05188nam 2200649Ia 450 991045230700332120200520144314.01-299-46292-81-84816-837-3(CKB)2550000001019212(EBL)1168140(SSID)ssj0000908051(PQKBManifestationID)11943990(PQKBTitleCode)TC0000908051(PQKBWorkID)10898843(PQKB)11193598(MiAaPQ)EBC1168140(WSP)00002961(Au-PeEL)EBL1168140(CaPaEBR)ebr10699131(CaONFJC)MIL477542(OCoLC)841913828(EXLCZ)99255000000101921220040914d2013 uy 0engur|n|---|||||txtccrThe neutrophils[electronic resource] new outlook for old cells /editor, Dmitry I. Gabrilovich3rd ed.London Imperial College Press ;Singapore ;Hackensack, NJ Distributed by World Scientific Pub.c20131 online resource (447 p.)Description based upon print version of record.1-84816-836-5 Includes bibliographical references and index.List of Contributors; Preface; Contents; Chapter 1: Molecular Regulation of Granulopoiesis Sachin Kumar and Marie-Dominique Filippi; 1.1 Introduction; 1.2 Sequential Steps of PMN Development; 1.2.1 From HSC to granulocytic precursors; 1.2.2 Final stages of granulocytic maturation - Acquisition of granulocyte characteristics; 1.3 Regulation of Steady State Granulopoiesis; 1.3.1 Growth factors; 1.3.1.1 G-CSF: Sources and functions; 1.3.1.2 G-CSFR and downstream signaling pathways; 1.3.1.3 G-CSFR signaling: Instructive or permissive?; 1.3.2 Transcription factors (TF)1.3.2.1 PU.1 - Generation of CMP from HSC1.3.2.2 C/EBPα - Generation of GMP from CMP; 1.3.2.3 C/EBPε - Terminal stages of differentiation; 1.3.2.4 Gfi-1 - Terminal stages of differentiation; 1.3.2.5 Other transcription factors important for granulopoiesis; 1.3.2.5.1 Retinoic acid receptors; 1.3.2.5.2 HoxA10; 1.3.2.5.3 LEF-1; 1.3.3 MicroRNA; 1.3.4 Cell cycle regulation; 1.4 Emergency Granulopoiesis; 1.5 Conclusion; References; Chapter 2: The Neutrophil Respiratory Burst Oxidase Mark T. Quinn; 2.1 Introduction; 2.2 NADPH Oxidase Components; 2.2.1 Flavocytochrome b; 2.2.2 p47phox; 2.2.3 p67phox2.2.4 p40phox2.2.5 Rac; 2.2.6 Rap1A; 2.3 Oxidase Protein Binding Interactions; 2.3.1 Flavocytochrome b-p47phox interactions; 2.3.2 p40phox-p47phox-p67phox interactions; 2.3.3 Rac interactions; 2.4 Model of NADPH Oxidase Assembly; 2.5 Oxidant Production; 2.5.1 Superoxide anion (O2 -); 2.5.2 Hydrogen peroxide (H2O2); 2.5.3 Hypochlorous acid (HOCl); 2.5.4 Hydroxyl radical (HO); 2.5.5 Singlet oxygen ( 1O2 *); 2.5.6 Nitric oxide (NO) and peroxynitrite (ONOO-); 2.7 Summary; Acknowledgments; ReferencesChapter 3: Novel Neutrophil Receptors and Their Signal Transduction Nicole R. Fortenbery, Xianhong Chen and Sheng Wei3.1 Introduction; 3.2 Siglecs; 3.2.1 Identification of siglecs; 3.2.2 Characterization of siglecs; 3.2.3 Siglec-5; 3.2.4 Siglec-9; 3.2.5 Siglec-14; 3.2.6 Siglec signaling; 3.2.7 Clinical applications; 3.3 Triggering Receptor Expressed by Myeloid Cells (TREM); 3.3.1 Identification of TREM; 3.3.2 Characterization of TREM-1; 3.3.3 TREM-1-DAP12 and signal transduction; 3.3.4 TREM-1 ligand(s); ReferencesChapter 4 Mechanisms of Neutrophil Migration Fong W. Lam, Rolando E. Rumbaut and Alan R. Burns4.1 Introduction; 4.2 Historical Perspective on Leukocyte Adhesion and Emigration (1669-1955); 4.2.1 The first observations; 4.2.2 Mechanistic insight; 4.3 Molecular Adhesive Events Preceding Neutrophil Transendothelial Migration; 4.4 Integrin Regulation of Neutrophil Transendothelial Migration; 4.5 Paracellular Neutrophil Transendothelial Migration; 4.5.1 Endothelial cleft organization; 4.5.2 Tight junctions and preferred transmigration sites; 4.5.3 Adherens junctions; 4.5.4 Gap junctions4.5.5 PECAM-1This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death ofNeutrophilsImmunologyElectronic books.Neutrophils.Immunology.571.96Gabrilovich Dmitry I912645MiAaPQMiAaPQMiAaPQBOOK9910452307003321The neutrophils2043963UNINA04917nam 22008055 450 991048412640332120251226195341.010.1007/b107118(CKB)1000000000212890(SSID)ssj0000591258(PQKBManifestationID)11352043(PQKBTitleCode)TC0000591258(PQKBWorkID)10692557(PQKB)11186277(DE-He213)978-3-540-31957-3(MiAaPQ)EBC3067735(PPN)14903640X(EXLCZ)99100000000021289020100707d2005 u| 0engurnn#008mamaatxtccrNetworking -- ICN 2005 4th International Conference on Networking, Reunion Island, France, April 17-21, 2005, Proceedings, Part II /edited by Pascal Lorenz, Petre Dini1st ed. 2005.