02863oam 2200517 450 991048368000332120210613104801.0981-336-232-410.1007/978-981-33-6232-1(CKB)5590000000430337(DE-He213)978-981-33-6232-1(MiAaPQ)EBC6449743(PPN)252512480(EXLCZ)99559000000043033720210613d2021 uy 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierMechanism of functional expression of f1-atpase /Masahiro Kinoshita1st ed. 2021.Singapore :Springer,[2021]©20211 online resource (XI, 79 p. 41 illus., 40 illus. in color.) SpringerBriefs in Molecular Science,2191-5407981-336-234-0 981-336-231-6 1. Introduction -- 2. A New View on Mechanism of Functional Expression of an ATP-Driven Motor -- 3. Mechanism of Unidirectional Rotation of γ-Subunit in F1-ATPase -- 4. Concluding Remarks.This book presents a new view of the mechanism of functional expression of ATP-driven motors (proteins or protein complexes). It is substantially different from the prevailing idea that the motor converts chemical energy to mechanical work. To facilitate understanding, the differences between the new and prevailing views are explained using many illustrations. The book is of interest to those who are not convinced of the notion of chemo–mechanical coupling. The claims presented are the following: The system, which comprises not only the motor but also water, does no mechanical work during the ATP hydrolysis cycle; a protein is moved or a protein in the complex is rotated by the entropic force generated by water. The highlight of the explanation in the book is that the mechanism of unidirectional rotation of the central shaft in F1-ATPase is discussed in detail on the basis of this new view. The hydration entropy of each β subunit to which a specific chemical compound (ATP, ADP and Pi, Pi, or nothing) is bound, the hydration entropy of the α3β3 complex, and the dependence of the hydration entropy of F1-ATPase on the orientation of the γ subunit play essential roles.SpringerBriefs in Molecular Science,2191-5407BiochemistryChemistryBiophysicsBiochemistry.Chemistry.Biophysics.572.793Kinoshita Masahiro1059440MiAaPQMiAaPQUtOrBLWBOOK9910483680003321Mechanism of functional expression of f1-atpase2848016UNINA