriebs- und Beschäftigungsstruktur sowie der offenen Stellen differenziert für verschiedene Teilarbeitsmärkte dargestellt. Weiterhin werden verschiedene Indikatoren diskutiert, die Hinweise auf Arbeitskräfteengpässe geben können. Insgesamt zeigen die Ergebnisse, dass in Deutschland derzeit kein allgemeiner, flächendeckender Fachkräftemangel besteht. Dennoch sind bestimmte Berufe, Regionen und Branchen zu erkennen, in denen die Engpässe zugenommen haben. Dies gilt etwa für Berufe aus dem Gesundheits- und Sozial-, aber auch dem Elektrobereich. Auf regionaler Ebene treten Fachkräfteengpässe am ehesten in den süddeutschen Bundesländern auf, im Branchenvergleich scheinen Engpässe vornehmlich in einzelnen Dienstleistungsbereichen zu bestehen. The topic of skilled labour requirements is discussed intensively and controversially in sciences and in public. The publication analyses the labour force requirements of companies and attempts to identify current shortage trends on the labour market. Initially, the development of company and employment structures as well as of vacancies is presented in relation to various partial employment markets. Furthermore, the different indicators providing clues for labour force shortages are discussed. Overall, the results show that currently there is no general, extensive shortage of skilled labour in Germany. However, there are trends visible in certain professions, areas and sectors where the shortages have increased. This applies, for example, to professions in the health care system, the social care system and the electrical sector. As for local divergences, the skilled labour shortages are most likely in the Southern German states, whilst the comparison of sectors suggests that above all the individual service providing sectors seem to experience shortages.IAB-Bibliothek ;339.FachkräftemangelPersonalArbeitsmarktArbeitskräfteArbeitskräftebedarfWirtschaftszweigeIAB-Betriebspanelregionale DisparitätFachkräfteArbeitskräftenachfrageDienstleistungsbereichoffene StellenPersonalbeschaffungLaufzeitBeschäftigungBundesländerBerufsgruppeRekrutierungFachkräftebedarfIAB-Erhebung des gesamtwirtschaftlichen Stellenangebotslabour marketArbeitsmärkteFachkräftemangelPersonalArbeitsmarktArbeitskräfteArbeitskräftebedarfWirtschaftszweigeIAB-Betriebspanelregionale DisparitätFachkräfteArbeitskräftenachfrageDienstleistungsbereichoffene StellenPersonalbeschaffungLaufzeitBeschäftigungBundesländerBerufsgruppeRekrutierungFachkräftebedarfIAB-Erhebung des gesamtwirtschaftlichen Stellenangebotslabour marketArbeitsmärkte331.120941Kubis AlexanderautLeber UteautMüller AnneautStegmaier JensautInstitut für Arbeitsmarkt- und Berufsforschung (IAB) der Bundesagentur für ArbeitedtMiAaPQMiAaPQMiAaPQBOOK9910131258103321Der Arbeitskräftebedarf in Deutschland 2006 bis 20112781035UNINA