05145nam 2200697 a 450 991046468880332120200520144314.01-283-62774-43-11-025877-3978661394019310.1515/9783110258776(CKB)3360000000446089(EBL)893470(SSID)ssj0000720578(PQKBManifestationID)12314900(PQKBTitleCode)TC0000720578(PQKBWorkID)10669443(PQKB)11367686(MiAaPQ)EBC893470(DE-B1597)124093(OCoLC)1046616346(OCoLC)1047015769(OCoLC)1049633945(OCoLC)1054881669(OCoLC)775848015(OCoLC)817558102(DE-B1597)9783110258776(Au-PeEL)EBL893470(CaPaEBR)ebr10606388(CaONFJC)MIL394019(EXLCZ)99336000000044608920120509d2012 uy 0engur|n|---|||||txtccrExtracellular matrix[electronic resource] pathobiology and signaling /edited by Nikos K. KaramanosBerlin Walter de Gruyterc20121 online resource (940 p.)Description based upon print version of record.3-11-025876-5 Includes bibliographical references and index.An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis ... [et al.] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos.Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting.It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, SwedenOver the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting.Extracellular matrixCellular signal transductionElectronic books.Extracellular matrix.Cellular signal transduction.611/.0182WE 3900rvkKaramanos Nikos K1041536MiAaPQMiAaPQMiAaPQBOOK9910464688803321Extracellular matrix2465128UNINA01532nam 2200385Ka 450 991069585180332120070531151158.0(CKB)5470000002373273(OCoLC)137288504(EXLCZ)99547000000237327320070531d2007 ua 0engtxtrdacontentcrdamediacrrdacarrierThe photoload sampling technique[electronic resource] estimating surface fuel loadings from downward-looking photographs of synthetic fuelbeds /Robert E. Keane and Laura J. Dickinson[Fort Collins, CO] :U.S. Dept. of Agriculture, Forest Service, Rocky Mountain Research Station,[2007]44 pages digital, PDF fileGeneral technical report RMRS ;GTR-190Title from title screen (viewed on May 31, 2007)."April 2007."Photoload sampling technique FuelwoodSamplingTechnological innovationsForest ecologyObservationsTechnological innovationsFuelwoodSamplingTechnological innovations.Forest ecologyObservationsTechnological innovations.Keane Robert E1058744Dickinson Laura J1405099Rocky Mountain Research Station (Fort Collins, Colo.)GPOGPOBOOK9910695851803321The photoload sampling technique3500148UNINA