03985oam 2200721I 450 991045783580332120200520144314.00-429-15227-21-280-12193-997866135257961-4398-3633-710.1201/b11523 (CKB)2550000000087901(EBL)863087(OCoLC)778448453(SSID)ssj0000598641(PQKBManifestationID)11369726(PQKBTitleCode)TC0000598641(PQKBWorkID)10610159(PQKB)10300161(MiAaPQ)EBC863087(Au-PeEL)EBL863087(CaPaEBR)ebr10531164(CaONFJC)MIL352579(OCoLC)785779620(EXLCZ)99255000000008790120180331d2012 uy 0engur|n|---|||||txtccrBiodefense research methodology and animal models /edited by James R. Swearengen2nd ed.Boca Raton :CRC Press,2012.1 online resource (415 p.)Description based upon print version of record.1-4398-3632-9 Includes bibliographical references.History of biological agents as weapons / James W. Martin -- Bioterrorism and biowarfare : similarities and differences / Nelson W. Rebert -- Scientific and ethical importance of animal models in biodefense research / James R. Swearengen and Arthur O. Anderson -- Development and validation of animal models / Jaime B. Anderson and Kenneth Tucker -- Infectious disease aerobiology : aerosol challenge methods / Chad J. Roy and Louise M. Pitt -- Characterization of new and advancement of existing animal models of bacillus anthracis infection / Elizabeth K. Leffel and Louise M. Pitt -- Glanders / David L. Fritz and David M. Waag -- Plague / Jeffery J. Adamovicz and Patricia L. Worsham -- Tularemia / Jeffery J. Adamovicz and David M. Waag -- Q fever / David M. Waag and David L. Fritz -- Brucellosis / Bret K. Purcell and Robert Rivard -- Alphaviruses / William D. Pratt ... [et al.] -- Orthopoxviruses / Peter B. Jahrling and Victoria Wahl-Jensen -- Animal models for viral hemorrhagic fevers / Kelly l. Warfield and Thomas W. Geisbert -- Botulinum toxins / Stephen B. Greenbaum, Jaime B. Anderson, and Frank J. Lebeda -- Ricin / Stephen B. Greenbaum and Jaime B. Anderson -- Staphylococcal and streptococcal superantigens : in vitro and in vivo assays / Teresa Krakauer and Bradley G. Stiles.Significant advances have been made in animal model development for biological research since the publication of the first edition of this volume, and the ramifications of the FDA's Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated with the latest research findings, Biodefense Research Methodology and Animal Models, Second Edition spans the spectrum of coverage from basic research to advanced development of medical countermeasures.Topics discussed in this volume include:A historyBioterrorismPreventionResearchInfectionAnimal modelsCommunicable diseasesResearchBiological weaponsAlternative toxicity testingToxinsResearchElectronic books.BioterrorismPreventionResearch.InfectionAnimal models.Communicable diseasesResearch.Biological weapons.Alternative toxicity testing.ToxinsResearch.363.325/3Swearengen James R987209MiAaPQMiAaPQMiAaPQBOOK9910457835803321Biodefense research methodology and animal models2256343UNINA03263oam 2200517 450 991048331430332120210416123857.03-030-54391-910.1007/978-3-030-54391-4(CKB)4100000011513458(DE-He213)978-3-030-54391-4(MiAaPQ)EBC6381389(PPN)269151346(EXLCZ)99410000001151345820210416d2021 uy 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierThe spectrum of neuroendocrine neoplasia a practical approach to diagnosis, classification and therapy /edited by Sylvia L. Asa, Stefano La Rosa, Ozgur1st ed. 2021.Cham, Switzerland :Springer,[2021]©20211 online resource (XI, 478 p.) Includes index.3-030-54390-0 Historical Background and Terminologies -- Clinical, Radiological and Biochemical Diagnosis of NENs -- Pituitary NENs -- NENs of the upper respiratory tract -- Thyroid NENs -- Parathyroid NENs -- Thoracic NENs (Lung/thymus) -- NENs of the tubular gut -- Pancreatic NENs -- Paragangliomas and tumors of the Adrenal Medulla -- Breast NENs -- Genitourinary NENs -- Skin NENs -- Metastatic NENs of unknown primary -- Cytology of NENs: Bongiovanni, Schmitt (Bern) -- Inherited NEN syndromes -- Management of the NEN patient.Neuroendocrine neoplasms comprise a large family of proliferative lesions that involve almost every part of the body. Our understanding of their cells of origin as well as the pathology, pathophysiology and genetics of these neoplasms has made tremendous advances in the last few decades. While they are often discussed as separate entities in textbooks of gastroenteropancreatic pathology and pulmonary pathology, their scope is much broader. The book conveys the similarities and differences of these fascinating tumors that may be found from the hypothalamus and pituitary to the rectum, and in soft tissue as well as in many organs. Written by experts in the field, the authors emphasize their structural, functional, predictive and prognostic features and attempt to provide the clinical context that allows improved diagnosis and therapy while building on the genetics that clarifies patterns of inheritance and predisposition to tumor development through precursor lesions. The Spectrum of Neuroendocrine Neoplasia provides a broad overview of neuroendocrine neoplasms using a practical approach to diagnosis, histological classification and therapy, and presents the most important and significant developments of the technologies used to diagnose, classify and treat them.EndocrinologyOncologyPathologyEndocrinology.Oncology.Pathology.016.6151La Rosa StefanoAsa Sylvia L.Mete OzgurMiAaPQMiAaPQUtOrBLWBOOK9910483314303321The spectrum of neuroendocrine neoplasia2571676UNINA