11177nam 2200529 450 99649986380331620230319142916.03-031-08881-6(MiAaPQ)EBC7133434(Au-PeEL)EBL7133434(CKB)25299348800041(PPN)266354556(EXLCZ)992529934880004120230319h20222005 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierVoltage-gated calcium channels /Gerald Werner Zamponi and Norbert Weiss, editorsCham, Switzerland :Springer,2022.©20051 online resource (705 pages)Print version: Zamponi, Gerald Werner Voltage-Gated Calcium Channels Cham : Springer International Publishing AG,c2022 9783031088803 Includes bibliographical references and index.Intro -- Preface -- Contents -- A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century -- Ca2+ as Central Ion for Muscle Contraction -- The "Ca-Spikes" of Crustacean Skeletal Muscles -- "Ca-Spikes" in Heart and Neurons -- How to Look at Ca2+ Currents Through Voltage-Clamp Recordings -- Ca2+ Currents in the Heart and Mollusc Neurons: The Problem of Blocking K+ Currents -- A Convergent View on the Existence of "a" Ca2+ Channel in Excitable Cells -- The "Patch-Clamp" Technique and the Explosive Interest on Ca2+ Channels -- The Discovery of the "Low-Voltage Activated" T-Type Channel -- The Unique Properties of T-Type (LVA) Channels -- The Explosive Interest on T-Type Channels -- The Ca2+ Channel Family Growths -- The N-Type Channel -- The P/Q-Type Channel -- The R-Type Channel -- From Ionic Currents to the Molecular Structure of Ca2+ Channels -- The cAMP-Mediated Enhancement of Cardiac L-Type Channels as First Example of Ca2+ Channel Modulation -- Early Observations on the GPCR-Mediated Inhibition of Neuronal Ca2+ Channels -- Towards a Full Understanding of the GPCR-Induced Delayed Activation of HVA Channels -- Looking Deeper to the Structure and Function of Cav2 Channels Modulation by G proteins -- Take-Home Message -- References -- Part I: Structural and Molecular Aspects of VGCCs -- Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels -- Introduction -- Purification and Biochemical Characterization of Skeletal Muscle Calcium Channels -- Structures of NaVAb and CaVAb Channels -- Structure of the Skeletal Muscle CaV1.1 Calcium Channel -- Molecular Properties of the CaV2 Family of Calcium Channels -- Structure of CaV2.2 Calcium Channels and Implications for Regulation -- Molecular Properties and Structure of CaV3 Calcium Channels -- Pharmacology of Calcium Channels -- Conclusion -- References.Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels -- Generation of mRNA Diversity by A-to-I RNA Editing and Alternative Splicing -- Splice Variations in High Voltage-Activated Calcium Channels -- CaV1.1 Splice Variant in Myotonic Dystrophy -- CaV1.2 Splice Variants in Health and Disease -- Exon 9* in Cardiovascular Diseases -- Mutually Exclusive Exons 1a/1 and Exons 8a/8 -- Exons 21/22 -- Exon 33 and Exon 33L -- CaV1.3 in Health and Disease -- The Pathophysiological Roles of CaV1.3 -- The Unique Biophysical and Pharmacological Properties of CaV1.3 Channels and Modulation -- Regulation of α1D Transcripts by Alternative Splicing and A-to-I RNA Editing -- CaV1.4 in Health and Disease -- Structure-Function Relationship Learnt from Human Mutations and Alternative Splicing Patterns -- The CaV2 Channel Family -- Pathophysiological Roles of CaV2 Channel Family -- Alternative Splicing in CaV2 Channel Family -- Exon 37 -- Exon 43/44 -- Exon 47 -- Novel Approaches to Uncover the Pathophysiological Consequences of Alternative Splicing or Gene Mutations of Ion Channels: Moving Away from Heterologous Systems -- Summary -- References -- Voltage-Gated Calcium Channel Auxiliary β Subunits -- Physiological Roles of High-Voltage-Activated Calcium Channels -- Subunits of Voltage-Gated Calcium Channels -- Physiological Roles of CaVβ Subunits -- Functional Effects of