03363oam 2200493 450 991048415470332120210617101955.03-030-54630-610.1007/978-3-030-54630-4(CKB)5410000000054450(MiAaPQ)EBC6455849(DE-He213)978-3-030-54630-4(PPN)252509099(EXLCZ)99541000000005445020210617d2021 uy 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierIntroduction to antibody engineering /Florian Rüker, Gordana Wozniak-Knopp, editors1st ed. 2021.Cham, Switzerland :Springer,[2021]©20211 online resource (VIII, 388 p. 69 illus., 52 illus. in color.) Learning materials in biosciences3-030-54629-2 Chapter 1. Introduction by the editors -- Chapter 2. Antibodies – A History of their Discovery and Properties -- Chapter 3. Monoclonal Antibodies and Hybridomas -- Chapter 4. Antibody Display Systems -- Chapter 5. Transgenic Animals for the Generation of Human Antibodies -- Chapter 6. Applications of Antibodies in Therapy, Diagnosis & Science -- Chapter 7. Bispecific antibodies -- Chapter 8. Antibody-Drug Conjugates -- Chapter 9. Alternative Binding Scaffolds – multipurpose binders for applications in basic research and therapy -- Chapter 10: Chimeric antigen receptor (CAR) redirected T cells -- Chapter 11. Improvement of Key Characteristics of Antibodies -- Chapter 12. Engineering therapeutic antibodies for development -- Chapter 13. Eukaryotic expression systems for upstream pro-cessing of monoclonal antibodies -- Chapter 14. Antibody Validation.This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.Learning materials in biosciences.ImmunotechnologyImmunoglobulinsImmunotechnology.Immunoglobulins.615.37Rüker FlorianWozniak-Knopp GordanaMiAaPQMiAaPQUtOrBLWBOOK9910484154703321Introduction to antibody engineering2804052UNINA