10785nam 2200589 450 991048469680332120231110232209.03-030-62289-4(CKB)4100000011807175(MiAaPQ)EBC6525759(Au-PeEL)EBL6525759(OCoLC)1243307545(PPN)254720382(EXLCZ)99410000001180717520211015d2021 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierHeat shock proteins in human diseases /Alexzander A. A. Asea and Punit Kaur (editors)Cham, Switzerland :Springer,[2021]©20211 online resource (301 pages) illustrationsHeat Shock Proteins ;v.213-030-62288-6 Includes bibliographical references and index.Intro -- Preface -- Contents -- About the Editors -- Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and ... -- 1 Introduction -- 2 Cancer, Inflammation and HSP -- 2.1 Role of Inflammation in Cancer Development -- 2.2 Role of Heat Shock Proteins (HSP) in Cancer Development -- 2.3 Relationship Between HSP and Inflammation in Cancer Development -- 3 Role of the Immune System and HSP in Cancer Diagnosis and Prevention -- 3.1 Ingenious Tumour Immune Surveillance Mechanism to Prevent Cancer -- 3.2 HSP as a Biomarker for Cancer Diagnosis -- 3.3 Targeting the HSP-Inflammation Cooperative System as a Target for Cancer Diagnosis Therapeutics -- 3.4 HSP Based Cancer Immunotherapy -- 3.4.1 Vaccines Based on HSP -- 3.4.2 Immune Responses Stimulation Using HSP as an Antigen -- 3.4.3 The Application of HSP as an Adjuvant for the Immune System Stimulation -- 4 Conclusions -- References -- Chaperonin Hsp60 and Cancer Therapies -- 1 Introduction -- 2 Human Hsp60 and Its Bacterial Orthologues -- 2.1 Hsp60 vs. GroEL -- 2.2 Hsp60 and Autoimmune Diseases -- 3 Hsp60 in Carcinogenesis -- 3.1 Chaperonopathy by Mistake -- 3.2 Hsp60 in Cancer -- 4 Hsp60 in Cancer Management -- 4.1 Exosomes: Definition and Biogenesis -- 4.2 Exosomes in Disease: Cancer -- 4.3 Exosomal Hsp60 in Tumorigenesis -- 5 Hsp60 in Cancer Therapy -- 5.1 Hsp and the Immune System -- 5.2 Hsp60-Associated Vaccines in Tumors -- 5.3 Exosomal Hsp60 for Tumor Therapy -- 6 Conclusions -- References -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- 1 Introduction -- 1.1 Heat Shock Proteins in Cancer Cells -- 1.1.1 Intracellular HSP -- 1.1.2 Extracellular HSP in Cancer -- 1.2 Heat Shock Protein Modulation as a Target for Cancer Therapy -- 1.2.1 Targeting Hsp90 -- 1.2.2 Targeting Hsp70.1.2.3 Targeting Hsp60 in Cancer -- 1.2.4 Targeting Hsp27 in Cancer -- 1.3 Targeted Cancer Thermotherapy -- 1.3.1 Nanoparticles in Cancer Therapy -- 1.3.2 SPIONs -- 1.3.3 Synthesis Approaches -- 1.3.4 Chemical Synthesis: Co-precipitation -- 1.3.5 SPIONs Enhancement: Surface Functionalization -- 1.3.6 Targeting -- 1.3.7 Magnetic Field-Induced Hyperthermia -- 1.4 Combined HSP Targeting with Hyperthermia -- 2 Conclusions -- References -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Ther... -- 1 Introduction -- 2 HSR Inhibitors Currently in Human Clinical Studies (Table 1 and Fig. 2) -- 2.1 Quercetin -- 2.2 QC12 (Analog Prodrug of Quercetin) -- 2.3 Triptolide -- 2.4 Minnelide (Analog Prodrug of Triptolide) -- 3 HSR Inhibitors Currently in Preclinical Animal Studies (Table 2 and Fig. 3) -- 3.1 PW3405 -- 3.2 Cantharidin -- 3.3 KNK437 -- 3.4 KRIBB11 -- 3.5 Fisetin -- 3.6 Racoglamide A -- 3.7 CCT251236 -- 4 HSR Inhibitors in Early Preclinical Studies (Cancer Cell Lines, Table 3 and Fig. 4) -- 5 Lessons Learned from Preclinical and Clinical Studies -- 5.1 Improvement of Therapeutic Window by Prodrug Design and Nanoparticle Packaging -- 5.2 Combined Application with Chemotherapy Drugs or Drugs against a Different Cancer Target -- 5.3 Target Validation and Use of RNA Aptamer -- 5.4 HSF1 as a Potential Biomarker for Clinical Trial Design and Prognosis Prediction -- 6 Conclusions -- References -- Multifaceted Roles of Heat Shock Factor 1 (HSF 1) in Cancer -- 1 Introduction -- 2 HSF1 Becomes Constitutively Activated Within Cancer Cells -- 2.1 Activation of HSF1 by the Oncogenic RAS Signaling Pathway -- 2.2 Activation of HSF1 by Other Oncogenic Signaling Pathways -- 2.3 Inactivation of HSF1 by Metabolic Stress Signaling -- 2.4 Other Signaling Pathways Suppress HSF1 Through Phosphorylation.3 HSF1 Enables Oncogenesis Through Multifaceted Mechanisms -- 3.1 Guarding Proteomic Stability in Cancer -- 3.2 Preventing Cell Senescence and Promoting Survival -- 3.3 Contributing to Genomic Instability and Alleviating Genotoxic Stress -- 4 Enhancing Tumor Cell Invasion and Metastasis -- 4.1 Augmenting Critical Oncogenic Signaling Pathways -- 4.2 Reprogramming Cancer Metabolism -- 4.3 Modulating Tumor Immune Evasion -- 4.4 Promoting Oncogenic Growth Non-cell-autonomously -- 5 HSF1 Is a Potential Therapeutic Target and Prognostic Marker -- 6 Conclusions -- References -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- 1 Introduction -- 2 Heat Shock Proteins -- 3 Mode of Action -- 4 HSP27 -- 5 HSP40 -- 6 HSP60 -- 7 HSP70 -- 8 HSP90 -- 9 Differential Expression of Hsp in Gastric Cancer -- 10 HSP70 -- 11 HSP40 -- 12 HSP60 -- 13 Hsp27 -- 14 HSP90 -- 15 Diagnostic and Prognostic Applications of HSP in Gastric Cancer -- 16 HSP70 in H. pylori and EBV Positive Gastric Cancer -- 17 Genetic Polymorphism of HSP70 in Gastric Cancer -- 18 Inhibitors of HSP -- 19 HSP70 Based Vaccines -- 20 Conclusions -- References -- Heat Shock Proteins in Atrial Fibrillation -- 1 Introduction -- 2 HSP and Electrical Remodeling in AF -- 3 HSP and Structural Remodeling in AF -- 4 HSP and Inflammatory Reactions in AF -- 5 HSP and Oxidative Stress in AF -- 6 Clinical Application of HSP -- 7 Conclusions -- References -- Threading Microarrays into Novel Applications -- 1 Introduction -- 1.1 HSP90 as a Stress Marker -- 1.2 HSP90-Oriented Screening of Compound Libraries by the Use of Protein Microarrays (PMA) -- 1.3 Novel Applications by Protein Microarrays (PMA) -- 1.3.1 Quantum Dots as a Sensor for Biomarker -- Studying Mutational Effects by PMA -- 2 Conclusions -- References.Regulation of Kaposi´s Sarcoma-Associated Herpesvirus Biology by Host Molecular Chaperones -- 1 Introduction -- 1.1 KSHV Lifecycle and Biology -- 1.2 KSHV Structure -- 1.3 KSHV Associated Malignancies -- 1.4 KSHV, Protein Folding and Molecular Chaperones -- 1.5 KSHV and Hsp90 -- 1.6 Hsp70 and KSHV -- 1.7 Endoplasmic Reticulum Chaperones and KSHV -- 1.8 KSHV and Nucleophosmin -- 1.9 Putative Candidate KSHV Chaperone Clients Inferred from Proteomics Datasets -- 2 Conclusions -- References -- Role of Heat Shock Factors in Diseases and Immunity -- 1 Introduction -- 1.1 Heat Shock Factors - Functions, Characteristics, Organization and Role in Diseases -- 1.1.1 Heat Shock Response and Importance of HSF -- 1.1.2 Organization and Regulation of HSF -- 1.1.3 PTMs and HSF -- 1.1.4 Importance of Small Molecules in HSF Activation -- 1.1.5 Relationship Between HSF, Diseases and Immunity -- HSF and Cancer -- HSF and Neurodegenerative Diseases -- HSF and Bacterial Infections -- 1.1.6 HSF and Its Turnover Mechanism -- 2 Conclusions -- References -- Heat Shock Proteins and Pain -- 1 Introduction -- 1.1 Inflammation and Pain -- 1.1.1 Pain Signaling -- 1.1.2 Inflammation and Pain -- 1.2 Heat Shock Proteins and Pain -- 1.2.1 Small Heat Shock Proteins(sHsp) -- 1.2.2 Heat Shock Protein 60 (Hsp60) -- 1.2.3 Heat Shock Protein 70 (Hsp70) -- 1.2.4 Heat Shock Protein 90 (Hsp90) -- 1.3 Heat Shock Proteins and Pain Management -- 1.3.1 sHsp -- 1.3.2 Hsp70 -- 1.3.3 Hsp90 -- 2 Conclusions -- References -- HSF1 Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- 1 Introduction -- 1.1 Cellular Senescence -- 1.2 Acute Depletion of HSF1 Induces Cellular Senescence -- 1.3 Role of HDIS in Tumorigenesis -- 1.3.1 The DHRS2-MDM2-p53 Pathway -- 1.4 Role of HDIS in Age-Related Pathologies -- 2 Conclusions -- References.Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with Diverse Cellular... -- 1 Introduction -- 1.1 Regulation of Heat Shock Proteins by HSF1 -- 1.2 Functions of Heat Shock Proteins -- 1.3 Characteristics of Intrinsically Unstructured/Disordered Protein (IUP/IDP) -- 1.4 Huntingtin Yeast Two-Hybrid Protein K (HYPK) Is an Intrinsically Unstructured/Disordered Protein (IUP/IDP) -- 1.5 In Vitro and In Vivo Chaperone Activity of HYPK -- 1.6 HYPK Binds with Newly Synthesized Peptides/Proteins -- 1.7 HYPK Interacting Proteins -- 1.8 Chaperones Are in Hub of Protein-Protein Interaction Network -- 1.9 HYPK Is Associated with Aggregate Prone Proteins -- 1.10 Thermal Stress, Hypoxia and Proteasome Inhibitor MG132 Enhance Expression of HYPK in Cultured Cells -- 1.11 HSF1 Binds to the Promoter Sequence of HYPK and Regulates the Expression -- 1.12 HYPK Negatively Regulates Heat Shock Response -- 1.13 HSF1 Also Regulate HYPK Conjoined SERF2 Gene -- 1.14 Functions of HYPK -- 1.15 Does HYPK Modify Expression of Other Genes? -- 1.16 Does HYPK Play Any Role Human Disease? -- 2 Conclusions -- References -- Roles of HSP on Antigen Presentation -- 1 Introduction -- 1.1 Mechanisms of Antigen Presentation by Dendritic Cells -- 1.2 Roles of HSP in Antigen Presentation by MHC-I -- 1.3 Roles of HSP in Antigen Presentation by MHC-II -- 2 Conclusions -- References -- Heat Shock Proteins Mediate Anastasis and Plasticity of Thermotolerant Cells -- 1 Introduction -- 2 Apoptosis -- 2.1 The Role of Mitochondria in Apoptosis -- 2.2 The Role of Death Receptors in Apoptosis -- 3 Thermotolernce and Anastasis -- 4 Role of HSP in Anastasis -- 5 Conclusions and Perspectives -- References -- Index.Heat Shock Proteins Heat shock proteinsPhysiological effectProteïnesthubNeuroimmunologiathubMalaltiesthubLlibres electrònicsthubHeat shock proteinsPhysiological effect.ProteïnesNeuroimmunologiaMalalties572.6Asea Alexzander A. A.Kaur PunitMiAaPQMiAaPQMiAaPQBOOK9910484696803321Heat shock proteins in human diseases1892952UNINA02003nam 2200457 450 991081483810332120200123085826.02-8062-5966-5(CKB)3790000000017702(EBL)2066186(OCoLC)911001237(MiAaPQ)EBC2066186(Au-PeEL)EBL2066186(PPN)233410325(EXLCZ)99379000000001770220200123d2015 uy 0freur|n|---|||||txtrdacontentcrdamediacrrdacarrierLa commune de 1871, quand Paris s'insurge une révolution au destin tragique /par Mélanie MettraNamur :50Minutes,[2015]©20151 online resource (44 p.)Grands événements ;Numéro 25Description based upon print version of record.2-8062-5967-3 Includes bibliographical references. Découvrez enfin tout ce qu'il faut savoir sur la Commune de Paris en moins d'une heure !Entre 1789 et 1871, la France connaît de nombreux soubresauts politiques. Entre révolutions, tentatives républicaines, restauration de la monarchie et prestige impérial, elle n'a pas eu un instant de répit. En 1870, sa cuisante défaite contre la Prusse attise à nouveau la colère du peuple. Du 18 mars au 28 mai 1871, un dernier soulèvement secoue Paris et aboutit à la constitution d'une Commune autonome. Rapidement, des premières mesures sont prises pour rétablir la liberté de la presse, instaurer la laïcitGrands ÉvénementsParis (France)HistoryCommune, 1871944.36081Mettra Mélanie1116635MiAaPQMiAaPQMiAaPQBOOK9910814838103321La commune de 1871, quand Paris s'insurge4043195UNINA