CaVβ Subunits in HVACC Complexes -- CaVβ Regulation of HVACC Membrane Trafficking -- CaVβ Regulation of HVACC Activation Gating -- CaVβ Regulation of HVACC Open Probability -- CaVβ Regulation of HVACC Inactivation Gating -- Structure-Function of CaVβ Regulation of HVACCs -- CaVβ-Interacting Proteins That Regulate HVACCs -- Regulation of HVACCs by RGK Proteins -- Roles of CaVβ and Rad in Sympathetic Regulation of Cardiac CaV1.2 -- RIM-Binding Protein Regulation of HVACCs.Association of CaVβ Subunits with Disease -- Pharmacological Targeting of CaVβ Subunits -- References -- Regulation of Calcium Channels and Synaptic Function by Auxiliary α2δ Subunits -- Introduction -- Discovery of α2δ Subunits -- Identification of α2δ Subunits -- Cloning -- Splice Variants -- Tissue Distribution of α2δ Subunits -- α2δ-1 -- α2δ-2 -- α2δ-3 -- α2δ-4 -- Structure of α2δ Subunits -- Biochemical and Bioinformatic Studies -- GPI Anchoring -- VWA Domain -- Cache Domains -- Proteolytic Maturation of α2δ -- Cachd1 Protein -- Molecular Structure of α2δ-1 -- Functions of α2δ Subunits as Calcium Channel Subunits -- Effects of Cloned α2δ Subunits on Calcium Currents -- Effects of α2δ Subunits on Biophysical Properties of Calcium Currents -- Effects of α2δ Subunits on Calcium Channel Trafficking -- Cachd1 Function -- Synaptic Functions of α2δ Proteins Beyond Their Role as Calcium Channel Subunits -- Importance of α2δ Proteins in Neuronal and Synaptic Functions -- Postsynaptic Functions of α2δ-1 -- Presynaptic and Trans-synaptic Roles of α2δ Proteins -- Diseases Associated with α2δ Subunits -- Ducky Mice and Human Mutations of the α2δ-2 Gene -- Mutations in the α2δ-1 Gene Associated with Cardiac Phenotypes -- Neuropathic Injury and the Role of α2δ-1 -- Disorders Associated with α2δ-3 -- Disorders Associated with α2δ-4 -- Psychiatric Disorders -- Pharmacology Involving α2δ Subunits -- Therapeutic Uses of Gabapentinoids -- Gabapentinoid Drug Binding to α2δ Subunits and Potential Mechanisms of Action -- The First Double Cache Domain in α2δ-1 Has Structural Homology to a Universal Amino Acid Binding Domain -- Effect of α2δ Subunits on Ziconotide Binding -- Other Interactions of α2δ Proteins -- Summary and Outlook -- References -- Voltage-Gated Calcium Channels in Invertebrates -- Introduction: Invertebrates and Calcium Channel Discovery.Phylogenetic Properties of the CaV Channel α1 Subunit -- Phylogenetic Properties of the CaV Channel β Subunit -- Phylogenetic Properties of the CaV Channel α2δ Subunit -- CaV Channels in Deuterostome Invertebrates -- Since Hagiwara's Discovery of LVA and HVA Ca2+ Currents in Starfish Eggs -- Tunicates and the Evolution of CaV1.1 Channels and Ryanodine Receptor Tetrad Coupling -- CaV Channels in Protostome Invertebrates -- The Atypical Nature of Calcium Channels in Parasitic Flatworms -- Functional Studies of Calcium Channels of the Pond Snail Lymnaea Stagnalis -- Genetic Studies of Ecdysozoan β and α2δ Subunits Highlight Gene Duplication as a Mechanism for Functional Diversification and the Emergence of Pleiotropic Functions -- Genetic and Functional Studies of Ecdysozoan CaV1-CaV3 Channels Reveal Deep Conservation of C-Terminal Protein Interactions and Sub-cellular Localization -- CaV Channels in Early-Diverging Animals -- Cnidaria: Our Most Distant Neural Ancestors? -- Evolutionary Insights from Functional Studies of the Placozoan CaV1 to CaV3 Channels -- A Calcium Channel Regulates Choanocyte Ciliary Beating and the Feeding Current in Sponges -- Ctenophores -- Conclusions -- References -- Untitled -- Part II: Regulation of VGCCs -- Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers -- Introduction -- Modulation of Cav1 Channels by GPCRs and Second Messengers -- β-Adrenergic Modulation of L-Type