02082nam 2200505 450 991047890260332120200929115046.00-271-07790-50-271-07792-1(CKB)3710000001055883(OCoLC)1080551191(MdBmJHUP)muse68681(MiAaPQ)EBC6224760(EXLCZ)99371000000105588320200929d2016 uy 0engur|||||||nn|ntxtrdacontentcrdamediacrrdacarrierThe continuity of the conquest Charlemagne and Anglo-Norman imperialism /Wendy Marie HoofnagleUniversity Park, Pennsylvania :The Pennsylvania State University Press,[2016]©20161 online resource (viii, 193 pages )0-271-07401-9 Includes bibliographical references (pages 165-188) and index.Conversion politics and the ideology of imperialism -- Making their mark : the imperial ideology of topography -- Taming the wild beast : a new look at the new forest."An interdisciplinary study examining the origins of Anglo-Norman views of kingship in idealized interpretations of Charlemagne's imperium. Demonstrates how the idea of "Englishness" developed in the Middle Ages as much as a consequence of the Anglo-Norman imagination and experience as a reaction against it"--Provided by publisher.ImperialismNormansEnglandHistoryTo 1500Great BritainHistoryNorman period, 1066-1154EnglandCivilization1066-1485Great BritainPolitics and government1066-1154Electronic books.Imperialism.NormansHistory942.02Hoofnagle Wendy Marie995245MiAaPQMiAaPQMiAaPQBOOK9910478902603321The continuity of the conquest2279994UNINA01717ojm 2200229z- 450 991015568580332120230913112557.01-62188-649-2(CKB)3710000000976679(BIP)057496839(EXLCZ)99371000000097667920231107c2017uuuu -u- -engPurgatory RoadOasis AudioNamed one of Library Journal's Best Books of 2017"Exceptional first novel."--Publishers Weekly, starred review"Will grip suspense aficionados from the first page."--Library Journal, starred review"A skillfully written, gripping thriller."--Booklist"Action-packed with breakneck pacing."--Foreword ReviewsWhen a day trip out of Las Vegas with his wife takes a turn for the worse, Jack is sure that he has the ability to get them home. But he drove into something far beyond reason.Rescue comes in the form of a desert hermit, but hope fades as the couple comes to realize that the nomad has no intention of letting them leave. A chance encounter with a kidnapped runaway and her crazed abductor leads them all farther into the wilderness--and closer to the cold brutality that isolation brings.At the edge of his sanity, Jack begins to learn that playing by another's rules may be the only way to survive.In a voice that is as hypnotizing as a desert mirage, debut novelist Samuel Parker entices readers down a dangerous road, where the forces of good and evil are as crushing as the Mojave heat. This is suspense in its purest, most unfiltered form.Parker Samuel820420Gallagher DeannrtAUDIO9910155685803321Purgatory Road3599511UNINA03287nam 2200433 450 991080905970332120230808204630.03-8325-8802-7(CKB)4100000010135043(MiAaPQ)EBC60328485e469732-80fc-4a5f-b54c-4e00b0dd2d03(EXLCZ)99410000001013504320200317d2016 uy 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierThe role of microRNAs in controlling protein expression noise /von Diplom Biophysiker Jörn Matthias SchmiedelBerlin :Logos Verlag Berlin,[2016]©20161 online resource (116 pages) illustrationsPublicationDate: 201603313-8325-4216-7 Includes bibliographical references (pages 103-114).Long description: The expression of genes is based on stochastic processes, which lead to temporal fluctuations in the number of proteins of each gene. If such fluctuations become too large they can be detrimental to the fitness of an organisms, because most cellular processes are based on the precise interaction of proteins. This PhD thesis explores the role of post-transcriptional regulatory mechanisms in the control of stochasticity in gene expression, with a focus on microRNAs, common regulators in multicellular organisms. Bioinformatic data