01541nam 2200265la 450 991048274490332120221108044135.0(UK-CbPIL)2090322877(CKB)5500000000093725(EXLCZ)99550000000009372520210618d1561 uy |laturcn||||a|bb|Refutatio calumniarum cuiusdam Joannis Magni Gothi Upsalensis, quibus in historia sua ac famosa oratione, Danicam gentem incessit, ad serenissimum illustrissimumq[ue] principem ac dominum D. Fridericum eius nominis 2. Danorum, Norvagicorum ... regem ... scripta a Ioanne Svaningio, huic accessit Chronicon sive Historia Ioannis Regis Daniæ ..., recens collecta atque ædita[electronic resource]Copenhagen Christophorum Barth1561Online resource ([12] bl.)Reproduction of original in Det Kongelige Bibliotek / The Royal Library (Copenhagen).Svaning Hans1503-1584.871101Svaning Hans1503-1584.871101Uk-CbPILUk-CbPILBOOK9910482744903321Refutatio calumniarum cuiusdam Joannis Magni Gothi Upsalensis, quibus in historia sua ac famosa oratione, Danicam gentem incessit, ad serenissimum illustrissimumq principem ac dominum D. Fridericum eius nominis 2. Danorum, Norvagicorum ... regem ... scripta a Ioanne Svaningio, huic accessit Chronicon sive Historia Ioannis Regis Daniæ ..., recens collecta atque ædita1944578UNINA01081nam 2200373 450 991015427400332120230213222754.01-4574-8486-2(CKB)3710000000919987(MiAaPQ)EBC4727501(EXLCZ)99371000000091998720161118h19851985 uy 0engurcnu||||||||rdacontentrdamediardacarrierJephthaMiniature vocal score an orotario, with English text /George Frideric Handel[Los Angeles, California] :Kalmus,[1985]©[1985]1 online resource (206 pages) illustrationsKalmus classic edition ;K 06873Includes index.0-7692-4554-4 Kalmus classic edition ;K 06873.222.32092Handel George Frideric158944MiAaPQMiAaPQMiAaPQBOOK9910154274003321Jephtha3006179UNINA05371nam 2200469z- 450 991034675230332120210211(CKB)4920000000094191(oapen)https://directory.doabooks.org/handle/20.500.12854/49518(oapen)doab49518(EXLCZ)99492000000009419120202102d2018 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierHomeostasis and Allostasis of Thyroid FunctionFrontiers Media SA20181 online resource (107 p.)Frontiers Research Topics2-88945-570-X The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite "normal" TSH values.</p><p>A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. </p><p>Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome.</p><p>A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment.</p><p>Considerable progress has been made in this respect in the following key areas:</p><p>• the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure,</p><p>• the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects,</p><p>• the emergence of "non-canonical" mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression,</p><p>• the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates,</p><p>• the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load.</p><p>This collective volume contains the contributions to the Research Topic "Homeostasis and Allostasis of Thyroid Function", which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.Medicine and Nursingbicssc3-T1AMHypothyroidismHysteresisprecision medicinerelational stabilityStratified Medicinethyroid allostasisThyroid homeostasisThyronaminesTSH-T3 ShuntMedicine and NursingRudolf Hoermannauth1325061John E. M. MidgleyauthJohannes W. DietrichauthBOOK9910346752303321Homeostasis and Allostasis of Thyroid Function3036530UNINA