Channels: Activation of the Gs Signaling Pathway -- Gq-Coupled GPCR Modulation of L-Type Channels -- Gi/o-Coupled GPCR Modulation of L-Type Channels -- GPCR-Mediated Modulation of Cav1.4 in the Retina -- Modulation of Cav2 Channels by GPCRs and Second Messengers -- Mechanisms Gi/o Mediated Inhibition: Fast, Direct, Voltage-Dependent -- Cav2 Channel Interaction Sites with Gβγ Subunits.Gβγ and Cavβ Subunit Diversity and Interaction Sites with Cav2 Channels -- Modulation of G Protein-Mediated Inhibition by Synaptic Associated and Other Proteins -- Regulation of Cav2 Channels by Lipids -- Mechanisms of Gq/11-Mediated Inhibition: Slow, Indirect, Voltage-Independent -- Conclusion for Cav2 Channels -- Modulation of Cav3 Channels by GPCRs and Second Messengers -- Direct Modulation by Gβγ Subunits -- Modulation by Kinases -- Protein Kinase A -- Protein Kinase C -- Calmodulin-Dependent Kinase II -- Protein Kinase G -- Rho-Kinase -- Tyrosine Kinase -- GPCR-Mediated Change in T-Type Channel Expression -- Conclusion for T-Type Channels -- Summary -- References -- Trafficking of Neuronal Calcium Channels -- Introduction -- Regulation of VGCCs by Ancillary Subunits -- Cavβ-Subunit -- Cavα2δ-Subunit -- Cavγ-Subunit -- Regulation of VGCCs by Other Interacting Proteins -- Calmodulin -- Collapsin Response Mediator Proteins -- Stac Adaptor Proteins -- Kelch-like 1 -- Calnexin -- Secretory Carrier-Associated Membrane Proteins -- Receptor for Activated C kinase 1 -- Regulation of VGCCs by Posttranslational Modifications -- Ubiquitination -- Glycosylation -- Subcellular Targeting of VGCCs -- Concluding Remarks and Perspectives -- References -- Calmodulin Regulation of Voltage-Gated Calcium Channels -- Introduction -- Ca2+/CaM-Dependent Regulation of VGCCs -- Ca2+/CaM-Dependent Regulation Responds Differentially to Spatially Distinct Ca2+ Sources -- Molecular Mechanism of Calmodulation -- Ca2+ Regulation of VGCCs in Disease -- References -- Cav3 Calcium Channel Interactions with Potassium Channels -- Introduction -- Cav3-Kv4 Complex -- Cav3.2-IK Complex -- Cav3.2-BK Complex -- Perspectives and Conclusions -- References -- Part III: (Patho)physiology of VGCCs -- Voltage-Gated Ca2+ Channels. Lessons from Knockout and Knock-in Mice -- Introduction -- CaV1.CaV1.1.Calcium channelsRNA editingNeurosciencesCalcium channels.RNA editing.Neurosciences.572.516Zamponi Gerald W.Weiss NorbertMiAaPQMiAaPQMiAaPQBOOK996499863803316Voltage-gated calcium channels3064947UNISA09975nam 22008055 450 991048361980332120251226193434.03-319-07230-710.1007/978-3-319-07230-2(CKB)3710000000143827(SSID)ssj0001276041(PQKBManifestationID)11841588(PQKBTitleCode)TC0001276041(PQKBWorkID)11239074(PQKB)11504588(DE-He213)978-3-319-07230-2(MiAaPQ)EBC3093149(PPN)179766007(EXLCZ)99371000000014382720140607d2014 u| 0engurnn#008mamaatxtccrHuman-Computer Interaction. Advanced Interaction, Modalities, and Techniques 16th International Conference, HCI International 2014, Heraklion, Crete, Greece, June 22-27, 2014, Proceedings, Part II /edited by Masaaki Kurosu1st ed. 2014.Cham :Springer International Publishing :Imprint: Springer,2014.1 online resource (XXVI, 805 p. 355 illus.)Information Systems and Applications, incl. Internet/Web, and HCI,2946-1642 ;8511Bibliographic Level Mode of Issuance: Monograph3-319-07229-3 Gesture-Based Interaction -- RemoteHand: A Wireless Myoelectric Interface -- Early Prototyping of 3D-Gesture Interaction within the Presentation- Gesture-Dialog Design Space -- The Study of the Full Cycle of Gesture Interaction, The Continuum between 2D and 3D -- iPanel: A Computer-Vision Based Solution for Interactive Keyboard and Mouse -- Adding Multi-Touch Gesture Interaction in Mobile Web Applications -- Harmonic Navigator: An Innovative, Gesture-Driven