analysis, mathematical modeling and single cell expression experiments are used to analyze the conditions under which microRNAs can lead to the reduction of fluctuations in gene expression. The central insight of this thesis is that microRNAs can indeed reduce fluctuations for most genes and that they are likely used by organisms for this purpose, thus ensuring precision to gene expression during development and the maintenance of the adult body. Der Expression von Genen liegen stochastische Prozesse zu Grunde, die zu Fluktuationen in der Menge von Proteinen eines jeden Gens führen. Zu starke Fluktuationen in Proteinmengen können für Organismen schädlich sein, da die meisten zellulären Prozesse auf der präzisen Wechselwirkung von Proteinen beruhen. Diese Dissertationsschrift befasst sich mit dem Einfluss von post-transkriptionellen Regulationsmechanismen auf die stochastischen Prozesse der Genexpression. Mittels bioinformatischer Datenanalyse, mathematischer Modellierung und gezielten Einzelzellexperimenten wird mit Fokus auf die in Mehrzellern weitverbreiteten microRNAs erforscht unter welchen Voraussetzungen Organismen post-transkriptionelle Regulation zu Verringerung von Fluktuationen benutzen können. Die zentrale Erkenntnis der vorliegenden Arbeit ist, dass microRNAs für die meisten Gene Fluktuationen verringern können und auch zu diesem Zweck genutzt werden.Gene expressionMicroRNAGene expression.MicroRNA.572.865Schmiedel Jörn Matthias1985-1719110MiAaPQMiAaPQMiAaPQBOOK9910809059703321The role of microRNAs in controlling protein expression noise4116637UNINA03474nam 2200841 a 450 991082393170332120240313165119.09781118329399111832939297811185559271118555929978111855599611185559969781299277588129927758697811185559651118555961(CKB)2560000000099429(EBL)1138989(OCoLC)830163323(OCoLC)829706585(MiAaPQ)EBC1138989(MiAaPQ)EBC4433802(Au-PeEL)EBL1138989(CaPaEBR)ebr10671577(Perlego)1000261(Perlego)2785805(EXLCZ)99256000000009942920130116d2013 uy 0engurcn|||||||||rdacontentrdamediardacarrierThe transhumanist reader classical and contemporary essays on the science, technology, and philosophy of the human future /edited by Max More and Natasha Vita-More1st ed.Chichester, West Sussex, U.K. Wiley-Blackwell2013460 pagesIncludes index.9781118334294 1118334299 9781118334317 1118334310 Includes bibliographical references and index.pt. I. Roots and core themes -- pt. II. Human enhancement : the somatic sphere -- pt. III. Human enhancement : the cognitive sphere -- pt. IV. Core technologies -- pt. V. Engines of life : identity and beyond death -- pt. VI. Enhanced decision-making -- pt. VII. Biopolitics and policy -- pt. VIII. Future trajectories : singularity -- pt. IX. The world's most dangerous idea.The first authoritative and comprehensive survey of the origins and current state of transhumanist thinking The rapid pace of emerging technologies is playing an increasingly important role in overcoming fundamental human limitations. Featuring core writings by seminal thinkers in the speculative possibilities of the posthuman condition, essays address key philosophical arguments for and against human enhancement, explore the inevitability of life extension, and consider possible solutions to the growing issues of social and ethical implications and concerns. Edited by the internationalMedical technologySocial aspectsHumanismHistoryHuman body (Philosophy)HistoryGenetic engineeringSocial aspectsTecnologia mèdicathubCondicions socialsthubHumanismethubEnginyeria genèticathubLlibres electrònicsthubMedical technologySocial aspects.HumanismHistory.Human body (Philosophy)History.Genetic engineeringSocial aspects.Tecnologia mèdicaCondicions socialsHumanismeEnginyeria genètica.610.285More Max1964-1720061Vita-More Natasha1950-1720062MiAaPQMiAaPQMiAaPQBOOK9910823931703321The transhumanist reader4118396UNINA