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2005.1 online resource (XXXV, 1153 p.)Computer Communication Networks and Telecommunications,2945-9184 ;3421Bibliographic Level Mode of Issuance: Monograph3-540-31957-3 3-540-25338-6 Includes bibliographical references and indexes.MIMO -- MPLS -- Ad Hoc Networks (I) -- TCP (I) -- Routing (I) -- Ad Hoc Networks (II) -- TCP (II) -- Routing (II) -- Ad Hoc Networks (III) -- Signal Processing -- Routing (III) -- Mobility -- Performance (I) -- Peer-to-Peer (I) -- Security (I) -- Performance (II) -- Peer-to-Peer (II) -- Security (II) -- Multicast (I) -- CDMA -- Security and Network Anomaly Detection -- Multicast (II) -- Networks -- Emergency, Disaster, Resiliency.The International Conference on Networking (ICN 2005) was the fourth conf- ence in its series aimed at stimulating technical exchange in the emerging and important ?eld of networking. On behalf of the International Advisory C- mittee, it is our great pleasure to welcome you to the proceedings of the 2005 event. Networking faces dramatic changes due to the customer-centric view, the venue of the next generation networks paradigm, the push from ubiquitous n- working,andthenewservicemodels.Despitelegacyproblems,whichresearchers and industry are still discovering and improving the state of the art, the ho- zon has revealed new challenges that some of the authors tackled through their submissions. InfactICN2005wasverywellperceivedbytheinternationalnetworkingc- munity. A total of 651 papers from more than 60 countries were submitted, from which 238 were accepted. Each paper was reviewed by several members of the Technical Program Committee. This year, the Advisory Committee revalidated various accepted papers after the reviews had been incorporated. We perceived a signi?cant improvement in the number of submissions and the quality of the submissions. TheICN2005programcoveredavarietyofresearchtopicsthatareofcurrent interest,startingwithGridnetworks,multicasting,TCPoptimizations,QoSand security, emergency services, and network resiliency. The Program Committee selected also three tutorials and invited speakers that addressed the latest - search results from the international industries and academia, and reports on ?ndings from mobile, satellite, and personal communications related to 3rd- and 4th-generation research projects and standardization.Computer Communication Networks and Telecommunications,2945-9184 ;3421Computer networksApplication softwareComputers and civilizationMultimedia systemsInformation storage and retrieval systemsTelecommunicationComputer Communication NetworksComputer and Information Systems ApplicationsComputers and SocietyMultimedia Information SystemsInformation Storage and RetrievalCommunications Engineering, NetworksComputer networks.Application software.Computers and civilization.Multimedia systems.Information storage and retrieval systems.Telecommunication.Computer Communication Networks.Computer and Information Systems Applications.Computers and Society.Multimedia Information Systems.Information Storage and Retrieval.Communications Engineering, Networks.004.6Lorenz Pascal1965-1437821Dini P(Petre)1752925MiAaPQMiAaPQMiAaPQBOOK9910484126403321Networking--ICN 20054188431UNINA