User Interface for Exploring Harmonic Spaces in Musical Corpora -- HandyScope: A Remote Control Technique Using Circular Widget on Tabletops -- Comparing Hand Gesture Vocabularies for HCI -- Effectiveness of Virtual Hands in 3D Learning Material -- Proposal of the Effective Method of Generating Characteristic Gestures in Nonverbal Communication -- Hand-Object Interaction: From Grasping to Using -- Model-Based Multi-touch Gesture Interaction for Diagram Editors -- Multi-sensor Finger Ring for Authentication Based on 3D Signatures -- What You DrawIs What You Search: The Analog Gesture -- Remote Collaboration with Spatial AR Support -- Prediction of Multi-touch Gestures during Input -- “Will Use It, Because I Want to Look Cool” A Comparative Study of Simple Computer Interactions Using Touchscreen and In-Air Hand Gestures -- Beyond Presentation - Employing Proactive Intelligent Agents as Social Catalysts -- A Method for Lifelong Gesture Learning Based on Growing Neural Gas -- Gesture, Gaze and Activity Recognition -- The Issues of 3D Hand Gesture and Posture Recognition Using the Kinect -- Frontal-Standing Pose Based Person Identification Using Kinect -- A Virtual Handwriting Tablet Based on Pen Shadow Cues -- HOUDINI: Introducing Object Tracking and Pen Recognition for LLP Tabletops -- Detecting Address Estimation Errors from Users’ Reactions in Multi-user Agent Conversation -- Evaluation of Leap Motion Controller with a High Precision Optical Tracking System -- Proposal of a Method to Measure Difficulty Level of Programming Code with Eye-Tracking -- Expressing Observation Direction through Face and Body Rotation in a Multi-user Conversation Setting -- Gaze Location Prediction with Depth Features as Auxiliary Information -- Study and Evaluation of Separability Techniques and Occlusion in Multitouch Surfaces -- Human Activity Recognition from Kinect Captured Data Using Stick Model -- Multi-sensor Based Gestures Recognition with a Smart Finger Ring -- View-Invariant Human Detection from RGB-D Data of Kinect Using Continuous Hidden Markov Model -- A Survey of Datasets for Human Gesture Recognition -- Speech, Natural Language and Conversational Interfaces -- Accessing Cause-Result Relation and Diplomatic Information in Ancient “Journalistic” Texts with Universal Words -- Human Factors in the Design of Arabic-Language Interfaces in Assistive Technologies for Learning Difficulties -- Design and Development of Speech Interaction: A Methodology -- Introducing Consciousnet: Internet Content as an Environment for Human-Machine Interaction -- Can User-Paced, Menu-free Spoken Language Interfaces Improve Dual Task Handling While Driving? -- Chinese Romanization and Its Application in HCI -- Driving with a Speech Interaction System: Effect of Personality on Performance and Attitude of Driver -- Effects of Language Variety on Personality Perception in Embodied Conversational Agents -- Long Text Reading in a Car -- Let’s Get Personal: Assessing the Impact of Personal Information in Human-Agent Conversations -- Multimodal Behaviours in Comparable Danish and Polish Human-Human Triadic Spontaneous Interactions -- Building Rapport between Human and ECA: A Pilot Study -- The Effect of Voice Instruction on the Construction of Mental Model -- Discourse Particles and User Characteristics in Naturalistic Human-Computer Interaction -- The Effects of Working Memory Load and Mental Imagery on Metaphoric Meaning Access in Metaphor Comprehension -- Natural and Multimodal Interfaces -- Human Factors in the Design of BCI-Controlled Wheelchairs -- Interface Design and Dynamic Audio -- A Pictorial Interaction Language for Children to Communicate with Cultural Virtual Characters -- Tangible or Not Tangible – A Comparative Study of Interaction Types for Process Modeling Support -- Body Image and Body Schema: Interaction Design for and through Embodied Cognition -- Exploring Initiative Interactions on a Proxemic and Ambient Public Screen -- Evaluation of Tactile Drift Displays in Helicopter -- Development of Interaction Concepts for Touchless Human-Computer Interaction with Geographic Information Systems -- Spyractable: A Tangible User Interface Modular Synthesizer -- Neural Interface Emotiv EPOC and Arduino: Brain-Computer Interaction in a Proof of Concept -- A Heuristic Model of Vibrotactile Haptic Feedbacks Elicitation Based on Empirical Review -- Auditory Emoticons: Iterative Design and Acoustic Characteristics of Emotional Auditory Icons and Earcons -- Natural Forms of Communication and Adaptive Behaviour in Human-Computer-Interaction -- Human-Robot Interaction -- Backchannel Head Nods in Danish First Meeting Encounters with a Humanoid Robot: The Role of Physical Embodiment -- Recommended Considerations for Human-Robot Interaction Communication Requirements -- An Emotional Framework for a Real-Life Worker Simulation: Emotional Valence Scoring Inside a Workflow Enhancement Simulator -- Behavioral Persona for Human-Robot Interaction: A Study Based on Pet Robot -- Robotic Border Crosser TNG - Creating an Interactive Mixed Reality -- Emotion Transmission System Using a Cellular Phone-Type Teleoperated Robot with a Mobile Projector -- Emotions Recognition -- Design of an Emotion Elicitation Framework for Arabic Speakers -- Analysing Emotional Video Using Consumer EEG Hardware -- Emotracking Digital Art -- Estimation of Emotion by Electroencephalography for Music Therapy -- Evaluating User’s Emotional Experience in HCI: The PhysiOBS Approach -- Proposal for the Model of Occurrence of Negative Response toward Humanlike Agent Based on Brain Function byQualitative Reasoning -- Current and New Research Perspectives on Dynamic Facial Emotion Detection in Emotional Interface -- Evaluation of Graceful Movement in Virtual Fitting through Expressed Emotional Response and Emotion Expressed via Physiology Measures.The 3-volume set LNCS 8510, 8511 and 8512 constitutes the refereed proceedings of the 16th International Conference on Human-Computer Interaction, HCII 2014, held in Heraklion, Crete, Greece in June 2014. The total of 1476 papers and 220 posters  presented at the HCII 2014 conferences was carefully reviewed and selected from 4766 submissions. These papers address the latest research and development efforts and highlight the human aspects of design and use of computing systems. The papers thoroughly cover the entire field of human-computer interaction, addressing major advances in knowledge and effective use of computers in a variety of application areas.Information Systems and Applications, incl. Internet/Web, and HCI,2946-1642 ;8511User interfaces (Computer systems)Human-computer interactionEducationData processingInteractive multimediaMultimedia systemsArtificial intelligenceInformation storage and retrieval systemsComputer scienceUser Interfaces and Human Computer InteractionComputers and EducationMedia DesignArtificial IntelligenceInformation Storage and RetrievalComputer ScienceUser interfaces (Computer systems)Human-computer interaction.EducationData processing.Interactive multimedia.Multimedia systems.Artificial intelligence.Information storage and retrieval systems.Computer science.User Interfaces and Human Computer Interaction.Computers and Education.Media Design.Artificial Intelligence.Information Storage and Retrieval.Computer Science.005.4374.019Kurosu Masaakiedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910483619803321Human-Computer Interaction. Advanced Interaction, Modalities, and Techniques2587610UNINA